Factor V Leiden

Say you are chopping up peppers for your morning omelet and slip with the knife. Ouch! While cutting your finger seems to produce a huge amount of blood compared to the size of the wound, the actions going on behind the scenes to stop that blood flow are pretty darn cool.

When you get a cut or wound, a cascade of events takes place in the body.

How Does Blood Clot:

Blood vessels are made of endothelial cells (the same types of cells that make up skin) and those cells are tightly joined together. When a blood vessel gets damaged, it is imperative that the damage gets fixed quickly to prevent you from bleeding to death. The platelets in your blood clump together to form a clot blocking the damaged part of the blood vessel. Platelets flow through your blood vessels all the time, without clumping together, so there must be a way clumping is activated when a clot is needed.

Additionally, collagen, which is located on the outside of the blood vessels, interacts with the platelets causing them to clump together.  Another protein, fibrinogen, also comes in to bolster the clot and make it strong by being activated into fibrin. A cascade of events takes place here quickly to activate the fibrinogen. Thrombin is the main activator and turns fibrinogen into fibrin. Within this cascade, many ‘factors’ are present and integral to the process, like factor V and factor VIII, but for our purposes here, we will focus on factor V.

Factor V, coded for by the F5 gene, is a coagulation protein mainly synthesized in the liver.  It is activated in clotting by thrombin and can bind to activated platelets. Just as there is a cascade of events to quickly cause a blood clot to form, there are other molecules involved, such as protein C, in turning off the clotting when it is no longer needed. [ref]

Mutations (rare) that cause a deficiency in factor V cause mild forms of hemophilia, or an inability to clot well. More severe forms of hemophilia are caused by a mutation in other factor genes (e.g. factor IX mutation caused the type of hemophilia in European royal families).

Factor V variant:

Conversely, the opposite problem occurs with the factor V Leiden variant. A change in the gene causes a more active version to resist the shutoff signal from activated protein C and stay active, thus increasing thrombin and prolonging the clotting action. The clot can become larger than it should be, blocking blood flow if it is in the wrong place.

Factor V Leiden has been linked in many studies to an increased risk of deep vein thrombosis and pulmonary embolism. A meta-analysis combined data from 31 studies estimates that the increase in the risk of thrombosis for people carrying one copy of the variant was 4-fold and the increase for those carrying two copies was 11-fold. [ref][ref][ref][ref]

This does not mean that everyone who carries the factor V Leiden will have a deep vein thrombosis (DVT) or pulmonary embolism — but they are at a statistically higher risk. The CDC estimates the per year incidence of DVT is 1 to 2/1000 people. [ref] An 11-fold increase in risk for someone who is homozygous for the variant would then indicate a 1 to 2% risk of DVT in a given year.

Factor V Leiden has also been linked in studies to an increased risk of miscarriage. [ref][ref] The risk may be more for women who are homozygous for the variant. One study found that the rate of live births for non-carriers of factor V Leiden was 85%. Women who carry one copy of the variant had an 84% live birth rate, and women who carried two copies of the variant had an 80% live birth rate.[ref]

A good source of information on thrombosis and clotting disorders is Clot Connect, from the University of North Carolina.

The factor V Leiden variant is found in about 5-8% of people of European descent. Researchers have several theories of why such a deleterious mutation has been passed down at a higher rate. Interestingly enough, one advantage of clotting more readily would be for women in childbirth, which historically included high rates of hemorrhaging. In times of war, it would also be an advantage to clot a little better when wounded. And finally, there is a statistically higher sperm count found in men who are carriers of the factor V Leiden variant, so the mutation would have been slightly more likely to be passed on to more offspring.[ref][ref][ref]

 


A genetic variant that affects factor V Leiden:

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Check your genetic data for rs6025 (23andMe v4, v5; AncestryDNA):

  • C/C: typical
  • C/T: one copy of factor V Leiden
  • T/T: two copies of factor V Leiden

Members: Your genotype for rs6025 is .


Lifehacks:

Talk to Your Doctor:

This is one of those ‘talk to your doctor’ types of situations. Your doctor should know, based on all of your medical history, whether you should take preventative medications for thrombosis. Also keep in mind that 23andMe data is not guaranteed to be 100% accurate, so a clinical test should be done to verify the results before taking medical action.

The question that may come to mind here is whether talking with your doctor about carrying the genetic variant for factor V Leiden will raise your insurance rates.  In the US, your health insurance company cannot raise your rates due to the results of a genetic test. That is not true, though, for life insurance companies, who may (or may not) make their rate dependent on genetic information in your electronic health records. Here is more information on this topic from a genetic counselor: http://patientblog.clotconnect.org/2011/08/10/thrombophilia-and-insurance/

Suggestions to decrease blood clot risk:

Activities:
Events that increase the risk for someone to have a blood clot include flying on airplanes and being dehydrated.  So drink lots of water and avoid alcohol and caffeine while flying

Aspirin:
There have been clinical trials on aspirin (100 mg/day) for preventing blood clots. The overall results show that there might be a minor benefit for women who carry the factor V Leiden variant — but again, talk with your doctor and see if this is right for you. [ref]

A 2006 study concluded that there is no reason for aspirin before flying on an airplane.[ref]

Cigarettes:
Smoking increases your risk for blood clots, and this would be magnified in someone with factor V Leiden.[ref]

The risk of blood clots for someone who is homozygous for the factor V Leiden variant, who smokes, is overweight, and is over age 60 is quite high. The absolute 10-year risk in this case for venous thromboembolism is 51%. [ref]


Related Genes and Topics:



Author Information:   Debbie Moon
Debbie Moon is the founder of Genetic Lifehacks. She holds a Master of Science in Biological Sciences from Clemson University and an undergraduate degree in engineering. Debbie is a science communicator who is passionate about explaining evidence-based health information. Her goal with Genetic Lifehacks is to bridge the gap between the research hidden in scientific journals and everyone's ability to use that information. To contact Debbie, visit the contact page.