The Nrf2 (Nuclear factor erythroid 2–related factor) signaling pathway regulates the expression of antioxidants and phase II detoxification enzymes. It is a fundamental pathway important in how well your body functions. Your genetic variants in the NFE2L2 gene impact this NRF2 pathway.
Struggling with Multiple Chemical Sensitivity (MCS)? Learn about the connection between genetics, detoxification enzymes, and the olfactory system. Discover how targeting specific genetic variants can help alleviate symptoms.
Exposure to many different man-made chemical compounds occurs every day, and our exposure to new toxicants exceeds what our ancestors experienced. Several common GST variants decrease the function of the GST enzymes.