Our ancient ancestors lived much differently than we do today. They were hunter-gatherers, living off of fish, meat, and plant foods that they gathered. A huge shift took place when those hunter-gatherers began farming, growing grains and storing them so that there would be food available all year.
The ‘ancestral foods’ movement – whether Paleo, low carb, or other diet tribes that eschew grains – likes to paint the picture that we should eat like our ancestors, the hunter-gatherers. It is a narrative that resonates with people. “Why did we start eating all the grains and carbs? Grains are full of carbs that make us fat and lazy…”
This article hits the high points of a new paper explaining a genetic change took place around the time that agriculture began to take off. The genetic variant influences our ability to utilize more carbohydrates, such as through eating grains. Yes – included below is the genetic variant to check in your 23andMe data to see if you carry the ‘hunter-gather variant’ or the ‘farmer variant’.
Hunter-Gatherer vs. Farmer Gene
A research paper published in June 2019 casts an interesting light on how the human genome changed to deal with an increased intake of carbohydrates around the time that many populations shifted to an agriculture-based society. The whole paper is available (open access!) if you want to go read it.
To understand the change that took place, let’s dig into the science of how insulin regulates blood glucose levels.
Background on glucose transport:
When you eat something with carbohydrates, the carbs are broken down in the intestines and absorbed as smaller sugar molecules. While there are multiple types of sugar (fructose, lactose, glucose, galactose), I’m going to focus on glucose, which is the simple sugar used by cells for energy.
After eating foods containing carbohydrates, glucose absorption occurs in the intestine. Additionally, the liver makes glucose when it isn’t readily available from foods. Thus, we have a fairly constant supply of glucose on hand, available to all cells, when carbs have been recently consumed. (Low-carb diets and ketosis change this.)
Glucose gets absorbed into the bloodstream and circulates throughout the body. It can be taken into a cell and used in making ATP, which is the molecule the cells use for energy.
Glucose only enters cells through a tightly regulated transport system. Similarly, the body regulates the amount of glucose in the bloodstream. Consistently high levels of blood glucose lead to type 2 diabetes and the subsequent chronic disease consequences. So, it is important to keep the blood glucose levels within a certain range. The body regulates glucose by controlling the amount absorbed by the muscle and fat cells. If blood glucose is too high, the body stores more in muscle and fat.
For glucose to enter the cell, it needs a receptor protein to be available on the cell surface. Different types of tissue have different glucose receptors. For skeletal muscles and fat cells, this receptor is GLUT4.
When the GLUT4 receptor doesn’t need to take in glucose, it can be found residing in the cytosol inside the cell. Alternatively, when the GLUT4 receptor is at the surface of the cell, it can bring in glucose.
Insulin is the signal that brings GLUT4 to the surface of the cell to transport glucose. When blood glucose levels rise, the pancreas releases insulin. The insulin then causes the GLUT4 receptors to come to the cell membrane and transport the glucose into the cell.
Moving GLUT4 into the cell:
The GLUT4 receptor moves back into the cell and remains held there by a clathrin-coated vesicle called CHC22. This is where the hunter-gatherer vs. farmer genetic variant comes into play. The CHC22 protein is coded for by the CLTC1 gene, and researchers found that there is a variant of this gene that causes it to be less effective at holding GLUT4 inside the cell. This, in turn, causes the cells to have more GLUT4 on the cell surface, lowering blood glucose levels when eating more carbohydrates.
Hunter-gatherer vs. Neolithic farmers:
The researchers found that this variant in the CLTC1 gene first became prevalent in the genomes of ancient Neolithic farmers. The ancestral version of the gene, exclusively found in the genomes of Neanderthals and Holocene-era hunter-gatherers, isn’t as good at dealing with a high carbohydrate diet.
First, let’s take a minute to acknowledge a cool factor! A bunch of fully sequenced genomes from Neanderthals and ancient hunter-gatherer populations now exist. The researchers who wrote this paper on the CTLC1 gene were also able to look at the genomes of other animal species, tracing the gene and the changes through everything from fish to mice to chimpanzees.
Prevalence of the genetic variant today:
Notably, in human populations today, the CLTC1 variant is fairly well divided up with almost equal portions of the population carrying either the ancestral hunter-gatherer variant or the newer variant that is better adapted for eating carbohydrates.
This makes sense when you think about it – as a population, we are resilient and able to eat a variety of different diets, which often change from generation to generation depending on the availability of foods. You may have Irish ancestors who thrived on potatoes as well as Norwegian ancestors who survived on fishing. There are dozens of examples today of population groups that survived on specific diets, such as the Inuits in Alaska or the Hadza in Africa.
Check your genetic data for the hunter-gatherer vs. farmer variant:
Check your genetic data for rs1061325 (23andMe v4, v5):
- C/C: two copies of the ‘farmer’ allele, possibly better able to handle carbs
- C/T: one copy of the farmer allele and one copy of the hunter-gather allele
- T/T: two copies of the hunter-gatherer allele, possibly less adapted to high carbohydrates
Members: Your genotype for rs1061325 is —.
What can you do with this information?
While it is fascinating information, I want to caution that this is just one study, looking at the evolution of a genetic variant. Researchers still need to investigate whether the CLTC1 genetic variant has a big impact on glucose regulation in humans today. None of the prior large genome-wide studies have indicated that this gene is important in the risk for diabetes, which you would expect if the variant played a large role in the inability to handle a high carb diet.
While this is a really cool study, I think a lot more research needs to be done on this gene and genetic variant before applying the information to make dietary changes.
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