Chronic inflammation is the driver of many common diseases, such as heart attacks, diabetes, obesity, and autoimmune diseases. Measuring C-reactive protein (CRP) through a simple blood test is one way to know if you have chronic inflammation problems. It is an easy biomarker to test, and it gives you a way to quantify your inflammation level.
Some people have variants in the CRP gene that naturally elevate their CRP levels a little — others carry genetic variants that decrease their CRP levels. These differing effects can be essential if you track CRP as a health biomarker! Up to half of the variation seen in CRP levels is due to genetics.[ref]
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What is C-reactive Protein (CRP)?
Your liver produces C-reactive protein in response to both acute and chronic inflammatory conditions that cause a rise in IL-6.
Macrophages, a critical part of your body’s immune response, produce IL-6 in response to specific pathogens. So CRP rises in response to inflammation.
The “C” in C-reactive protein comes from the initial discovery that it was produced in response to the C polysaccharide found on the cell wall of pneumococcus bacteria. CRP binds to certain bacteria or dead cells as a marker that they need to be cleared out.
Elevated CRP levels:
Really high CRP levels can indicate an acute bacterial infection or injury/wound. CRP levels can rise 2,000-fold in just hours as an acute response to a pathogen. This response is an important way your body fights off invaders.
Chronically elevated CRP levels, though, are not a good thing. They indicate chronic inflammation linked to an increased risk of heart disease, depression, diabetes, obesity, and non-alcoholic fatty liver disease.[ref][ref][ref][ref][ref]
Normal CRP levels:
Normal C-reactive protein levels are between 1.0 and 3.0. Higher than 3.0 is considered ‘high’ and is used by doctors to determine heart health risk.
Is high CRP genetic?
Genetics plays a role in your propensity towards higher or lower baseline levels of CRP. For example, if your CRP level is on the high end of normal, it may be that genetically you tend to produce more CRP.
To some extent, the link between the genetic variants and disease helps to answer whether CRP is just a ‘marker of inflammation’ or plays a role in causing the disease.
- Genetic variants that lower CRP are linked to a decreased risk of certain chronic diseases that are thought to be caused by chronic inflammation.
- Variants that cause higher CRP are linked to increased risk of some chronic diseases, including cardiovascular disease.[ref]
Studies showing that CRP may be ‘causal’:
- In heart disease, CRP may be actively causing atherosclerosis (hardening of the arteries)[ref], thus the increased risk of heart disease.
- It is also theorized that higher CRP levels may also affect fat cells and increase weight.[ref]
- For type 2 diabetes, researchers found that variants linked to an increase in CRP are also linked to an increased risk of diabetes.[ref]
But other studies show that genetically higher CRP levels may not always cause diseases associated with chronic inflammation.
- A study looking at the link between higher CRP levels in people with depression found that the genetic variants linked to higher CRP were likely not causal in depression. Instead, the researchers concluded that “CRP may be a compensatory response to external insults that predispose to depression and that an increase in the concentration of CRP might be adaptive.”[ref]
CRP Genotype Report
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CRP gene variants linked to increased CRP include:
Check your genetic data for rs3093058 (23andMe v4, AncestryDNA)*:
- A/A: increased CRP[ref]
- A/T: increased CRP
- T/T: typical
Members: Your genotype for rs3093058 is —.
Check your genetic data for rs3093059 (23andMe v4, v5, AncestryDNA):
- G/G: increased CRP[ref], increased risk of type 2 diabetes[ref][ref]
- A/G: increase in CRP
- A/A: typical CRP
Members: Your genotype for rs3093059 is —.
Variants linked to generally lower CRP levels:
Check your genetic data for rs1205 (23andMe v4, v5, AncestryDNA):
- C/C: typical
- C/T: lower CRP, decreased risk of heart disease, colon cancer
- T/T: lower CRP[ref][ref], decreased risk of heart disease[ref], decreased risk of lupus[ref], decreased risk of colon cancer[ref]
Members: Your genotype for rs1205 is —.
Check your genetic data for rs1800947 (23andMe v4, AncestryDNA)*:
- G/G: lower CRP,[ref] less of an increase in CRP after surgery[ref], decreased risk of heart disease[ref], a decreased risk of diabetes[ref], increased risk of colon cancer [ref]
- C/G: lower CRP, less increase in CRP after surgery, decreased risk of heart disease, diabetes
- C/C: typical CRP
Members: Your genotype for rs1800947 is —.
Check your genetic data for rs3091244 (AncestryDNA):
Members: Your genotype for rs3091244 is —.
