MTR / MTRR – Homocysteine, methionine, and B12

MTR (methionine synthase) and MTRR (methionine synthase reductase) are two genes involved in the conversion of homocysteine to methionine, and a couple of fairly common gene variants cause the genes to work differently. Why is this something to care about? Methionine is an essential…

COMT – A gene that affects your neurotransmitter levels

COMT gene function: The¬†COMT gene codes for the enzyme catechol-O-methyltransferase which breaks down (metabolizes) the neurotransmitters¬†dopamine, epinephrine, and norepinephrine. This enzyme adds a methyl group from SAMe to the dopamine, epinephrine, or norepinephrine molecules, thus changing them into a different substance. COMT is also…

Histamine intolerance and the methylation cycle

Histamine is a molecule that plays many roles in the body. It is involved in allergic reactions, plays a role in our immune defense system, acts as a vasodilator, and is a neurotransmitter.¬† While most of us think of histamine only when reaching for…