Arginine: Genetics, Nitric Oxide, Immune Response, and Ammonia Clearance
Learn how ARG1 and ARG2 variants influence arginine levels, nitric oxide, and urea-cycle balance—plus food, L-arginine vs citrulline, and safety trade-offs.
Inflammation and Immune Response
Genetic variants influence our immune response, affecting both our ability to combat pathogens and our susceptibility to chronic inflammation. For example, we are all unique in our response to different pathogens. Certain variants in inflammatory cytokine genes, such as TNF-alpha, may increase susceptibility to chronic inflammatory conditions while at the same time increasing your ability to fight off specific viruses or bacteria.
You can use your genetic data to understand which pathways are likely involved for you, and then use the lifehacks sections to discover the right solution for your genes.
Where to start?Â
Summary Reports for Members:
| Inflammation Summary | Immune System Summary Report |
Latest articles about Inflammation and Immune Health:
TNF-alpha: Inflammation, Chronic Diseases, and Genetic Susceptibility
TNF-alpha is a key inflammatory cytokine linked to autoimmune, cardiovascular, mood, and neurodegenerative diseases. Learn how TNF gene variants affect your risk and potential natural TNF inhibitors.
TRPM3: The Ion Channel Behind Pain, Migraines, and ME/CFS
TRPM3 is a calcium ion channel involved in heat sensing, pain transmission, migraines, and immune function. Your TRPM3 gene variants may affect susceptibility to ME/CFS, long Covid, and chronic pain.
TRPV1 Gene: Receptor for Spicy Foods, Sensing Cold, and CBD Oil
Learn how the TRPV1 gene shapes your reaction to spicy foods, pain, temperature, neuroinflammation and CBD oil, plus see how your genetic variants may affect tolerance and health.
Candida Biology, Pathogenesis, and Genetic Susceptibility
Learn why genetic variants in IL‑17, TLRs, dectin‑1, MBL, FUT2, and STAT1 can make some people much more susceptible to chronic or severe Candida infections.
Genetics of Mannose-Binding Lectin (MBL) Deficiency
Mannose-binding lectin, also known as mannose-binding protein, is involved in the body’s innate defense against infections. Find out how genetic variants in this system increase your susceptibility to specific pathogens.
IL-2 Genetics and Immune Balance
IL-2 dysregulation affects long COVID, autoimmune diseases, and cancer therapy response. Learn about your IL-2 genetic variants and natural ways to support IL-2.
ME/CFS and Genetics: Chronic Fatigue Syndrome Genes, Immune Pathways, and Natural Solutions
Genetic variants in immune, mitochondrial, and inflammatory pathways (NK cells, NLRP3, interferon, complement, TRP channels) increase ME/CFS susceptibility. Check your genes and explore research-backed solutions.
T Cell Exhaustion in Long COVID, ME/CFS, and Cancer: Mechanisms and Solutions
T cell exhaustion reduces your immune response in chronic infections, long Covid, and cancer. Check your genes, read the new studies on interventions, and understand the mechanisms.
Histamine Intolerance Genetics: DAO & HNMT Genes, Supplements
Genetic variants in DAO and HNMT genes affect histamine breakdown. Check your AOC1, HNMT, and HDC genotype. Low-histamine diet, DAO supplements, and more.
Interleukin-15 (IL-15): Immune response, cancer, long Covid, and genetics
Learn how IL-15 influences NK cells and CD8+ T cells in the immune response to pathogens and cancers. Find out how your genetic variants influence IL-15 levels.
Trigger Points, Myofascial Pain Syndrome, and Underlying Causes
Trigger points are hyperirritated knots in the muscle and fascia that can refer pain to a nearby region of the body.
POTS: Genetics, Causes, and Solutions for Postural Orthostatic Tachycardia Syndrome
Explore the genetic basis of POTS, from HLA and norepinephrine transporter variants to EDS, MCAS, and long Covid connections, plus strategies to better manage symptoms.
IL-13: Elevating Th2 Immune Response and Asthma risk
Interleukin-13 (IL-13) is a signaling molecule important in the immune response. Excessive IL-13 can tip you toward a Th2-dominant immune response, and variants increase the risk of allergies and asthma.
Inflammation as a Cause of Depression and Anxiety
Discover why inflammation causes depression and how your genetic variants in inflammatory genes may play a role in depression or anxiety.
NLRP3: Genetic Variants that Increase Chronic Inflammation
Explore NLRP3 inflammasome genetics: How variants drive chronic inflammation in Alzheimer’s, diabetes, and autoimmune diseases. Discover triggers, health risks, and lifehacks like zinc & vitamin D to modulate it.
Specialized Pro-resolving Mediators (SPMs): The Resolution of Inflammation
The resolution of inflammation is an active process that depends on lipid mediators, called specialized pro-resolving mediators (SPMs).
Epstein-Barr Virus: Genetic Risks, Reactivation, and Chronic Illnesses
Epstein-Barr virus (EBV) impacts lifelong health, links to autoimmune diseases, genetic risk factors, and practical steps to reduce reactivation.
Mast Cells: MCAS, Genetics, and Solutions
Mast cells are essential to your innate immune system, defending against pathogens and allergens. For some people, mast cells can be triggered too easily, giving allergy-like responses to lots of different substances.
Alpha-Gal Syndrome: Meat Allergy, Tick Bites, and Genetics
Alpha-gal syndrome causes allergic reactions to meat (beef, pork, lamb) after being bitten by a tick. Find out why and which genetic pathways are involved.
FUT2: Check to See if You Are a Secretor or Non-Secretor
A genetic variant in the FUT2 gene controls whether or not you secrete your blood type into your saliva and other bodily fluids, such as your intestinal mucosa. This can alter the gut microbiome – but protect against Norovirus infections.
Are Cold Sores Genetic? Who Gets Them and Why
While many people carry the HSV virus, only about 30% will get cold sores. Genetics is one reason.
Migraine Solutions Tailored to Your Genes: Triggers, Treatments, and Tools
Discover how genetics, triggers, and personalized strategies shape migraine prevention and relief. Find actionable solutions based on your DNA.
Flu Season: Genetics and Your Immune Response
Are you more genetically susceptible to the flu? Learn how your genes play a role and discover research-backed natural options to beat the flu.
Hidradenitis Suppurativa: Genetic Causes and Possible Solutions
Hidradenitis suppurativa is caused by overactive inflammation and hyperkeratosis. Genetics plays a big role – along with environmental factors.