This gene codes for the adenosine receptor protein, which, among other things, plays a role in the brain in regulating dopamine and glutamine release. Caffeine partially blocks the receptor. Both of the variants listed below are very common.
T/T: no increase in anxiety from caffeine (avg. amount)
C/T: no increase in anxiety from caffeine
C/C: high caffeine dose more likely to make you anxious[ref][ref]
Interesting studies on ADORA2A:
While the two variants above are tied to increased anxiety with caffeine, they are also found to correspond with increased anxiety in general (not linked to caffeine).
Have dry eyes? These two ADORA2 variants lead to slightly increased tear volume with caffeine consumption.
A study found that those who were more susceptible to anxiety from caffeine were, also likely to have a higher habitual caffeine intake. Those drinking more coffee tended to build up a tolerance to the anxiety-inducing effects regardless of genotype.
Diet and Lifestyle: Looking for a way to pep up your morning coffee? Here are a couple of options:
Include Bulletproof Brain Octane Oil in your coffee.
Add Lion’s Mane and Chaga mushroom extracts with cognitive benefits (my new favorite!).
More of a tea person? Black teas have the highest caffeine content, ranging from 25 – 50 mg per 8oz cup, while white tea has a much lower caffeine content.
Coffee consumption studies: If your beverage of choice in the morning is coffee, here are some studies on the effects:
A meta-analysis study showed that coffee consumption (4 cups a day) decreased the risk of breast cancer in post-menopausal women by 10%. Another study indicates that the reduction in risk (found to be closer to 30% for those drinking 5 cups a day) may be due to something else in coffee other than caffeine because other caffeinated drinks did not give the same result.
For those with the BRCA1 mutation, one study found that coffee consumption before age 35 for those with the C-allele reduced their risk of breast cancer by 64%.[ref]
Another meta-analysis found that high coffee consumption may lead to a decreased risk of pancreatic cancer.
Author Information: Debbie Moon
Debbie Moon is the founder of Genetic Lifehacks. She holds a Master of Science in Biological Sciences from Clemson University. Debbie is a science communicator who is passionate about explaining evidence-based health information. Her goal with Genetic Lifehacks is to bridge the gap between scientific research and the lay person's ability to utilize that information. To contact Debbie, visit the contact page.
Everthing presented on this site is for informational and educational purposes only. Read the research, decide for yourself, talk with your doctor.
Genetic variants only give you part of the picture -- your lifestyle, diet, gut microbes, and environment all interact with your genes.
Research on genetics is fairly new and ever changing. Articles all contain links to references, and you are encouraged to read through the research.
* Genetic variants are all listed in the plus or forward orientation to match with 23andMe or AncestryDNA data.
Everything on this website is for educational purposes only and not to be used as medical advice. Please talk to your doctor for medical adivice.