Your body’s reaction to opiates, such as oxycodone or hydrocodone, depends on the opioid receptor. Genetic variants in OPRM1 (opioid receptor, mu 1) change your response to opioids. This can mean more pain, which leads to increased dosages… And this can lead to a greater risk of opioid dependence.
Check your genetic data for rs1799971 (23andMe v4, v5; AncestryDNA)
- A/A: typical
- A/G: reduced opioid receptors
- G/G: reduced opioid receptors, more pain, decreased response to opioids
Members: Your genotype for rs1799971 is —.
Learn more about your opioid receptor variants and how to know if you are at an increased risk of opioid dependence.
*SNP stands for Single Nucleotide Polymorphism, which is when one of the nucleotide bases (the A, C, G, or Ts) is replaced by a different nucleotide base in a gene.
Want more quick bits about your genes? Read through all the Snips about SNPs.
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Mast Cell Activation Syndrome, or MCAS, is a recently recognized disease involving mast cells that misbehave in various ways. Symptoms of MCAS can include abdominal pain, nausea, itching, flushing, hives, headaches, heart palpitations, anxiety, brain fog, and anaphylaxis. Dive into the research on mast cells, genetics, and solutions.
Chronic headaches, sinus drainage, itchy hives, problems staying asleep, and heartburn — all of these symptoms can be caused by the body not breaking down histamine very well. Your genetic variants could be causing you to be more sensitive to foods high in histamine. Check your genetic data to see if this could be at the root of your symptoms.