Genetics of Grinding Your Teeth

The Genetic Polymorphisms involved in Teeth Grinding (Bruxism)
The Genetic Polymorphisms involved in Teeth Grinding (Bruxism)

It never fails to amaze me how many of our quirks and traits have a genetic basis.  A study that came out last week caught my eye. Bruxism, teeth grinding, is linked to a genetic variant.

The study, Genetic polymorphisms in the serotoninergic system are associated with circadian manifestations of Bruxism, looked into several polymorphisms in neurotransmitters such as serotonin.  For some people, SSRI’s are effective in helping  control teeth grinding.

The September 2016 study found that a variant in the HTR2A gene, which codes for a 5-HT2 serotonin receptor, is associated with bruxism.  Those with a C allele in rs2770304  were found to have twice the normal risk for bruxism.[ref]

Another study from 2012 of bruxism in a Japanese population found a different variant in HTR2A to be significant.  In that study, a G allele for rs6313 gave a 4 times greater risk for grinding your teeth in your sleep.  [ref]

Both variants are very common and have many other studies associated with them. [ref]

Check your 23andMe results for rs2770304

  • C/C: 2X increased risk of bruxism (teeth grinding)
  • C/T: increased risk of bruxism
  • T/T: wildtype/normal

 

Check your 23andMe results for rs6313

  • G/G: 4X increased risk of bruxism
  • A/G: increased risk of bruxism
  • A/A: wildtype/normal

 

So what can you do with this information? Logically, if you are grinding your teeth and have these variants, you could look into the serotonin system.   Be cautious and read up on serotonin before starting supplements that could affect your neurotransmitter levels.  Honestly, it is not clear to me whether it would be better to try to stimulate more serotonin or to try to decrease serotonin for bruxism.  Tryptophan is an amino acid that may increase serotonin, as well as 5-HTP. [ref]  So talk with your doctor and get your serotonin levels checked.



Author Information:   Debbie Moon
Debbie Moon is the founder of Genetic Lifehacks. She holds a Master of Science in Biological Sciences from Clemson University and an undergraduate degree in engineering. Debbie is a science communicator who is passionate about explaining evidence-based health information. Her goal with Genetic Lifehacks is to bridge the gap between the research hidden in scientific journals and everyone's ability to use that information. To contact Debbie, visit the contact page.