Fertility: How Your Genes Impact the Root Causes of Infertility

There are many possible reasons for infertility, and your doctor can help you rule out physical problems blocking conception. But when testing has eliminated all major problems, what do you do when you are left without a reason? Sometimes genetic variants can point you to the underlying causes and possible solutions. Check out the following articles to learn more about how common genetic variants can impair fertility.

Infertility, Genes, and Root Causes:

Genetic links to infertility for women ↗

Overview: Infertility can have several underlying causes, including nutrient deficiency, poor egg quality, blood clot susceptibility, and PCOS.

Genes: MTHFR, F5, IGBT3, LHCGR, DENDD1A, FSHR, FSHB, MTNR1B

 

Genetics, inflammatory cytokines, and recurrent miscarriage ↗

Overview: This article focuses on the role of inflammation and how it impacts pregnancy. We will dive into several different inflammatory cytokines and look at the genetic variants that increase or decrease the risk of recurrent miscarriage.

Genes: IL17, IL1B, TNF, IL10

 

Genetic Causes of Male Infertility ↗

Overview: Many different genetic variants can increase the risk of infertility in men. These variants impact different aspects of sperm production – from hormones to oxidative stress to DNA damage repair. My goal here is to help you understand where you are more likely to have genetic susceptibility to infertility. Understanding this connection can help you target the right lifestyle interventions and supplements.

Genes: CFTR, PRM1, LIG4, TGFB3, GSTM1, HSPA1L, NOS3, MTHFR, MTRR, FSHR, HFE

 

Choline ↗

Overview:  Choline is an essential nutrient often lacking in the diet. It is especially important in fertility and for the developing baby.

Genes: MTHFD1, PEMT, SLC44A1, CHKA, PCYT1A

 

Dads matter: MTHFR variants in fathers affect miscarriage risk↗

Overview:  While the MTHFR variant is often associated with maternal fertility issues, it can also affect sperm formation. What’s important here is that diet and lifestyle changes can help.

Genes: MTHFR


About the Author:
Debbie Moon is the founder of Genetic Lifehacks. Fascinated by the connections between genes, diet, and health, her goal is to help you understand how to apply genetics to your diet and lifestyle decisions. Debbie has a BS in engineering and an MSc in biological sciences from Clemson University. Debbie combines an engineering mindset with a biological systems approach to help you understand how genetic differences impact your optimal health.