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News and Research: MS, remyelination, and an OTC antihistamine

Study: MWF of the corpus callosum is a robust measure of remyelination: Results from the ReBUILD trial Published: PNAS, May 2023 Overview: The study included 50 multiple sclerosis (MS patients) and looked at the brain regions that are rich in myelin.  In MS, the body attacks the myelin sheath. The study looked at ways to assess the therapeutic effect of compounds on the remyelination of neurons through imaging.  While important for researchers to know the best MRI imaging biomarkers, what I found interesting is the effect on myelin from a first-generation anti-histamine, clemastine. MRI scans were done at baseline, 3 months and 5 months. Half of the patients received clematine and the other half a placebo from months 3 to 5. The results showed that clemastine stimulated the differentiation of stem cells that make myelin.   This isn’t the first study on clemastine showing positive results for people with MS.  However, it is important in that it shows how and where the remyelination is taking place.   Clemastine used to be available OTC in the US as Dayhist Allergy and … Read more

News and Research: Apraxia Gene Mutation Discovered

Article: Speech- and language-linked FOXP2 mutation targets protein motors in striatal neurons Published: May 2023, Journal Brain Summary: Human speech and language are very complex, and scientists have discovered a gene mutation called FOXP2 in some people with speech problems. The details of how this mutation affects speech have been unclear. Recent research using mouse models found that the FOXP2 mutation disrupts the workings of specific protein motors inside brain cells, leading to issues with cell growth and electrical activity. This disruption is linked to difficulties with vocalization. By reducing the level of a certain protein in mice with the FOXP2 mutation, researchers were able to improve their vocalization. This study suggests that FOXP2 controls the formation of speech-related brain circuits by managing the balance of protein motors in certain brain cells, and that its disruption could contribute to speech disorders associated with the FOXP2 mutation.     Note: One FOXP2 mutation linked to severe speech development disorders is rs121908378 (AncestryDNA) or i5003781 (23andMe v4). R328X

PRO: Supplement Research Connections

Pro Member resource guide to help navigate popular supplements concerning genetic variants and health topics. You will find links to all corresponding articles to help you narrow down areas of interest.

PRO Members: Learning Resources

As a busy professional, your time is precious. These learning resources are designed to give you the essentials in a fast, visual format.

PRO Member: Tools and Printables

Pro Member exclusive access to all the printables and tools needed for a comprehensive approach to the health and wellness of your clients.

Case Examples: Nutrigenomics

Wondering what to look for on the vitamins and foods cheat sheet? Here are a few examples of how nutrigenomics (nutrition + genomics) can impact someone.