Snips about SNPs: Diabetes and TCF7L2

Diabetes is usually blamed on eating the wrong foods, but your genes play a big role in your susceptibility to the disease.

The TCF7L2 (transcription factor 7-like 2) gene codes for a protein that activates many genes involved in type 2 diabetes,  including glucagon-like peptide 1 GLP1. Genetic variants are associated with a decreased or impaired beta-cell function. It is one of the best-studied genes with regard to diabetes risk. [ref][ref]

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Check your genetic data for rs7903146 (23andMe v4, v5; AncestryDNA):

  • T/T: 2-fold increased risk of diabetes, decreased beta-cell function[ref][ref]
  • C/T: increased risk of diabetes
  • C/C: normal

Members: Your genotype for rs7903146 is .

Check your genetic data for  rs12255372 (23andMe v4, v5; AncestryDNA):

  • T/T: increased risk of diabetes[ref][ref]
  • G/T: increased risk of diabetes
  • G/G: normal

Members: Your genotype for rs12255372 is .

Want to learn more about genetics and diabetes risk factors? Check out this article!

 

*SNP stands for Single Nucleotide Polymorphism, which is when one of the nucleotide bases (the A, C, G, or Ts) is replaced by a different nucleotide base in a gene. 

Want more quick bits about your genes? Read through all the Snips about SNPs



Author Information:   Debbie Moon
Debbie Moon is the founder of Genetic Lifehacks. She holds a Master of Science in Biological Sciences from Clemson University. Debbie is a science communicator who is passionate about explaining evidence-based health information. Her goal with Genetic Lifehacks is to bridge the gap between scientific research and the lay person's ability to utilize that information. To contact Debbie, visit the contact page.