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| Article | Gene | RS ID | Risk Allele | Your Genotype | Notes About Risk Allele |
|---|---|---|---|---|---|
| MTHFR | MTHFR C677T | rs1801133 | A | — | 40-70% decrease in MTHFR enzyme function (folate metabolism) |
| MTHFR | MTHFR A1298C | rs1801131 | G | — | 10-20% decrease in MTHFR enzyme function (folate metabolism) |
| Vitamin B12 | MTRR | rs1801394 | G | — | Decreased MTRR, affects B12 |
| Vitamin B12 | FUT2 | rs601338 | A | — | AA only: non-secretor, serum B12 tests may be inaccurate |
| Vitamin B12 | TCN1 | rs526934 | G | — | B12 transporter, lower circulating B12 |
| Vitamin B12 | TCN2 | rs9606756 | G | — | B12 binding protein, reduced B12 levels |
| Riboflavin | MTHFR | rs1801133 | A | — | Riboflavin may help lower homocysteine |
| Riboflavin | FMO3 | rs1736557 | A | — | Decreased FMO3; riboflavin may help |
| Riboflavin | FMO3 | rs28363581 | C | — | Decreased FMO3; riboflavin may help |
| Riboflavin | FMO3 | rs3832024 | D | — | Decreased FMO3; riboflavin may help |
| Riboflavin | FMO3 | rs2266782 | A | — | Decreased FMO3; riboflavin may help |
| Riboflavin | FMO3 | rs909530 | T | — | Decreased FMO3; riboflavin may help |
| Riboflavin | FMO3 | rs2266780 | G | — | Decreased FMO3; riboflavin may help |
| Riboflavin | FMO3 | rs61753344 | T | — | Decreased FMO3; riboflavin may help |
| Riboflavin | FMO3 | rs909530 | T | — | Decreased FMO3; riboflavin may help |
| Riboflavin | ETFDH | i5007876 | A | — | Multiple ACAD (rare) |
| Riboflavin | SLC52A3 | i5008314 | A | — | Brown-Vialetto-Van Laere (rare) |
| Riboflavin | SLC25A32 | rs147014855 | T | — | Exercise intolerance that responds to riboflavin |
| Vitamin B6 | ALPL | rs1256335 | G | — | Decreased vitamin B6 |
| Vitamin B6 | ALPL | rs1697421 | T | — | Slightly decreased vitamin B6 levels |
| Vitamin B6 | ALPL | rs1780316 | T | — | Slightly decreased vitamin B6 levels |
| Vitamin B6 | ALPL | rs4654748 | C | — | Slightly decreased vitamin B6 levels |
| Vitamin B6 | ALDH7A1 | rs121912707 | G | — | Mutation linked to vitamin B6 dependent epilepsy (rare) |
| Vitamin B6 | ALDH7A1 | rs121912708 | A | — | rare mutation linked to vitamin B6 dependent epilepsy |
| Vitamin C | SLC23A1 | rs6133175 | G | — | Higher plasma vitamin C levels |
| Vitamin C | SLC23A1 | rs12479919 | T | — | Higher plasma vitamin C levels |
| Vitamin C | SLC23A1 | rs6053005 | T | — | Higher plasma vitamin C levels |
| Vitamin C | SLC23A1 | rs33972313 | T | — | Lower plasma vit. C |
| Vitamin C | SLC23A1 | rs10063949 | C | — | Lower plasma vit. C |
| Vitamin C | SLC23A1 | rs33972313 | T | — | Lower plasma vit. C |
| Biotin (B7) | BTD | rs13078881 | C | — | Reduced enzyme activity |
| Biotin (B7) | BTD | rs28934601 | G | — | Mutation related to biotin deficiency (rare) |
| Biotin (B7) | BTD | rs13073139 | A | — | Mutation related to biotin deficiency (rare) |
| Biotin (B7) | BTD | rs80338684 | T | — | Mutation related to biotin deficiency (rare) |
| Biotin (B7) | BTD | rs34885143 | A | — | Mutation related to biotin deficiency (rare) |
| Zinc | IL-6 | rs1800795 | G | — | Zinc modulates inflammation |
| Zinc | SLC30A8 | rs13266634 | T | — | Zinc may decrease blood glucose (if high) |
