Snips about SNPs: Diabetes and TCF7L2

Diabetes is usually blamed on eating the wrong foods, but your genes play a big role in your susceptibility to the disease.

The TCF7L2 (transcription factor 7-like 2) gene codes for a protein that activates many genes involved in type 2 diabetes,  including glucagon-like peptide 1 GLP1. Genetic variants are associated with a decreased or impaired beta-cell function. It is one of the best-studied genes with regard to diabetes risk. [ref][ref]

Check your genetic data for rs7903146 (23andMe v4, v5; AncestryDNA):

  • T/T: 2-fold increased risk of diabetes, decreased beta-cell function[ref][ref]
  • C/T: increased risk of diabetes
  • C/C: normal

Check your genetic data for  rs12255372 (23andMe v4, v5; AncestryDNA):

  • T/T: increased risk of diabetes[ref][ref]
  • G/T: increased risk of diabetes
  • G/G: normal

Want to learn more about genetics and diabetes risk factors? Check out this article!

 

*SNP stands for Single Nucleotide Polymorphism, which is when one of the nucleotide bases (the A, C, G, or Ts) is replaced by a different nucleotide base in a gene. 

Want more quick bits about your genes? Read through all the Snips about SNPs



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