Study: MWF of the corpus callosum is a robust measure of remyelination: Results from the ReBUILD trial Published: PNAS, May 2023 Overview: The study included 50 multiple sclerosis (MS patients) and looked at the brain regions that are rich in myelin. In MS, the body attacks the myelin sheath. The study looked at ways to assess the therapeutic effect of compounds on the remyelination of neurons through imaging. While important for researchers to know the best MRI imaging biomarkers, what I found interesting is the effect on myelin from a first-generation anti-histamine, clemastine. MRI scans were done at baseline, 3 months and 5 months. Half of the patients received clematine and the other half a placebo from months 3 to 5. The results showed that clemastine stimulated the differentiation of stem cells that make myelin. This isn’t the first study on clemastine showing positive results for people with MS. However, it is important in that it shows how and where the remyelination is taking place. Clemastine used to be available OTC in the US as Dayhist Allergy and …
Article: Speech- and language-linked FOXP2 mutation targets protein motors in striatal neurons Published: May 2023, Journal Brain Summary: Human speech and language are very complex, and scientists have discovered a gene mutation called FOXP2 in some people with speech problems. The details of how this mutation affects speech have been unclear. Recent research using mouse models found that the FOXP2 mutation disrupts the workings of specific protein motors inside brain cells, leading to issues with cell growth and electrical activity. This disruption is linked to difficulties with vocalization. By reducing the level of a certain protein in mice with the FOXP2 mutation, researchers were able to improve their vocalization. This study suggests that FOXP2 controls the formation of speech-related brain circuits by managing the balance of protein motors in certain brain cells, and that its disruption could contribute to speech disorders associated with the FOXP2 mutation. Note: One FOXP2 mutation linked to severe speech development disorders is rs121908378 (AncestryDNA) or i5003781 (23andMe v4). R328X
PRO Member report summarizing rare mutation genotypes.
Pro Member step-by-step instructions to help clients (or yourself) with some of the technical aspects of membership.
Wondering what to look for on the vitamins and foods cheat sheet? Here are a few examples of how nutrigenomics (nutrition + genomics) can impact someone.
PRO Member report summarizing trait genotypes.
PRO Member report summarizing exercise genotypes.
PRO Member report that shows the complete overview of genotypes from all topics offered.
PRO Members summary overview of fertility-related genetic variants.
PRO Members summary report for longevity variants.
PRO Member report summarizing immune system genotypes.
PRO Member report on sleep and circadian rhythm genetic variants.
PRO Members summary report on disease-related genetic variants.
PRO Member report summarizing autoimmune genotypes.
PRO Member report summarizing detoxification genotypes.
PRO Member report summarizing gut health genotypes.
PRO Member report summarizing metabolic health genotypes.
PRO Member report showing overview of genotypes related to higher levels of inflammation.
PRO Member report summarizing mood and brain genotypes.
A printable guide for the genetic risk factors of diabetes. It includes specific genotypes that influence the risk of diabetes, along with possible lifestyle changes that can be implemented for better outcomes.