Category «Genetics»

Review of Genos – Whole Exome Sequencing

Genos - Whole Exome Sequencing1

 Genos is a fairly new company in the direct-to-consumer genetic sequencing market.  They offer sequencing of the whole exome, instead of just the specific locations that are covered by services such as 23andMe or AncestryDNA. Moreover, they are bringing in research study partners that then will pay their clients for participating in the studies.  It is …

How to download your 23andMe data

How to download your raw data file from 23andMe

Someone asked me recently how to download their data from 23andMe.   So here is a quick tutorial if anyone else is searching for their raw data file on the 23andMe website. Why download your data? It is yours, and it may be something you need in the future.  23andMe could change their policy on …

Checking Your Carrier Status for Genetic Diseases

Carrier Status

The term “carrier status” when applied to a genetic disease usually means looking at whether or not you are heterozygous (have one copy) for a mutation that causes a Mendelian genetic disease.  Generally, these are the rare diseases that you would need two copies of the variant to have the disease. Take cystic fibrosis as …

Dyslexia – Genetic Connections

Genetics of Dyslexia

While dyslexia is known to run in families, the role of genetics in dyslexia is still being determined.  Here is a quick look at some of the genes thought to be involved in dyslexia, which affects around 10% of the population. Two of the genes (KIAA0319 and DCDC2) identified as probably playing a role in dyslexia …

Creating your own genetics “reports” for free

Create your own genetics report in Excel using your 23andMe raw data file.

Reading through some Facebook questions the other day, it hit me that most people are not keeping track of their genetic information for themselves.  There are so many recommendation for ‘reports’ that you can order for $19 or $50 or much more.  A lot of these reports just color your SNPs red or green, which …

Genetics of Grinding Your Teeth

The Genetic Polymorphisms involved in Teeth Grinding (Bruxism)

It never fails to amaze me how many of our quirks and traits have a genetic basis.  A study that came out last week caught my eye.  Bruxism (teeth grinding) is linked to a genetic polymorphism! The study, Genetic polymorphisms in the serotoninergic system are associated with circadian manifestations of Bruxism, looked into several polymorphisms in …

Mono and genetics

Ever wonder why some people get mono and others don’t?  Almost 95% of adults carry antibodies to the Epstein Barr virus that causes mono, but less than 30% of people are estimated to get mono.  [CDC.gov]   Turns out that there may be a genetic susceptibility to mono as well as environmental factors.  Twin studies, one way …

Ear wax and body odor – it’s genetic

The ABCC11 gene determines both the type of ear wax a person has and their armpit odor.   Loss of function of the ABCC11 gene is very common among East Asian populations (80-90%), but fairly rare in other populations (1 – 3% of Caucasians). There was an interesting article in Scientific American a few years ago …

PMS, Genetics, and Solutions

PMS, Genetics, Solutions

A LOT of us know the moodiness and inability to think that come with premenstrual syndrome (PMS).  It can range from simply feeling irritable and icky to being something that really interferes with our lives.  Is there something genetic that predisposes some women to PMS?  It has been shown in the past few years that there …

Genetics of Celiac Disease

Edited: This was originally posted as two entries, now combined to have all the information in one spot.   One of my main reasons for getting 23andMe testing done was to figure out if I could possibly have celiac disease.  I went gluten-free about five years ago and have felt so much better that I …