Inflammation and Immune Response

Genetics plays a huge role in your immune response — from how you fight off diseases to chronically increased inflammation.

Looking for information on an autoimmune disease? Check out these autoimmune articles.

Members: Check out the Inflammation Summary Report  and Immune System Summary Report for a quick overview of which articles apply to your genes.

Low IgA and Selective IgA Deficiency

Partial IgA deficiency, which affects up to 1% of the population, can have a genetic component and overlaps with some autoimmune diseases.

Lymphedema: Causes and Genetic Pathways

Lymphedema can be caused by various factors such as a traumatic injury, genetics, or even cancer. Discover how your genetics influence the risk of developing the condition.

Flu season

Beating Flu Season

Are you more genetically susceptible to the flu? Learn how your genes play a role and discover research-backed natural options to beat the flu.

Estrogen, histamine, and mast cell connections

Mast cells can be more easily triggered in the presence of high estrogen or estrogen-mimicking compounds. Histamine can also trigger mast cell degranulation. Together, this can cause a lot of symptoms related to mast cell activation.

IL13 Genomics: Elevating Th2 Immune Response

Interleukin-13 (IL-13) is a signaling molecule important in the immune response. Excessive IL-13 can tip you toward a Th2-dominant immune response, and variants increase the risk of allergies and asthma.

Tendinitis Genes

Do you have problems with your tennis elbow, rotator cuff, knees, or Achilles tendon? Discover how your genes influence the risk of having tendon problems.

APOBEC3 Family of Genes

The APOBEC3 family of enzymes has a unique way of stopping viruses from replicating. Your genes can affect whether the virus becomes inactive or more virulent.

Spike Protein, Mast Cells, Histamine, and Heart Rhythms

Do you know of someone with unexplained heart palpitations, spiking blood pressure, dizziness, and tinnitus? Discover how research is linking these symptoms to histamine, mast cells, and the spike protein.

Alopecia Areata: Reasons for Rapid Hair Loss

Alopecia areata is an autoimmune-like disorder in which the immune system attacks the hair follicle. Learn about the triggers of alopecia areata, why the hair falls out, genetic variants that increase susceptibility, and possible treatment options.

Causes of fatigue, with personalized solutions

Are you always tired even when you know you slept well? Discover more about the newest research on fatigue and how genetic susceptibility plays a part for some people.

HIV mutation

Mutation that blocks you from getting AIDS or HIV

The CCR5 gene is an important player in the immune response. A mutation in the CCR5 gene, called the Delta32 mutation, significantly reduces the chance of an HIV infection.

Zinc genes: The healing power of zinc

Learn why zinc is important for your immune system and so much more. Find out how your genes impact your need for zinc and discover ways of boosting your zinc status. 

Are you genetically less likely to get the flu?

Have you ever wondered why some people never seem to get the flu when it is going around? Simply put, some people are just more susceptible to getting the flu than others. Learn more and see if you are more or less susceptible to the flu.

TLR7: Susceptibility to COVID-19

In recent research, mutations in TLR7 (a sensor in our innate immune system) might cause severe Covid-19 in a small minority of healthy people.