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Circadian Rhythm Disruption as a Cause of Repression

Circadian Rhythm Disruption as a Root Cause of Depression

For some people, circadian disruption can be chronic – and at the heart of depression or mood disorders. Genetic variants play a role in this susceptibility. Fortunately, there are solutions that may help. ​

COMT Graphical Abstract, Slow COMT effects, Slow COMT

COMT Gene: Neurotransmitter Levels, Estrogen Metabolism, and SNPs

Wondering why your neurotransmitters are out of balance? It could be due to your COMT genetic variants. The COMT gene codes for the enzyme catechol-O-methyltransferase which breaks down (metabolizes) the neurotransmitters dopamine, epinephrine, and norepinephrine.

Bipolar Disorder, Depression, and Circadian Clock Genes

Bipolar Disorder, Depression, and Circadian Clock Genes

New research shows that depression and bipolar disorder are linked to changes or disruption in circadian genes. Some people carry genetic variants in the circadian genes that make them more susceptible to circadian disruption.

BDNF Val66Met, The Interaction Between BDNF and Serotonin

The Interaction Between BDNF and Serotonin

Genetic variants in the BDNF and serotonin receptor genes combine to increase the risk of depression and anxiety. Learn more about BDNF and how these variants interact — and check your genetic data to see how this applies to you.

Circadian Rhythm Disruption and Mood Disorders

Circadian Rhythm Genes: Mood Disorders

Circadian rhythm disruption can drive mood disorders. Learn more about the genes involved and the ways to normalize your circadian rhythm.