| Zinc | SLC30A8 | rs11558471 | A | — | Zinc may decrease blood glucose (if high) |
| Zinc | SLC30A2 | rs587776926 | C | — | Zinc transporter deficiency |
| Zinc | SLC30A2 | rs185398527 | T | — | Zinc transporter deficiency |
| Zinc | SLC30A2 | rs117153535 | A | — | Zinc transporter deficiency |
| Zinc | SLC39A2 | rs2234632 | T | — | Zinc reduces inflammation |
| Zinc | SLC39A13 | rs121434363 | A | — | Mutation linked to Ehlers-Danlos, zinc dependent |
| Zinc | CA1 | rs1532423 | A | — | AA: higher serum zinc |
| Thiamine (B1) | SLC19A2 | rs2038024 | C | — | Increased risk of venous thromboembolism |
| Thiamine (B1) | SLC19A2 | rs28937595 | A | — | Mutation linked to thiamine-responsive megoblastic anemia (rare) |
| Thiamine (B1) | SLC19A2 | rs121908540 | A | — | Mutation linked to thiamine-responsive megoblastic anemia (rare) |
| Thiamine (B1) | SLC19A2 | rs74315373 | A | — | Mutation linked to thiamine-responsive megoblastic anemia (rare) |
| Thiamine (B1) | SLC19A2 | rs74315374 | T | — | Mutation linked to thiamine-responsive megoblastic anemia (rare) |
| Thiamine (B1) | SLC19A2 | rs74315375 | T | — | Mutation linked to thiamine-responsive megoblastic anemia (rare) |
| Thiamine (B1) | SLC19A3 | rs121917884 | C | — | Mutation related to basal ganglia disease (rare) |
| Thiamine (B1) | SLC19A3 | rs121917882 | A | — | Mutation related to basal ganglia disease (rare) |
| Thiamine (B1) | SLC22A1 | rs72552763 | D | — | reduced thiamine transport |
| Thiamine (B1) | TPK1 | rs371271054 | C | — | Carrier of thiamine-related mutation |
| Thiamine (B1) | SLC25A19 | rs119473030 | G | — | Mutation for microcephaly |
| Thiamine (B1) | PHDC | rs28933391 | A | — | AA = pathogenic for Pyruvate dehydrogenase deficiency (Important) |
| Thiamine (B1) | PHDC | rs28935769 | C | — | CC = pathogenic for Pyruvate dehydrogenase deficiency (important) |
| Thiamine (B1) | BCKDHB | i3002808 | C | — | Maple syrup urine disease, thiamine responsive (rare) |
| Thiamine (B1) | BCKDHB | rs386834233 | A | — | Maple syrup urine disease, thiamine responsive (rare) |
| Thiamine (B1) | BCKDHB | rs74103423 | A | — | Maple syrup urine disease, thiamine responsive (rare) |
| Choline | PEMT | rs7946 | T | — | Decreased PEMT activity, phosphatidylcholine |
| Choline | CHKA | rs10791957 | A | — | Reduced turnover of methionine to phosphatidylcholine |
| Choline | BHMT | rs3733890 | A | — | Decreased conversion of choline to betaine |
| Choline | FMO3 | rs2266782 | A | — | Choline used less as a methyl donor |
| Choline | MTHFD1 | rs2236225 | A | — | More likely to have choline deficiency (check diet) |
| Vitamin A | BCMO1 | rs7501331 | T | — | Decreased beta-carotene conversion to active form of vitamin A |
| Vitamin A | BCMO1 | rs12934922 | T | — | Decreased beta-carotene conversion to active form of vitamin A |
| Vitamin A | BCMO1 | rs11645428 | G | — | Decreased beta-carotene conversion to active form of vitamin A |
| Vitamin A | BCMO1 | rs6420424 | A | — | Decreased beta-carotene conversion to active form of vitamin A |
| Vitamin A | BCMO1 | rs6564851 | G | — | Decreased beta-carotene conversion to active form of vitamin A |
| Vitamin D | CYP2R1 | rs2060793 | A | — | Lower vitamin D levels |
