Sleep & Circadian Rhythm

Your circadian rhythm is the 24-hour internal clock which drives many important aspects of your health.  Learn about how your genes impact your circadian rhythm and how this interacts with other health topics.

Depression, Genetics, and Circadian Rhythm

For some people, circadian disruption can be chronic – and at the heart of depression or mood disorders. Genetic variants play a role in this susceptibility. Fortunately, there are solutions that may help. ​

Genes that increase the risk of insomnia and sleep disorders

A quick overview article explaining sleep related topics such as insomnia, restless leg, narcolepsy, and circadian rhythm genes. Start here and then dive deeper into the specific topics.

Circadian Rhythm: Foundation of health

The body's circadian clock regulates many different functions over the course of a 24-hour day. The genes that code for different parts of the circadian clock have a wide-ranging effect on sleep, mood, and overall health.

Melatonin: Key to Health and Longevity

More than just a sleep hormone, melatonin is at the heart of many health topics. Your genetic variants play a big role in the production of melatonin. Learn how your lifestyle and diet interact with your melatonin-related genes.

Blue Blocking Glasses To Increase Melatonin Production

An easy way to improve sleep and increase melatonin production at night is to wear blue light blocking glasses before bed. Explore the research on why this is so important, and learn about the different options available for blue-blocking glasses.

How Circadian Rhythm and Sleep Genes Impact Bipolar and Depression Risk

There is a biological link between the circadian rhythm genes and mood disorders such as depression, anxiety, and bipolar disorder. Genetic variants in the core circadian genes increase your risk for mood disorders.

Increased Slow Wave Sleep: Adenosine Deaminase

Find out how genes interact with your lifestyle in controlling the amount of deep sleep you get each night. Check out your genetic variants and hack your sleep.

Color TV has made us fat: melatonin, genetics, and light at night

The World Health Organization (WHO) categorizes light at night as a probable carcinogen. Learn why dim light at night increases your risk of breast cancer -- and what you can do to easily reduce this risk.

Using Natural Supplement to Alter Circadian Rhythm

Did you know that some supplements change the expression of your core circadian clock genes? Your core circadian rhythm genes are foundational to your health, and some supplements alter that rhythm.

Melatonin Receptor Gene: Alzheimer's risk and night shift exhaustion

Shift work and ‘social jetlag’ are linked to an increased risk for several chronic diseases. A genetic variant in the MTNR1A gene impacts melatonin receptors in the brain.

Do you wake up at 4am?

Seeing 3:30 or 4:00 on your clock each morning? There could be a physiological reason for this. Learn about the genetic variants linked to early waking insomnia and the connection to depression.

Restless Leg & PLMD

Many know the frustration of disrupted sleep due to RLS and periodic limb movement disorder (PLMD). Genes play a role in your risk for these disorders, and there are specific research-based solutions to try.