Are you a non-secretor? How to check your secretor status on 23andMe or AncestryDNA

Your genes control the species of bacteria that live in your gut microbiome. And your gut microbiome can help defend against — or make you vulnerable to — chronic diseases.

A genetic variant in the FUT2 gene controls whether or not you secrete your blood type into your saliva and other bodily fluids, such as your intestinal mucosa.

Whether you secrete your blood type plays a big role in the type of bacteria that dwell in our gut microbiome. Sounds crazy? But this can have both positive and negative impacts. For example, being a ‘non-secretor’ protects you from getting the norovirus – a.k.a. the dreaded stomach flu.

Non-secretors, FUT2, and Bifidobacteria

First, let me explain a little bit of the background science on being a ‘secretor’ or ‘non-secretor’ of your blood type – and then I’ll explain how to check your 23andMe or AncestryDNA raw data file for this information.

Oligosaccharides and Blood Type:

Oligosaccharides are a carbohydrate that consists of three to nine monosaccharides (simple sugars). You may be familiar with oligosaccharides as prebiotics in supplements or in foods like chicory and Jerusalem artichokes.

Your body actually makes oligosaccharides as well, and one of those oligosaccharides is what makes up your ABO blood type. Yep – when you give blood and they tell you that you have Type A or Type B blood, this means that your body produces a specific oligosaccharide that is presented on your red blood cells.

ABO Blood Group Diagram. Wikimedia Commons - Public Domain.
ABO Blood Group Diagram. Public Domain Image.

The FUT2 gene encodes the enzyme fucosyltransferase, which controls whether the oligosaccharides that make up your blood type will be expressed in your bodily fluids (other than your blood).

For the majority of people, the oligosaccharides that indicate your blood type are also found in your bodily fluids — which includes the mucous lining your intestines, sweat, vaginal mucosa, saliva, semen, and tears.

About 20% of Caucasian and African populations are non-secretors of their blood type. So what is the big deal? It turns out that being a non-secretor affects the way your body interacts with bacteria inside you.

Bifidobacteria

Researchers consider bifidobacteria to be one of the good guys when it comes to your gut microbiome. They are lactic and acetic acid-producing bacteria that help keep your immune system in check.

Bifidobacteria break down carbohydrates (specifically, oligosaccharides) from the foods you eat. They also chow down on the oligosaccharides produced by our body in the intestinal mucosa. That is where secreting your blood type (an oligosaccharide) comes into play.[ref][ref]


How to check to see if you are a non-secretor

A FUT2 non-secretor has a homozygous (two copies) change in the SNP rs601338.

Check your genetic data for rs601338 (23andMe v4, v5; AncestryDNA):

  •  G/G: blood type secretor
  •  A/G:  blood type secretor
  •  A/A:  non-secretor of blood type, lower amounts of bifidobacteria, resistant to norovirus

Effects of Being a Non-Secretor:

So what is the big deal about being a non-secretor?  Well, it comes back to our body’s interactions with the microbiome.

Non-secretor microbiome:

A 2011 study showed that non-secretors have significantly lower amounts of bifidobacteria in their gut microbiome. This makes sense because bifidobacteria are fed, in part, by the oligosaccharides in the intestinal mucosa. The same study showed that non-secretors also have a lower diversity of bacteria. [ref]  Another study in 2014 confirmed those findings.[ref]

B12 Levels in non-secretors:

Non-secretors also often have higher serum B12 levels. This may not truly reflect the amount of B12 that is being transported into the cells, so a test of methylmalonic acid may give you a better indication of your B12 status. [ref]

Oligosaccharides in breast milk:

An infant’s microbiome is, in part, colonized from the mother, and bifidobacteria usually make up a large part of an infant’s microbiome. Breastmilk contains oligosaccharides that feed the baby’s microbiome. Non-secretor mothers do not produce the 2′-FL oligosaccharide in their breastmilk, thus possibly impacting the baby’s microbiome.[ref]

Babies that are born via C-section to non-secretor mothers have altered microbiomes.[ref]

The effects on non-secretor status can also influence breastfed babies of non-secretor mothers. A 2015 study found that “Infants fed by non-secretor mothers are delayed in the establishment of a bifidobacteria-laden microbiota. This delay may be due to difficulties in the infant acquiring a species of bifidobacteria able to consume the specific milk oligosaccharides delivered by the mother.”[ref]

In other words, if your mom is a non-secretor, your gut microbiome may be altered a little bit.

Non-secretors are resistant to some infectious diseases:

Non-secretor status plays a role in infectious diseases as well. One big advantage of being a non-secretor is resistance to some viruses that cause what is commonly called the ‘stomach flu’.

