Diabetes

Decrease Your Risk of Diabetes – Using Genetics

What comes to mind as far as the risk of type 2 diabetes? Usually first up is the mental picture of someone eating donuts and slurping down soft drinks.  While diet definitely contributes to diabetes risk, not everyone who eats donuts and slurps soft drinks will get diabetes. Alternatively, not everyone with type 2 diabetes got it through poor dietary choices. Obviously, the must be more to diabetes than just poor dietary choices. (Don't get me wrong - you should still make good dietary choices...) Genetics plays a role in diabetes, as anyone who has several diabetics in their family well knows.  This is a big, broad topic, though, since there isn't just one gene that causes diabetes or even one way that people can have problems with regulating their blood sugar. (more…)

By Debbie Moon, ago
Diabetes

Are you at a higher risk for diabetes? Check your TCFL72 variants

Type-2 diabetes affects about 9% of the US population and millions other world-wide. In those over age 65, one in four people has type-2 diabetes. While the overall numbers are a bit staggering, it is interesting to note that the peak for new cases was in the '90s with a decrease in cases from 2005-2017.[ref] Diabetes is thought to be caused partly by environment and partly due to genetics. Genetic susceptibility has been linked to a number of different genes, but one that stands out as being particularly relevant to almost all populations is the TCF7L2 gene. The TCF7L2 (transcription factor 7-like 2) gene is involved in the regulation of blood glucose level with insulin by affecting the expression of pro-glucagon.  Variants in TCFL2 are tied to type-2 diabetes, obesity, higher BMI,  and larger waist circumference. The SNPs listed below have been found to up-regulate TCF7L2 in pancreatic beta cells.[ref]  The up-regulation is thought to impair insulin secretion from the beta cells rather than causing insulin resistance. [ref] [ref] Why is this important? If you have one of the TCF7L2 variants that increase your risk of diabetes, there are lifestyle and diet choices that have been shown in studies to negate that increased risk. (more…)

By Debbie Moon, ago
Circadian Rhythm

PPARG: A genetic variant that can protect against obesity and type-2 diabetes, but only if you eat the right diet.

The PPARG (peroxisome proliferator-activated receptor gamma) gene has been associated with obesity, metabolic syndrome, and risk for type-2 diabetes. This gene is involved in the regulation of fatty acid storage and in glucose metabolism. PPAR-gamma is activated by omega-6 polyunsaturated fatty acids and regulates adipocyte differentiation. More specifically, PPARG is a nuclear transcription factor that involved in our natural circadian rhythm, regulating genes involved in storing fat and insulin sensitivity over a 24-hour cycle.[ref] (more…)

By Debbie Moon, ago


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