| Vitamin D | CYP2R1 | rs1562902 | T | — | Higher vitamin D levels |
| Vitamin D | CYP27B1 | rs28934607 | A | — | Pathogenic for vitamin D related rickets (important) |
| Vitamin D | CYP27B1 | rs28934605 | T | — | Pathogenic for vitamin D related rickets (important) |
| Vitamin D | CYP27B1 | rs28934604 | T | — | Pathogenic for vitamin D related rickets (important) |
| Vitamin D | GC | rs2282679 | G | — | Lower vitamin D levels |
| Vitamin D | GC | rs7041 | A | — | Lower vitamin D levels |
| Vitamin D | VDR | rs731236 | A | — | Lower vitamin D levels, VDR-Taql |
| Vitamin D | VDR | rs1544410 | T | — | Lower vitamin D levels, VDR-Bsml |
| Vitamin D | VDR | rs2228570 | G | — | Lower vitamin D levels, VDR Fokl |
| Vitamin D | VDR | rs7975232 | C | — | VDR Apal variant |
| Folic Acid Conversion | DHFR | rs70991108 | D | — | More unmetabolized folic acid in blood |
| Folic Acid Conversion | DHFR | rs1677693 | T | — | Affects folic acid metabolism; folic acid supplementation may increase colon cancer risk |
| Folic Acid Conversion | DHFR | rs1650697 | A | — | Decreased conversion of folic acid, alters methotrexate response |
| Folic Acid Conversion | MTHFR | rs1801133 | A | — | Reduced MTHFR efficiency, may need more folate, B12 |
| Vitamin K | CYP4F2 | rs2108622 | T | — | Reduced CYP4F2, possibly __ warfarin dosage |
| Vitamin K | CYP4F2 | rs1558139 | A | — | Lower risk of stroke (inc. vit. K) |
| Vitamin K | VKORC1 | rs9934438 | G | — | Decreased VKORC1 |
| Selenium | SEP15 | rs5845 | A | — | Decreased selenium transport; increased risk of lung cancer in people with lower selenium levels, lower verbal memory scores |
| Selenium | SEP15 | rs561104 | C | — | Decreased FMO3, which breaks down nitrogen-containing amines. Some people helped with riboflavin. |
| Selenium | SEPP1 | rs7579 | T | — | Lower serum selenium levels, increased risk of prostate cancer |
| Selenium | SEPP1 | rs3877899 | T | — | Lower serum selenium levels |
| Selenium | SELENOS | rs34713741 | T | — | Increased risk of colon and gastric cancers |
| Selenium | GPX4 | rs713041 | T | — | Altered GPX4 function, increased risk of colon cancer or breast cancer with low selenium |
| Selenium | GPX1 | rs1050450 | A | — | Lower GPX enzyme activity |
| MTHFR Beyond C677T and A1298C | MTHFR | rs2274976 | T | — | Decreased folate conversion; increased risk of cleft lip, schizophrenia, high homocysteine |
| MTHFR Beyond C677T and A1298C | MTHFR | rs9651118 | C | — | Decreased risk of liver cancer, lower homocysteine (good) |
| MTHFR Beyond C677T and A1298C | MTHFR | rs13306560 | T | — | Lower blood pressure, protective against Parkinson’s (good) |
| MTHFR Beyond C677T and A1298C | MTHFR | rs17367504 | G | — | Protective against hypertension and preeclampsia (good) |
| MTHFR Beyond C677T and A1298C | MTHFR | rs4846049 | G | — | GG: Decreased risk of migraines (good) |
Disclaimer: The information provided in the report and by Genetic Lifehacks is for informational purposes only. It is not intended to diagnose or treat any disease. Please visit GeneticLifehacks.com for more detailed information plus complete references.
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