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The F11 Gene: What does it do?

F11 Gene Description:


The F11 gene provides instructions for making a protein called factor XI. This protein plays a role in the coagulation cascade, which is a series of chemical reactions that forms blood clots in response to injury. After an injury, clots seal off blood vessels to stop bleeding and trigger blood vessel repair.

Factor XI is made primarily by cells in the liver. The protein circulates in the bloodstream and is normally turned off (inactive) until the coagulation cascade is turned on (activated) by an injury that damages blood vessels. When factor XI is activated, it interacts with other coagulation factors, resulting in conversion of an important coagulation protein called prothrombin to its active form, thrombin. Thrombin then converts a protein called fibrinogen into fibrin, which is the material that forms blood clots.

Genetic Lifehacks articles that include F11 variants (SNPs):

7 genetic variants that increase your risk of blood clots

Mutations common in Ashkenazi Jewish populations

Checking Your Carrier Status for Rare Genetic Diseases

About the Author:
Debbie Moon is the founder of Genetic Lifehacks. Fascinated by the connections between genes, diet, and health, her goal is to help you understand how to apply genetics to your diet and lifestyle decisions. Debbie has a BS in engineering from Colorado School of Mines and an MSc in biological sciences from Clemson University. Debbie combines an engineering mindset with a biological systems approach to help you understand how genetic differences impact your optimal health.