Genetic variants about in the enzymes that break down drugs and toxins. These genetic differences are why some medications don’t work well for certain people. Our reactions to toxicants, such as pesticides, also rely on our genes.
Member’s: Check out the Detoxification Topic Summary Report for a quick overview of all your genetic variants related to how you detox or metabolize different compounds.
Several popular drugs such as Prilosec, Nexium, and Plavix are metabolized by the CYP2C19 enzyme. There are important genetic variants in the CYP2C19 gene that changes how fast or slowly these drugs are broken down. Learn how these variants might affect their efficacy. (Member’s article)
Genetic variations cause people to have higher or lower levels of vitamin K, which can affect blood clotting. Learn more about the genes that affect vitamin K and how it relates to your genetic raw data.
Utilize our Detoxification Topic Summary Reports with your 23andMe or AncestryDNA genetic data to see which articles may be most relevant to you. These summaries are attempting to distill the complex information down into just a few words. Please see the linked articles for details and complete references. (Member’s article)
The CYP2E1 enzyme is part of the phase I detoxification system. Discover how variants might affect your alcohol metabolism and more.
We are exposed to many different man-made chemical compounds every day, with exposure to new toxicants being much higher than what our ancestors experienced. There are several common GST variants that decrease the function of the GST enzymes. (Member’s article)
The CYP1A2 gene breaks down caffeine, several major prescription drugs, and interacts with smoking. Learn how your genes influence caffeine metabolism and more. (Member’s article)
Our body has built-in antioxidants that fight against cellular stress. The superoxide dismutase enzyme fights against oxidative stress in your cells.
Phthalates are a type of chemical used as plasticizers to make plastics more pliable. There has been a lot of research on the endocrine-disrupting effects of phthalates. Your genetic variants may impact whether phthalates are a problem for you.
The Nrf2 (Nuclear factor erythroid 2–related factor) signaling pathway regulates the expression of antioxidants and phase II detoxification enzymes. This is a fundamental pathway that is important in how well your body functions. Your genetic variants in the NFE2L2 gene impact this NRF2 pathway.
How many cigarettes a day a person smokes – and how hard it is for them to quit – is at least partly dependent on the CYP2A6 gene. This enzyme also metabolizes several important cancer drugs.
This phase I detoxification gene is important in the breakdown of the hydrocarbons produced in smoke and air pollution. It also affects the metabolism of estrogen.
Genetic variants impact how well the flu antiviral medication, Tamiflu, works for an individual. Learn how your genes impact this medication. (Member’s article)
Ever wonder why a certain medication may work great for a friend and do nothing for you? One reason could be the genes involved in transporting the medication into and out of your cells.
This article looks at the research studies on fexofenadine (Allegra) and the Multidrug Resistance Protein variants. (Member’s article)
Wondering why you don’t react the same way to alcohol as your friends do? Some people metabolize alcohol faster leaving a build-up of acetaldehyde. Learn more about why this can be a health problem for some. (Member’s article)
The UGT family of enzymes are responsible for an important part of phase II detoxification. This article explains what the UGT enzymes do in the body, how your genes impact this part of detoxification, and lifestyle factors that can increase or decrease this detox process.
The CYP2C8 gene is important in the metabolism of several chemotherapy drugs (e.g. Taxol) as well as playing a role in the metabolism of NSAIDs. Genetic variants that alter the way that this enzyme works can impact your reaction to a medication.