Whether you start your morning with a cup of coffee or a cup of tea, caffeine remains the most popular ‘drug’ of choice for a large percentage of the population.
Caffeine wakes us up by blocking the adenosine receptor. Caffeine also acts as a central nervous system stimulant, increasing reaction time.
Genetics determine how quickly your body processes and eliminates caffeine and whether it is likely to make you jittery or anxious.
This gene codes for the enzyme that metabolizes, or breaks down, caffeine in the body.
If you are a slower metabolizer, you will feel the effects of caffeine for a longer time.
If you are a fast metabolizer, you will break down and get rid of caffeine more quickly from your system.
Check your genetic data for rs762551 (23andMe v.4, v.5; AncestryDNA):
ADORA2A Gene (Adenosine 2A receptor):
This gene codes for the adenosine receptor protein, which, among other things, plays a role in the brain in regulating dopamine and glutamine release. Caffeine partially blocks the receptor. Both of the variants listed below are very common.
Check your genetic data for rs5751876 (23andMe v.4, v.5)
Check your genetic data for rs2298383 (23andme v.5 only):
Interesting studies on ADORA2A:
Diet and Lifestyle:
Looking for a way to pep up your morning coffee? Here are a couple of options:
Include Bulletproof Brain Octane Oil in your coffee:
Add Lion’s Mane and Chaga mushroom extracts with cognitive benefits (my new favorite!): More of a tea person? Black teas have the highest caffeine content, ranging from 25 – 50 mg per 8oz cup, while white tea has a much lower caffeine content.
Coffee consumption studies:
If your beverage of choice in the morning is coffee, here are some studies on the effects:
More to read: