DEC2 Gene: Short Sleep Mutation

For optimal health, most people require approximately 8 hours of sleep. Short nights are taxing on the body, leaving you susceptible to infection, inflammation, and chronic health issues.

When you look at sleep advice from health websites, they almost all say “get around 8 hours a night”. But this website is all about personalization and getting away from stock advice. So let’s look at one genetic mutation that causes a person to require less sleep.

Sleep duration and the DEC2 / BHLHE41 gene mutation

I always find the outliers interesting: The people with genetic variants that cause a deviation from the norm, such as centenarians with longevity variants.

We are all unique, and one-size-fits-all advice doesn’t always apply. One example of this is the idea that everyone needs 8 hours of sleep a night.

While most of us do best with around 8 hours of sleep, a genetic mutation in the DEC2 gene that causes some people to be perfectly fine with about 1.5 hours less sleep each night.

This means that people with the mutation average 6 to 6.5 hours of sleep. And the kicker is that there are no known negative effects from this!

Just imagine… over the course of a year that would be almost 550 hours not spent sleeping. You could take up a new hobby, read dozens of more books, learn a foreign language, or just have more fun.

What does the DEC2 gene do?

Another name for DEC2 is BHLHE41 (the official gene name).[ref]

The DEC2 gene encodes a protein that affects gene transcription of core circadian rhythm genes.[ref]

Your circadian rhythm is the built-in 24-hour clock that controls the function of lots of things in your body. In addition to impacting your need for sleep at night, the core circadian clock controls when your immune system is most active, how hormones are released over the course of a day, and your body temperature. In fact, your circadian rhythm controls the expression of about 40% of genes in the body.

Research also points to BHLHE41 (DEC2) being important in immune response and cancer prevention, through its role as a gene transcription regulator. Cell studies show that increased DEC2 can inhibit cancer cell proliferation, and a decrease in DEC2 is associated with more cancer growth in certain cancer types. It isn’t completely straightforward that more DEC2 is good – it depends on the type of cancer.[ref]

DEC2 and Orexin:
Recently, researchers found that BHLHE41 also impacts orexin levels. Orexin is is a hormone that acts in the hypothalamus to cause wakefulness as well as impacting mood, appetite, and reward. Problems in the orexin system are the cause of narcolepsy.[ref]

DEC2 may also play a role in periodontal health through regulating immune response in gum disease. A recent study using mice with low DEC2 levels showed that the animals had higher levels of proinflammatory cytokines and autophagy. [ref]


DEC2 Short Sleep Genotype Report

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How to check your DEC2 gene in 23andMe or AncestryDNA:

BHLHE41 (DEC2) gene:

Check your genetic data for rs121912617 P385R (23andMe v5; AncestryDNA):

  • G/G: typical
  • G/T: natural short sleeper (less than 0.5% of population)[ref]
  • T/T: natural short sleeper (really, really rare)

Members: Your genotype for rs121912617 is .

Quick note: SNPedia.com and a couple other sources list the C allele as the mutation, but there are multiple mutation alleles listed for this specific rs id. I’ve gone with dbSNP here in listing the T allele as the mutation because it matches with the frequency in the population.

How rare is the DEC2 mutation?

The DEC2 mutation is found in less than 0.5% of the population. One commonly used genome estimate shows that the DEC2 mutation was found in just 2 people out of over 10,000.  [ref]image showing one guy in a crowd to indicate DEC2 mutations are really rare

Are there other genetic mutations that cause short sleep?

Another rare DEC2 mutation has been found by researchers. It is known as Tyr362His and does not have an rs id number yet.[ref]

Researchers also recently found a rare mutation in the ARDB1 gene that also seems to cause naturally shorter sleep.[ref] This rare mutation does not seem to be covered in 23andMe or AncestryDNA data.

The key takeaway here is that mutations that cause short sleep are rare, but they do exist.


Lifehacks for sleeping better:

If you are in the 0.5% of the population with this DEC2 mutation, then you can stop worrying about why you don’t need 8 hours of sleep :-)

For the rest of us, prioritizing 7.5+ hours of sleep is important.

Here are some sleep tips:

☑ Block blue light from electronics at night for several hours before bed. Seriously. This can help a lot! Blue light stops the production of melatonin, throwing off your circadian rhythm. You can use 100% blue-light blocking glasses if you aren’t willing to shut off electronics.

☑ Turn down the bright overhead light. Consider switching to lamps with bulbs that give off a yellow or orange light (sometimes called Edison bulbs).

☑ Sleep in a cool and dark room.

☑ Blackout curtains are a must if you live in an urban area with light pollution.

☑ Get out in the sunshine or bright light in the morning after you get up. This helps to reset your circadian rhythm and increases melatonin production at night.

☑ If you are a slow caffeine metabolizer, cut off caffeine by noon. Even if caffeine doesn’t keep you from falling asleep, for slow metabolizers, caffeine will still mess with your sleep quality.

Boosting orexin to need less sleep?

The research on orexin and the DEC2 mutation is interesting. Boosting orexin should theoretically lead to shorter sleep. Research points to several ways to boost orexin levels by a bit (not as much as the DEC2 mutants):

Get out in the sunlight: Animal studies show that exposure to sunlight increases orexin.[ref]

Decrease carbs at night: A drop in glucose levels stimulates orexin.[ref][ref] Going low-carb may prompt an increase in orexin, at least temporarily.
Something to experiment with: Eat dinner early or avoid carbs with dinner and see how it impacts your natural sleep requirement.

Go keto: A ketogenic diet increases orexin-A levels.[ref] (This may be why some people have trouble sleeping initially when going low-carb.)

Use common sense: Increasing orexin in order to sleep less may not be the best idea. Sometimes sleeping 7.5 – 8 hours a night really is the best thing for your mental and physical health.

 


Related Articles and Topics:

Increased Slow Wave Sleep:
A genetic variant in the ADA gene causes people to typically have more deep, slow-wave sleep.

Sleep Report:
A quick overview of how your genetic variants impact various aspects of sleep including insomnia, circadian rhythm, and sleep quality.

Depression, Genetics, and Circadian Rhythm:
Your genetic variants in your circadian rhythm genes impact your susceptibility to depression, anxiety, and bipolar disorder.


About the Author:
Debbie Moon is the founder of Genetic Lifehacks. Fascinated by the connections between genes, diet, and health, her goal is to help you understand how to apply genetics to your diet and lifestyle decisions. Debbie has a BS in engineering and also an MSc in biological sciences from Clemson University. Debbie combines an engineering mindset with a biological systems approach to help you understand how genetic differences impact your optimal health.