Do your genes play a role in how much you weigh? Absolutely! But before you get all excited about blaming genetics for being overweight, lifestyle factors such as diet, meal timing, and exercise are also really important.
This weight loss genotype report shows you how your genes may impact your weight – and specific options to tackle the pathways. We are all different, and a one-size-fits-all approach to weight loss does not work for everyone.
Let’s be honest here: Weight loss takes some hard work, and there are no magic pills based on genetics. Instead, understanding the science may help you to figure out your best path towards a healthy weight for you.
Genetics and Weight:
Research shows that about 60% of obesity susceptibility is due to genetic differences. Combining waist circumference measurements along with BMI increases the genetic component to 77%.[ref][ref]
- Single gene mutations: A handful of rare genetic mutations cause extreme obesity, beginning in early childhood. (Not included here.)
- Multiple genetic variants: For most people, the genetic component of weight is due to the combination of more common genetic variants that add together to promote weight gain, especially in an environment abundant with tasty foods.[ref]
Genetics can show us why we gain weight easily.
The variants below are organized by three icons – for appetite, circadian rhythm, and energy usage.
Many genetic variants related to obesity are linked to the appetite control center in the brain. Leptin (satiety signal) and ghrelin (hunger hormone) are two key hormones regulating appetite, and genes influencing their levels are linked to weight gain.
Several obesity-related genetic variants are important in circadian rhythm, the 24-hour built-in clock system in the body. Meal timing is important for weight management – for some people.
A couple of the genetic variants are related to how the body expends energy. Some people burn more calories, and some people react differently to using fat for fuel.
Weight Genotype Report:
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Debbie Moon is the founder of Genetic Lifehacks. Fascinated by the connections between genes, diet, and health, her goal is to help you understand how to apply genetics to your diet and lifestyle decisions. Debbie has a BS in engineering and also an MSc in biological sciences from Clemson University. Debbie combines an engineering mindset with a biological systems approach to help you understand how genetic differences impact your optimal health.