If you have tried fasting or perhaps a ketogenic diet and felt horrible, there could be a genetic reason. You might carry a genetic mutation that causes SCADD (short-chain acyl-CoA dehydrogenase deficiency).
Intermittent fasting and ketosis have a lot of benefits, but they may not be right for you. Your genes play a role in how you feel when fasting.
Utilize our Weight Loss Topic Summary Reports with your 23andMe or AncestryDNA genetic data to see which articles may be most relevant to you. These summaries are attempting to distill the complex information down into just a few words. Please see the linked articles for details and complete references. (Member’s article)
Medium-chain acyl-CoA dehydrogenase (MCAD) deficiency is an “inborn error of metabolism” which impairs the body’s ability to break down medium-chain fatty acids for fuel. Learn more about this metabolic disorder.
PRO Members: Examples of what to look for in the metabolic health report.
Is there an easy way to compare what diet might be best based on your genotype? Research shows some interesting associations between genotype and diet interactions and weight loss.
After three years of digging into genetics and learning all that I can about my genes, I wanted to get a little personal and share a few things that have worked for me.