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Depression, Genetics, and Mitochondrial Function

Depression, Genetics, and Mitochondrial Function

How does mitochondrial dysfunction relate to major depressive disorder? Learn about the causes of mitochondrial dysfunction as well as genetic variants that link the risk of depression to the mitochondria.

MTHFR variants and depression and anxiety

MTHFR, Depression, Anxiety, Symptoms and Treatment

We are all genetically unique, and a common genetic variant in the MTHFR gene causes some people to be more susceptible to having low folate levels. This article explains the research linking MTHFR variants, folate, and depression — and gives you information on how diet or supplements may help.

Circadian Rhythm Disruption as a Cause of Repression

Circadian Rhythm Disruption as a Root Cause of Depression

For some people, circadian disruption can be chronic – and at the heart of depression or mood disorders. Genetic variants play a role in this susceptibility. Fortunately, there are solutions that may help. ​

Bipolar Disorder, Depression, and Circadian Clock Genes

Bipolar Disorder, Depression, and Circadian Clock Genes

New research shows that depression and bipolar disorder are linked to changes or disruption in circadian genes. Some people carry genetic variants in the circadian genes that make them more susceptible to circadian disruption.

Mast cell activation syndrome genetics and solutions

Mast Cells: MCAS, Genetics, and Solutions

Mast cells are essential to your innate immune system, defending against pathogens and allergens. For some people, mast cells can be triggered too easily, giving allergy-like responses to lots of different substances.

New research on FTO gene variants, FTO and heart disease, viral susceptibility

FTO and m6A Methylation

Recently, researchers discovered that FTO is an m6A eraser that removes methyl groups from mRNA. This discovery has opened up huge avenues of research on topics from cancer to immune response to heart disease.

Glutamate Receptors and Transporters

Glutamate Receptors and Transporters

Glutamate transporters and receptors carefully balance glutamate levels in the brain. Variants in the glutamate genes can affect how your brain balances glutamate.

Genetic variants that cause Hemochromatosis, symptoms of Hemochromatosis

Building Up Iron: Hemochromatosis Mutations

A couple of common mutations can cause you to build up iron, leading to iron overload or hemochromatosis. It is one genetic disease where knowledge is really powerful – you can completely prevent hemochromatosis through blood donations.

miRNAs control gene expression by blocking translation of mRNA into the protein.

miRNA: What It Is and How It Works

miRNAs are small non-coding RNA molecules that regulate gene expression. They are important for healthy aging, longevity, metabolic health, and immune function.

Opioid Receptor Genetic Variants and Addiction

Opioid Receptors Genetic Variants and Addiction

Genetic variants in the ORPM1 gene impact both the amount of pain someone experiences and their response to opioid drugs. These variants are also important in susceptibility to opiate addiction. (Member’s article)

Supplements with genetic connections

Supplements with Genetic Connections

Linking supplements and genetic SNPs so that you can more easily find out what may work for you – and what to be cautious about.

New genome wide study on long covid

Long Covid: 23andMe Genome Wide Association Study

BookmarkA new preprint study looks at the genetic variants more commonly found in people with Long Covid. This is encouraging for many people struggling with long Covid symptoms, raising hopes that understanding the genetic susceptibility will lead to much-needed treatments. Let’s look at how the study was done and what … Read more