Oxytocin Levels: Genetics of the Love Hormone

Oxytocin is a hormone produced in the hypothalamus region of the brain.  Often called the “love hormone”, it is involved in parents bonding with their baby, recognition of other’s emotions, and overall social involvement.

What is Oxytocin?

Oxytocin is produced at a high level during childbirth, relaxing the cervix and causing contractions. Interestingly, it also crosses the placenta and acts on the neurotransmitters of the baby, preparing him or her for birth. It is also involved in breastfeeding and milk let down.

Outside of the physiological roles in childbirth, oxytocin acts as in the brain as a neuropeptide and influences social activity and group bonding.

How is oxytocin made?

Oxytocin is synthesized in a series of steps, starting with the OXT gene, which creates the inactive precursor needed for the hormone. The final activation is catalyzed by the PAM enzyme, which needs vitamin C as a co-factor.

In general, genetic variants that decrease oxytocin production have been found in psychological studies to decrease a person’s social sensitivity and empathy.  Before all of you with high oxytocin levels start thinking “oh no, poor thing” (ha!), there are some positive outcomes from not being as emotional. Genetic variants linked to lower empathy and less socially sensitive were found to be more resilient in the face of childhood maltreatment.[study][study]

A mother’s oxytocin levels also play a role in a baby’s response to early life stress, both before and after the baby is born. Yes, you can blame your mom if your brain isn’t wired the same way as others. [study]

Culture plays a role in how the oxytocin gene variants are interpreted.  For example, one study found that while Americans with a genetic variant were likely to seek out emotional support, Koreans were not.

Genetic variants in the OXT gene:
There are a couple of common genetic variants that influence a person’s level of oxytocin.

Check your genetic data for rs53576 (23andMe v4, v5; AncestryDNA):

  • G/G: More oxytocin, empathetic, optimistic, seeks and gives emotional support [study][study]
  • A/G: Not as empathetic, not generally as social with groups
  • A/A: Not as empathetic, not generally as social with groups [study]

Check your genetic data for rs1042778 (23andMe v4; AncestryDNA)

  • G/G: More oxytocin, more socially empathetic, less inhibited, possibly more creative[study]
  • G/T: Less empathetic, more socially inhibited [study], possibly more creative
  • T/T: Less emotional and social[study], higher levels of antisocial behavior in men[study]



Looking to change your oxytocin levels? Here are several ways that research shows to alter your levels.

Petting a dog increases both the human and dog oxytocin levels.[study]  Another study showed that a dog gazing at you could increase oxytocin levels.  Gives new meaning to “puppy-dog eyes”.

Your gut microbiome can affect your oxytocin levels. Mouse studies show that maternal microbiome and diet play a role in their oxytocin levels and effects their offspring.[study] A study also showed the effects of antibiotics decreasing oxytocin levels. Lactobacillus reuteri was shown to increase oxytocin and speed wound healing.

Hormonal contraceptives in women influence oxytocin levels and partner preferences. Here is an interesting study on it.

Vitamin C.  If you are less apt to be social, perhaps some vitamin C before going to a group function might help to increase oxytocin.[study][study] Or increase your sex life.[study]

Creativity has been linked to oxytocin levels. A double-blind, placebo-controlled study found that intranasal oxytocin “reduced analytical reasoning, and increased holistic processing, divergent thinking and creative performance.”

Loving-kindness meditation may increase your oxytocin levels.[study]

Listening to music may increase oxytocin levels.[study]

Not a recommendation here…  MDMA (Ecstasy) increases oxytocin levels.[study]

More to read:

I’ll leave you with puppies gazing at you….

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One Comment on “Oxytocin Levels: Genetics of the Love Hormone

  1. Great article!

    I couldn’t help but notice you linked at the end to that classic article about increasing oxytocin by Be Brain Fit.

    I also love that resource.

    In fact, it inspired me to create a more thorough and up-to-date version. Here’s the link in case you want to check it out: https://www.optimallivingdynamics.com/blog/25-effective-ways-to-increase-oxytocin-levels-in-the-brain

    It might be worth a mention in your article :-)

    Either way, keep up the awesome work!


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