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COMT: How to Optimize Your Supplements for Your COMT Genotype

Some supplements interact with COMT variants to impact the rate at which neurotransmitters are broken down. Check your COMT genotype and discover how this may affect your reaction to different supplements or combinations of supplements.

HPA Axis Dysfunction: Understanding Cortisol and Genetic Interactions

Cortisol is a hormone produced by the adrenal glands in times of stress, and it also plays many roles in your normal bodily functions. It is a multi-purpose hormone that needs to be in the right amount (not too high, not too low) and at the right time. Your genes play a big role in how likely you are to have problems with cortisol.

Creatine Synthesis, Foods high in creatine, creatine benefits

Creatine: Boosting Muscles and Increasing Brain Power

Creatine is an amino acid used in muscle tissue and the brain for energy in times of stress. Genes play a role in creatine synthesis. Find out what the research shows about creatine supplements for muscle mass and cognitive function.

Pernicious Anemia: Genomics and B12 Deficiency

Pernicious anemia is a B-12 deficiency anemia caused by an autoimmune attack on the cells that produce intrinsic factor. Learn how genes impact susceptibility to pernicious anemia.

Tryptophan Pathways: Kynurenine, Serotonin, and Melatonin

Tryptophan is an amino acid that the body uses to make serotonin and melatonin. Genetic variants can impact the amount of tryptophan that is used for serotonin. This can influence mood, sleep, neurotransmitters, and immune response.

GABA: Genetics, Anxiety, and Immune Response

GABA (gamma-Aminobuyteric acid) is a neurotransmitter that acts to block or inhibit a neuron from firing. It is an essential way that the brain regulates impulses, and low GABA levels are linked with several conditions, including anxiety and PTSD.

Identify Your Root Cause(s) of Depression

Depression can have multiple physiological causes. This article ties together 9 separate articles on depression to simply your genetic search.

Heat Shock Proteins

Heat Shock Proteins: Cellular Resilience

Heat shock proteins are activated by cells in response to a stressful condition, such as exposure to high heat. Learn more about the essentials of heat shock proteins, including how to activate them and the genetic variants that impact how well they work.

featured image for an article on how genes impact serotonin levels.

Serotonin: How your genes affect this neurotransmitter

Serotonin is a neurotransmitter that is important in depression, sleep, and many other aspects of health. Learn how your genetic variants in the serotonin receptor genes impact their function.

Depression genes

Depression, genetics, and mitochondrial function

How does mitochondrial dysfunction relate to major depressive disorder? Learn about the causes of mitochondrial dysfunction as well as genetic variants that link the risk of depression to the mitochondria.

Rapamycin, mTOR, and Your Genes

Rapamycin is an antibiotic used as an immunosuppressant, an anti-cancer agent, and to prevent blocked arteries. Rapamycin is now the focus of longevity and healthspan-extending research by inhibiting mTOR.

MTHFR, depression, anxiety, symptoms and treatment

We are all genetically unique, and a common genetic variant in the MTHFR gene causes some people to be more susceptible to having low folate levels. This article explains the research linking MTHFR variants, folate, and depression — and gives you information on how diet or supplements may help.

CBD Oil: Will it work for you?

Why do some people get such great benefits from CBD while others notice nothing? Your genes play a role in how your body responds to CBD.

Circadian rhythm disruption as a root cause of depression

For some people, circadian disruption can be chronic – and at the heart of depression or mood disorders. Genetic variants play a role in this susceptibility. Fortunately, there are solutions that may help. ​

COMT Gene: Neurotransmitter levels and estrogen metabolism.

Wondering why your neurotransmitters are out of balance? It could be due to your COMT genetic variants. The COMT gene codes for the enzyme catechol-O-methyltransferase which breaks down (metabolizes) the neurotransmitters dopamine, epinephrine, and norepinephrine.

Bipolar Disorder, Depression, and Circadian Clock Genes

New research shows that depression and bipolar disorder are linked to changes or disruption in circadian genes. Some people carry genetic variants in the circadian genes that make them more susceptible to circadian disruption.

BDNF serotonin

The Interaction Between BDNF and Serotonin

Genetic variants in the BDNF and serotonin receptor genes combine to increase the risk of depression and anxiety. Learn more about BDNF and how these variants interact — and check your genetic data to see how this applies to you.