Snips about SNPs: Opioid Receptor

Your body’s reaction to opiates, such as oxycodone or hydrocodone, depends on the opioid receptor.  Genetic variants in OPRM1 (opioid receptor, mu 1) change your response to opioids. This can mean more pain, which leads to increased dosages… And this can lead to a greater risk of opioid dependence.

Check your genetic data for rs1799971 (23andMe v4, v5; AncestryDNA)

  • A/A: Normal
  • A/G: reduced opioid receptors
  • G/G: reduced opioid receptors, more pain, decreased response to opioids

Learn more about your opioid receptor variants and how to know if you are at an increased risk of opioid dependence.

 

*SNP stands for Single Nucleotide Polymorphism, which is when one of the nucleotide bases (the A, C, G, or Ts) is replaced by a different nucleotide base in a gene. 

Want more quick bits about your genes? Read through all the Snips about SNPs



Author Information:   Debbie Moon
Debbie Moon is the founder of Genetic Lifehacks. She holds a Master of Science in Biological Sciences from Clemson University. Debbie is a science communicator who is passionate about explaining evidence-based health information. Her goal with Genetic Lifehacks is to bridge the gap between scientific research and the lay person's ability to utilize that information. To contact Debbie, visit the contact page.