MTHFR: How to check your data for C677T and A1298C
Check your 23andMe or AncestryDNA data for the MTHFR C677T and A1298C variants. Learn what the scientific research shows about MTHFR.
Detoxification & Metabolism of Medications
Genetic variants about in the enzymes that break down drugs and toxins. These genetic differences are why some medications don’t work well for certain people. Our reactions to toxicants, such as pesticides, also rely on our genes.
Explanation of Phase I and Phase II Detoxification
Member’s: Check out the Detoxification Topic Summary Report for a quick overview of all your genetic variants related to how you detox or metabolize different compounds.
Arsenic detoxification and your genes
Arsenic exposure occurs via well water, in certain foods, and through breathing. This article covers the pathways the body uses to get rid of arsenic, and it includes information on genetic variants that may impair the detoxification of arsenic.
CYP2B6: Genetic variants impacting medication reactions
The CYP2B6 enzyme is part of the body’s first line of defense in detoxifying and breaking down certain and important for metabolizing several medications. Genetic variants of this enzyme can either speed up or slow down its function.
CYP2C19 – Metabolizing medications
Several popular drugs such as Prilosec, Nexium, and Plavix are metabolized by the CYP2C19 enzyme. There are important genetic variants in the CYP2C19 gene that changes how fast or slowly these drugs are broken down. Learn how these variants might affect their efficacy. (Member’s article)
Vitamin K: CYP4F2 and VKORC1 Genetic Variants
Genetic variations cause people to have higher or lower levels of vitamin K, which can affect blood clotting. Learn more about the genes that affect vitamin K and how it relates to your genetic raw data.
Detoxification Topic Summary Report
Utilize our Detoxification Topic Summary Reports with your 23andMe or AncestryDNA genetic data to see which articles may be most relevant to you. These summaries are attempting to distill the complex information down into just a few words. Please see the linked articles for details and complete references. (Member’s article)
CYP2E1 Genetic Variants: Breaking down alcohol and more
The CYP2E1 enzyme is part of the phase I detoxification system. Discover how variants might affect your alcohol metabolism and more.
GSTs: glutathione-S-transferase enzymes for detoxifying environmental toxins.
Exposure to many different man-made chemical compounds occurs every day, and our exposure to new toxicants well exceeds what our ancestors experienced. There are several common GST variants that decrease the function of the GST enzymes. (Member’s article)
CYP1A2 – Breaking down caffeine and more
The CYP1A2 gene breaks down caffeine, several major prescription drugs, and interacts with smoking. Learn how your genes influence caffeine metabolism and more. (Member’s article)
SOD1: Genetic Variants in Our Antioxidant Defense System
Our body has built-in antioxidants that fight against cellular stress. The superoxide dismutase enzyme fights against oxidative stress in your cells.
CYP2C9 Genetic Variants and Drug Metabolism
Have you ever wondered why certain medications don’t work well for you? Genetic variants can change how fast or how slow the medication is broken down in your body. Learn how the CYP2C9 variants impact quite a few prescription medications.
Detoxifying Phthalates: Genes and Diet
Phthalates are a type of chemical used as plasticizers to make plastics more pliable. There has been a lot of research on the endocrine-disrupting effects of phthalates. Your genetic variants may impact whether phthalates are a problem for you.
Nrf2 Pathway: Increasing the body’s ability to get rid of toxins
The Nrf2 (Nuclear factor erythroid 2–related factor) signaling pathway regulates the expression of antioxidants and phase II detoxification enzymes. This is a fundamental pathway that is important in how well your body functions. Your genetic variants in the NFE2L2 gene impact this NRF2 pathway.
CYP2A6: Breaking down nicotine and other medications
How many cigarettes a day a person smokes – and how hard it is for them to quit – is at least partly dependent on the CYP2A6 gene. This enzyme also metabolizes several important cancer drugs.
CYP1A1: Detoxifying Cigarette Smoke and Estrogen
This phase I detoxification gene is important in the breakdown of the hydrocarbons produced in smoke and air pollution. It also affects the metabolism of estrogen.
Tamiflu
Genetic variants impact how well the flu antiviral medication, Tamiflu, works for an individual. Learn how your genes impact this medication. (Member’s article)