*all risk alleles are given here in the plus orientation, but studies may refer to the risk allele on the opposite strand.
In general, lower CRP levels should indicate lower levels of chronic inflammation. You can get your doctor to order a CRP blood test for you, or you can order it yourself through an online lab company.
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Summing this all up:
Higher CRP levels increase the risk of heart disease and other chronic diseases. Your genetic variants may be playing a role in your CRP levels. The best dietary advice includes olive oil, garlic, and a Mediterranean-style diet with fresh veggies — along with red wine. Sleeping is essential, and so is moderate exercise in the sunshine. Sounds like a trip to the Greek isles is just what the doctor should order!
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Almeida, Osvaldo P., et al. “Polymorphisms of the CRP Gene Inhibit Inflammatory Response and Increase Susceptibility to Depression: The Health in Men Study.” International Journal of Epidemiology, vol. 38, no. 4, Aug. 2009, pp. 1049–59. PubMed, https://doi.org/10.1093/ije/dyp199.
Badawi, Alaa, et al. “Type 2 Diabetes Mellitus and Inflammation: Prospects for Biomarkers of Risk and Nutritional Intervention.” Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy, vol. 3, May 2010, pp. 173–86. PubMed Central, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3047967/.
Bahmani, Fereshteh, et al. “The Effects of Folate Supplementation on Inflammatory Factors and Biomarkers of Oxidative Stress in Overweight and Obese Women with Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.” Clinical Endocrinology, vol. 81, no. 4, Oct. 2014, pp. 582–87. PubMed, https://doi.org/10.1111/cen.12451.
Berk, Michael, et al. “Aspirin: A Review of Its Neurobiological Properties and Therapeutic Potential for Mental Illness.” BMC Medicine, vol. 11, Mar. 2013, p. 74. PubMed Central, https://doi.org/10.1186/1741-7015-11-74.
Chen, Xiao-Lin, et al. “Genotype CC of Rs1800947 in the C-Reactive Protein Gene May Increase Susceptibility to Colorectal Cancer: A Meta-Analysis.” Asian Pacific Journal of Cancer Prevention: APJCP, vol. 15, no. 6, 2014, pp. 2663–67. PubMed, https://doi.org/10.7314/apjcp.2014.15.6.2663.
Crawford, Dana C., et al. “Genetic Variation Is Associated with C-Reactive Protein Levels in the Third National Health and Nutrition Examination Survey.” Circulation, vol. 114, no. 23, Dec. 2006, pp. 2458–65. PubMed, https://doi.org/10.1161/CIRCULATIONAHA.106.615740.
Della Corte, Karen W., et al. “Effect of Dietary Sugar Intake on Biomarkers of Subclinical Inflammation: A Systematic Review and Meta-Analysis of Intervention Studies.” Nutrients, vol. 10, no. 5, May 2018, p. 606. PubMed Central, https://doi.org/10.3390/nu10050606.
Estruch, Ramon, et al. “Different Effects of Red Wine and Gin Consumption on Inflammatory Biomarkers of Atherosclerosis: A Prospective Randomized Crossover Trial. Effects of Wine on Inflammatory Markers.” Atherosclerosis, vol. 175, no. 1, July 2004, pp. 117–23. PubMed, https://doi.org/10.1016/j.atherosclerosis.2004.03.006.
Gao, Xiu-Ren, et al. “Efficacy of Different Doses of Aspirin in Decreasing Blood Levels of Inflammatory Markers in Patients with Cardiovascular Metabolic Syndrome.” The Journal of Pharmacy and Pharmacology, vol. 61, no. 11, Nov. 2009, pp. 1505–10. PubMed, https://doi.org/10.1211/jpp/61.11.0010.
Gawron-Skarbek, Anna, et al. “Dietary Vitamin C, E and β-Carotene Intake Does Not Significantly Affect Plasma or Salivary Antioxidant Indices and Salivary C-Reactive Protein in Older Subjects.” Nutrients, vol. 9, no. 7, July 2017, p. 729. PubMed Central, https://doi.org/10.3390/nu9070729.
Hall, Martica H., et al. “Sleep Duration during the School Week Is Associated with C-Reactive Protein Risk Groups in Healthy Adolescents.” Sleep Medicine, vol. 16, no. 1, Jan. 2015, pp. 73–78. PubMed, https://doi.org/10.1016/j.sleep.2014.10.005.
Hernández-Díaz, Yazmín, et al. “The Role of Gene Variants of the Inflammatory Markers CRP and TNF-α in Cardiovascular Heart Disease: Systematic Review and Meta-Analysis.” International Journal of Clinical and Experimental Medicine, vol. 8, no. 8, 2015, pp. 11958–84.
