Biological Age Calculators

The idea of biological age is that it shows how your lifestyle and genetics interact to estimate your cellular age more accurately than what the calendar says (chronological age).  These biological age calculators are based on algorithms created using large population data sets and mortality outcomes.

Calculators for predicting biological age:

1)Aging.ai – You can input your basic blood test biomarkers along with age and weight. It will predict your biological age.  The information on how it is calculated is included in this research paper: https://academic.oup.com/biomedgerontology/article/73/11/1482/4801287

2) There is a second way of predicting biological age based on blood test biomarkers. The calculator is available on Google Drive. You will need to download it and open it in Excel or Google Sheets to use it.  It is based on this research paper: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312200/. Here is a slideshow that explains the algorithm with pretty charts.  This calculator isn’t as pretty as the aging.ai interface, but it supposed to be more accurate. The ‘Ptypic Age’ result in the bottom row of the spreadsheet is giving you your phenotypical age. This basically correlates your mortality risk to the ‘phenotypical age’ — so if your phenotypical age is 50, your statistical mortality risk would be that of a 50-year-old.

For me, the two calculators came up with different biological or phenotypical ages (aging.ai says 34 and the ptypic age calculator says 38).  I was using blood work from a couple of years ago, so I would have been 46 when I got it done.  (I think the aging.ai may be skewed a lot for me since I benefit from a PCSK9 variant that lowers cholesterol.)

3) Frailty Index – This article includes (towards the bottom) an old-school way to calculate your age by adding up your score for the “Frailty Index”. The concept is based on this 2017 study on aging.

 


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About the Author:
Debbie Moon is the founder of Genetic Lifehacks. Fascinated by the connections between genes, diet, and health, her goal is to help you understand how to apply genetics to your diet and lifestyle decisions. Debbie has a BS in engineering and an MSc in biological sciences from Clemson University. Debbie combines an engineering mindset with a biological systems approach to help you understand how genetic differences impact your optimal health.