  • The norovirus and the rotavirus are much, much less likely to infect a non-secretor.[ref][ref]
  • Children who are non-secretors are less likely to have diarrheal diseases.[ref]
  • H. pylori colonization is also less in non-secretors.[ref]

Non-secretors are at an increased risk for certain diseases:

Secretor status also plays a role in non-infectious diseases as well, possibly through interactions with the gut microbiome. Non-secretors have a higher risk of:

  • Type 1 diabetes[ref],
  • alcohol-induced pancreatitis[ref],
  • Crohn’s disease[ref], perhaps a greater risk for Chinese population groups[ref]
  • adverse outcomes in premature infants[ref]
  • symptoms from e. coli infections [ref]
  • slightly higher risk of the mumps [ref]

 

Japanese ancestry:

The rs601338 mutation for non-secretors is not found in Japanese populations, but another SNP codes for non-secretors for Japanese. If you are Japanese, check your genetic data for rs1047781 for the T/T genotype to see if you are a non-secretor.


Lifehacks

Probiotics containing bifidobacteria:

Several places on the internet mention that bifidobacteria-containing probiotics are good for non-secretors. RenewLife’s Ultimate Flora has a high count of several types of bifidobacteria. VSL #3 is another probiotic that has good reviews and contains bifidobacteria.

Prebiotics containing 2′-FL (2′-Fucosyllactose):

Mothers who are non-secretors do not produce the 2′-FL oligosaccharide in their breastmilk. This oligosaccharide is now available as a prebiotic via Amazon and other sources. (I’m not sure if the prebiotic is targeted towards adults or infants…) Various strains of bifidobacteria use 2′-FL as a food source, and those bifidobacteria then increase the amount of short-chain fatty acids produced in the gut microbiome.[ref] Thus combining bifidobacteria probiotics and a 2′-FL prebiotic may be beneficial for increasing short-chain fatty acids in the gut. (I’m making some assumptions here – but it may be worth trying if you are a non-secretor with gut problems…)

Gluten Sensitivity

One theory of why some people are gluten intolerant (without having Celiac) is that low levels of Bifidobacteria and Firmicutes cause alterations to the short-chain fatty acid composition in the gut. This then alters the mucosal barrier in the gut and increases the risk of gluten sensitivity. [ref]  If that theory is right, then probiotics containing bifidobacteria could help with gluten intolerance.

Microbiome sequencing:

If you want to know how many and what type of bifidobacteria are in your gut, you could do a microbiome sample from uBiome or American Gut.  Do read their privacy policies thoroughly before buying.

More to read:

 



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10 Comments on “Are you a non-secretor? How to check your secretor status on 23andMe or AncestryDNA

  1. Pingback: Genetic Lifehacks | Weight Loss Genetics – Obesity Virus?

  2. Pingback: Genetics of Celiac Disease

  3. Is it only rs 601338? I am ++ for rs492602 and rs602662 and I have no bifidobacterium and gut issues.

    • Hi Lisa,
      All three of those SNPs are inherited together for almost everyone. So if you have the risk alleles for rs492602 and rs602662, then you almost certainly also have the risk alleles for rs601338 and be a non-secretor.
      Thanks for commenting,
      Debbie

  4. I’m onlyi ++ for rs 492602 and I have no bifido either. 🙄
    Using prebiotics I have baloon in my gut😷

  5. This is a little off-topic but is the FUT2 variant what led the police to Joseph DeAngelo, the suspected Golden State Killer? Newspaper accounts refer to him as being a “non-secretor”.

    • I’ve read that he was a non-secretor and they couldn’t get his blood type from the semen sample.
      And yes, this FUT2 variant would be the cause of that.
      Thanks for reading and commenting :-)
      Debbie

  6. I’m a non-secretor! Woohoo! Is this linked to blood type, as my mother and I both have O rh- blood type and neither of us are secretors and neither of us get sick? I can basically lick anything and I never get so much as a mild stomach ache. I have maybe one cold every decade and only then if I’m seriously pushing myself (zero sleep, drink too much, mega stressed, living in damp/freezing conditions week in week out). But even then I don’t get stomach-based sickness. Whereas my brother and sister, who are O rh+ like my father and likely secretors (as he is), all get sick a lot more. My 23&me results say I have slightly increased risk for celiac, but I live on bread and pasta and it doesn’t seem to affect me (unlike my brother).

    • Hi Ellie –
      Thanks for reading and posting your comment and question!
      No, I don’t think that non-secretor status is tied to blood type in any way. But it is definitely tied to not getting the stomach-based sicknesses :-)
      Debbie

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