Huang, Yu-Chuen, et al. “C-Reactive Protein Gene Variants and Their Serum Levels in Early Adult-Onset Type 2 Diabetes Mellitus.” In Vivo (Athens, Greece), vol. 33, no. 5, Oct. 2019, pp. 1685–90. PubMed, https://doi.org/10.21873/invivo.11656.
Irwin, Michael R., et al. “Sleep Disturbance, Sleep Duration, and Inflammation: A Systematic Review and Meta-Analysis of Cohort Studies and Experimental Sleep Deprivation.” Biological Psychiatry, vol. 80, no. 1, July 2016, pp. 40–52. PubMed, https://doi.org/10.1016/j.biopsych.2015.05.014.
Jonasson, Lena, et al. “Advice to Follow a Low-Carbohydrate Diet Has a Favourable Impact on Low-Grade Inflammation in Type 2 Diabetes Compared with Advice to Follow a Low-Fat Diet.” Annals of Medicine, vol. 46, no. 3, May 2014, pp. 182–87. PubMed Central, https://doi.org/10.3109/07853890.2014.894286.
Kronish, Ian M., et al. “Aspirin Adherence, Aspirin Dosage, and C-Reactive Protein in the First Three Months after an Acute Coronary Syndrome.” The American Journal of Cardiology, vol. 106, no. 8, Oct. 2010, pp. 1090–94. PubMed Central, https://doi.org/10.1016/j.amjcard.2010.06.018.
Lim, Soo, et al. “The Relationship between Body Fat and C-Reactive Protein in Middle-Aged Korean Population.” Atherosclerosis, vol. 184, no. 1, Jan. 2006, pp. 171–77. PubMed, https://doi.org/10.1016/j.atherosclerosis.2005.04.003.
MacGregor, Alex J., et al. “Genetic Effects on Baseline Values of C-Reactive Protein and Serum Amyloid a Protein: A Comparison of Monozygotic and Dizygotic Twins.” Clinical Chemistry, vol. 50, no. 1, Jan. 2004, pp. 130–34. PubMed, https://doi.org/10.1373/clinchem.2003.028258.
Mahajan, Anubha, et al. “Common Variants in CRP and LEPR Influence High Sensitivity C-Reactive Protein Levels in North Indians.” PLoS ONE, vol. 6, no. 9, Sept. 2011, p. e24645. PubMed Central, https://doi.org/10.1371/journal.pone.0024645.
Mirhosseini, Naghmeh, et al. “Vitamin D Supplementation, Serum 25(OH)D Concentrations and Cardiovascular Disease Risk Factors: A Systematic Review and Meta-Analysis.” Frontiers in Cardiovascular Medicine, vol. 5, July 2018, p. 87. PubMed Central, https://doi.org/10.3389/fcvm.2018.00087.
Myburgh, Pieter H., et al. “CRP Genotypes Predict Increased Risk to Co-Present with Low Vitamin D and Elevated CRP in a Group of Healthy Black South African Women.” International Journal of Environmental Research and Public Health, vol. 15, no. 1, Jan. 2018, p. 111. PubMed Central, https://doi.org/10.3390/ijerph15010111.
Nimptsch, Katharina, et al. “Association of CRP Genetic Variants with Blood Concentrations of C-Reactive Protein and Colorectal Cancer Risk.” International Journal of Cancer, vol. 136, no. 5, Mar. 2015, pp. 1181–92. PubMed Central, https://doi.org/10.1002/ijc.29086.
Okada, Yukinori, et al. “Genome-Wide Association Study for C-Reactive Protein Levels Identified Pleiotropic Associations in the IL6 Locus.” Human Molecular Genetics, vol. 20, no. 6, Mar. 2011, pp. 1224–31. PubMed, https://doi.org/10.1093/hmg/ddq551.
Perry, Tjörvi E., et al. “C-Reactive Protein Gene Variants Are Associated with Postoperative C-Reactive Protein Levels after Coronary Artery Bypass Surgery.” BMC Medical Genetics, vol. 10, May 2009, p. 38. PubMed Central, https://doi.org/10.1186/1471-2350-10-38.
Potter, Gregory D. M., et al. “Longer Sleep Is Associated with Lower BMI and Favorable Metabolic Profiles in UK Adults: Findings from the National Diet and Nutrition Survey.” PLoS ONE, vol. 12, no. 7, July 2017, p. e0182195. PubMed Central, https://doi.org/10.1371/journal.pone.0182195.
