Diabetes is usually blamed on eating the wrong foods, but your genes play a big role in your susceptibility to the disease.
The TCF7L2 (transcription factor 7-like 2) gene codes for a protein that activates many genes involved in type 2 diabetes, including glucagon-like peptide 1 GLP1. Genetic variants are associated with a decreased or impaired beta-cell function. It is one of the best-studied genes with regard to diabetes risk. [ref][ref]
- T/T: 2-fold increased risk of diabetes, decreased beta-cell function[ref][ref]
- C/T: increased risk of diabetes
- C/C: normal
Members: Your genotype for rs7903146 is —.
Check your genetic data for rs12255372 (23andMe v4, v5; AncestryDNA):
Members: Your genotype for rs12255372 is —.
Want to learn more about genetics and diabetes risk factors? Check out this article!
*SNP stands for Single Nucleotide Polymorphism, which is when one of the nucleotide bases (the A, C, G, or Ts) is replaced by a different nucleotide base in a gene.
Want more quick bits about your genes? Read through all the Snips about SNPs.