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Inflammation and Immune Response

Genetic variants influence our immune response, affecting both our ability to combat pathogens and our susceptibility to chronic inflammation. For example, we are all unique in our response to different pathogens. Certain variants in inflammatory cytokine genes, such as TNF-alpha, may increase susceptibility to chronic inflammatory conditions while at the same time increasing your ability to fight off specific viruses or bacteria.

You can use your genetic data to understand which pathways are likely involved for you, and then use the lifehacks sections to discover the right solution for your genes.

Where to start? 

Overview of chronic inflammation  TNF-alpha: Elevated inflammatory cytokines
Genes involved in fatigue The resolution of inflammation is an active process
Root causes of migraines Asthma and lung inflammation
NLRP3 Inflammasome Emulsifiers and gut inflammation

Summary Reports for Members:

Inflammation Summary Immune System Summary Report

Latest articles about Inflammation and Immune Health:

graphical abstract -TRPM3 genetic variants ME/CFS, long Covid

TRPM3: The Ion Channel Behind Pain, Migraines, and ME/CFS

TRPM3 is a calcium ion channel involved in heat sensing, pain transmission, migraines, and immune function. Your TRPM3 gene variants may affect susceptibility to ME/CFS, long Covid, and chronic pain.

How MBL2 gene variants reduce mannose-binding lectin and weaken the lectin complement pathway

Genetics of Mannose-Binding Lectin (MBL) Deficiency

Mannose-binding lectin, also known as mannose-binding protein, is involved in the body’s innate defense against infections. Find out how genetic variants in this system increase your susceptibility to specific pathogens.

How IL-2 balances immune attack against immune restraint through regulatory T cells

IL-2 Genetics and Immune Balance

IL-2 dysregulation affects long COVID, autoimmune diseases, and cancer therapy response. Learn about your IL-2 genetic variants and natural ways to support IL-2.

How IL-13 shifts the immune system toward a Th2 response, raising asthma and eczema risk

IL-13: Elevating Th2 Immune Response and Asthma risk

Interleukin-13 (IL-13) is a signaling molecule important in the immune response. Excessive IL-13 can tip you toward a Th2-dominant immune response, and variants increase the risk of allergies and asthma.

Illustration of the NLRP3 inflammasome and the chronic inflammation it drives

NLRP3: Genetic Variants that Increase Chronic Inflammation

Explore NLRP3 inflammasome genetics: How variants drive chronic inflammation in Alzheimer’s, diabetes, and autoimmune diseases. Discover triggers, health risks, and lifehacks like zinc & vitamin D to modulate it.

How mast cells release histamine and other mediators in mast cell activation syndrome, and the genetics that influence MCAS

Mast Cells: MCAS, Genetics, and Solutions

Mast cells are essential to your innate immune system, defending against pathogens and allergens. For some people, mast cells can be triggered too easily, giving allergy-like responses to lots of different substances.

Comparison of secretor and non-secretor status and how FUT2 changes what appears in body secretions

FUT2: Check to See if You Are a Secretor or Non-Secretor

A genetic variant in the FUT2 gene controls whether or not you secrete your blood type into your saliva and other bodily fluids, such as your intestinal mucosa. This can alter the gut microbiome – but protect against Norovirus infections.