Rajaie, Somayeh, et al. “Comparative Effects of Carbohydrate versus Fat Restriction on Serum Levels of Adipocytokines, Markers of Inflammation, and Endothelial Function among Women with the Metabolic Syndrome: A Randomized Cross-over Clinical Trial.” Annals of Nutrition & Metabolism, vol. 63, no. 1–2, 2013, pp. 159–67. PubMed, https://doi.org/10.1159/000354868.
Ridker, Paul M., et al. “Loci Related to Metabolic-Syndrome Pathways Including LEPR,HNF1A, IL6R, and GCKR Associate with Plasma C-Reactive Protein: The Women’s Genome Health Study.” American Journal of Human Genetics, vol. 82, no. 5, May 2008, pp. 1185–92. PubMed Central, https://doi.org/10.1016/j.ajhg.2008.03.015.
Schwingshackl, L., and G. Hoffmann. “Mediterranean Dietary Pattern, Inflammation and Endothelial Function: A Systematic Review and Meta-Analysis of Intervention Trials.” Nutrition, Metabolism, and Cardiovascular Diseases: NMCD, vol. 24, no. 9, Sept. 2014, pp. 929–39. PubMed, https://doi.org/10.1016/j.numecd.2014.03.003.
Schwingshackl, Lukas, et al. “Effects of Olive Oil on Markers of Inflammation and Endothelial Function-A Systematic Review and Meta-Analysis.” Nutrients, vol. 7, no. 9, Sept. 2015, pp. 7651–75. PubMed, https://doi.org/10.3390/nu7095356.
Shen, Jian, and Jose M. Ordovas. “Impact of Genetics and Environmental Factors on CRP Levels and Response to Therapeutic Agents.” Clinical Chemistry, vol. 55, no. 2, Feb. 2009, pp. 256–64. PubMed Central, https://doi.org/10.1373/clinchem.2008.117754.
Song, Xiaoling, et al. “A Low-Fat High-Carbohydrate Diet Reduces Plasma Total Adiponectin Concentrations Compared to a Moderate-Fat Diet with No Impact on Biomarkers of Systemic Inflammation in a Randomized Controlled Feeding Study.” European Journal of Nutrition, vol. 55, no. 1, Feb. 2016, pp. 237–46. PubMed, https://doi.org/10.1007/s00394-015-0841-1.
Stancel, Nicole, et al. “Interplay between CRP, Atherogenic LDL, and LOX-1 and Its Potential Role in the Pathogenesis of Atherosclerosis.” Clinical Chemistry, vol. 62, no. 2, Feb. 2016, pp. 320–27. PubMed, https://doi.org/10.1373/clinchem.2015.243923.
Sudhakar, Manu, et al. “C-Reactive Protein (CRP) and Leptin Receptor in Obesity: Binding of Monomeric CRP to Leptin Receptor.” Frontiers in Immunology, vol. 9, May 2018, p. 1167. PubMed Central, https://doi.org/10.3389/fimmu.2018.01167.
Sutliffe, Jay T., et al. “C-Reactive Protein Response to a Vegan Lifestyle Intervention.” Complementary Therapies in Medicine, vol. 23, no. 1, Feb. 2015, pp. 32–37. PubMed, https://doi.org/10.1016/j.ctim.2014.11.001.
Swardfager, Walter, et al. “Exercise Intervention and Inflammatory Markers in Coronary Artery Disease: A Meta-Analysis.” American Heart Journal, vol. 163, no. 4, Apr. 2012, pp. 666-676.e1-3. PubMed, https://doi.org/10.1016/j.ahj.2011.12.017.
Talikoti, Prashanth, et al. “Hyperhomocysteinemia, Insulin Resistance and High HS- CRP Levels in Prehypertension.” Journal of Clinical and Diagnostic Research: JCDR, vol. 8, no. 8, Aug. 2014, pp. CC07-09. PubMed, https://doi.org/10.7860/JCDR/2014/8945.4669.
Torres, A., et al. “Red Wine Intake but Not Other Alcoholic Beverages Increases Total Antioxidant Capacity and Improves Pro-Inflammatory Profile after an Oral Fat Diet in Healthy Volunteers.” Revista Clinica Espanola, vol. 215, no. 9, Dec. 2015, pp. 486–94. PubMed, https://doi.org/10.1016/j.rce.2015.07.002.
Wright, Kenneth P., et al. “Influence of Sleep Deprivation and Circadian Misalignment on Cortisol, Inflammatory Markers, and Cytokine Balance.” Brain, Behavior, and Immunity, vol. 47, July 2015, pp. 24–34. PubMed, https://doi.org/10.1016/j.bbi.2015.01.004.