TLR7: Susceptibility to COVID-19
In recent research, mutations in TLR7 (a sensor in our innate immune system) might cause severe Covid-19 in a small minority of healthy people.
Immune System and Inflammation
Genetics plays a huge role in your immune response — from how you fight off diseases to chronically increased inflammation.
Learn how to use your genetic data to target chronic inflammation, and find out how important your genes are in which bacteria and viruses you are likely to be susceptible to.
Looking for information on an autoimmune disease? Check out these articles.
Member’s: Check out the Immune System and Inflammation Topic Summary Report for a quick overview which article apply to your genes.
NLRP3 Inflammasome, Genetics, and Chronic Inflammation
What makes people more susceptible to inflammatory chronic diseases? The root of the over-activation of inflammation for some people could be the NLRP3 inflammasome.
Genetics and Food Allergies
Do you have a food allergy? Discover how the combination of environmental factors and genetic susceptibility can shape individual reactions.
Vaccinations and the MTHFR mutation? (2021 update)
A lot of people use the MTHFR variants as a reason not to vaccinate their kids. Is there any science to back this up? See what the research says.
COVID-19 & Genetics: Who gets sick and why?
Not everyone gets sick when exposed to the SARS-CoV-2 virus. While there are many factors that come into play here, research points to genetics as playing a role. Several good genetic studies have recently been released showing which genes are important in COVID-19 susceptibility. Learn more and check your genes.
ADAMTS13 and VWF Genetic Variants: blood clots and thrombocytopenia
Genetic Variants involving the ADAMTS13 gene and VWF (von Willebrand Factor) can increase the risk of blood clots and thrombocytopenia.
Blood clots, platelets, and adenoviruses
A look into the role of platelets, their connection to blood clots, and a discussion of the research on adenovirus-vector therapy, thrombocytopenia, and platelet reactions.
How your genes increase the risk of histamine intolerance
Genetics plays a big role in how well your body breaks down histamine. You can use your genetic data to figure out if your genes are part of the reason why you have histamine intolerance. Knowing which genetic variants you carry leads to targeted solutions that are more likely to work for you.
G6PD Deficiency: How to check your genes
People who carry the genetic mutations that cause G6PD deficiency are at an increased risk for hemolytic anemia when taking quinine-based medications. This article is intended to be a ‘heads up’ for anyone who is considering using quinine or chloroquine without a doctor’s advice for COVID-19.
Is inflammation causing your depression and anxiety? Inflammation genes and mood
Discover why inflammation causes depression and how your genetic variants in inflammatory genes may play a role in depression or anxiety.
Genetics, Chronic Fatigue Syndrome, and Long Covid
A look into the science of the lingering effects triggered by viruses including chronic fatigue syndrome and long-haul viruses.
TNF-alpha: Inflammation and Your Genes
Do you feel like you are always dealing with inflammation? Joint pain, food sensitivity, etc? Perhaps you are genetically geared towards a higher inflammatory response. Tumor necrosis factor (TNF) is an inflammatory cytokine that acts as a signaling molecule in our immune system.
Zinc genes: The healing power of zinc
Learn why zinc is important for your immune system and so much more. Find out how your genes impact your need for zinc and discover ways of boosting your zinc status.
Immune System and Inflammation Topic Summary Report
Utilize our Immune and Inflammation Topic Summary Reports with your 23andMe or AncestryDNA genetic data to discover the articles most relevant to you. These summaries distill the complex information down into just a few words. Please refer to the linked articles for details and complete references. (Member’s article)
HMGB1 gene: inflammatory response protein important in sepsis and COVID-19
The HMGB1 protein has a unique role in activating the inflammatory response pathways. Increased HMGB1 levels will call up the troops for a big response to an infection. Discover how genetic variants of this protein vary the risk of cancer, inflammation, and sepsis to name a few.
Genetics and Mannose-Binding Lectin
Mannose-binding lectin, also known as mannose-binding protein, is involved in the body’s innate defense against infections. Find out how genetic variants in this system increase your susceptibility to specific pathogens.