Adiponectin, discovered in the 1990s, is a hormone secreted by adipose (fat) tissue. As an anti-inflammatory protein, it protects against the effects of low-grade inflammation associated with obesity.
Although production occurs in adipose tissue, those with more fat tissue usually have lower adiponectin levels. Lower adiponectin levels (and thus high inflammation) have links to chronic issues associated with obesity.[ref]
Additionally, low levels of adiponectin have links to insulin resistance, diabetes, heart disease, and cancer.[ref]
ADIPOQ gene: responsible for adiponectin creation
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Some polymorphisms increase adiponectin levels, leading to a lower risk of insulin resistance, and some polymorphisms decrease adiponectin levels which leads to a higher risk of insulin resistance and diabetes. Diet and ethnicity also seem to play a role in how these polymorphisms affect a person.
Check your genetic data for rs17300539 (23andMe v4, v5):
- A/A: lower weight, BMI; and higher adiponectin levels; benefits from a monounsaturated fat diet and MUFA > 13% cuts risk of obesity in half[ref][ref]
- A/G: somewhat higher adiponectin levels
- G/G: most common genotype
Members: Your genotype for rs17300539 is —.
Check your genetic data for rs1501299 (23andMe v4, v5):
- T/T: higher adiponectin levels in some populations[ref] and lower adiponectin levels in other populations[ref][ref] This may be related to the amount of fiber in the diet (see below), increased adiponectin signaling, protective against heart disease.[ref]
- C/T: higher adiponectin in some population (with low fiber diet)
- G/G: lower adiponectin levels in most populations, higher adiponectin levels compared to T carriers when eating a low fiber diet[ref], increased risk of endometrial cancer[ref] breast cancer, which is associated with low adiponectin signaling[ref]
Members: Your genotype for rs1501299 is —.
Check your genetic data for rs266729 (23andMe v4, v5):
- C/C: lower adiponectin levels[ref][ref][ref] (most common genotype)
- C/G: typical levels
- G/G: Caucasian men with G/G (23andMe orientation, more common alleles), switching from a saturated fat-rich diet to either a carbohydrate-rich diet or a monounsaturated fat-rich diet caused plasma glucose concentrations to decrease.[ref]
Members: Your genotype for rs266729 is —.
Check your genetic data for rs2241766 (23andMe v4, v5):
- G/G: higher risk of Type 2 Diabetes in Asian populations[ref]
- G/T: higher risk of Type 2 Diabetes in Asian populations
- T/T: typical
Members: Your genotype for rs2241766 is —.
What works and doesn’t work:
Increasing adiponectin levels seems like a good idea since low levels of adiponectin are a risk factor for heart disease. But it isn’t absolutely clear that manipulating adiponectin levels will cause weight loss.
- Orlistat (Alli) increases adiponectin levels[ref]
- Both blueberry juice and mulberry juice increased adiponectin levels (in mice)[ref]
- In mice, Platycodon grandiflorus root extract (Korean medicinal food) improved insulin sensitivity to activation of PPARG which upregulates adiponectin[ref]
Here are a few tested things not found not to increase adiponectin levels:
- Fish oil doesn’t seem to have much effect on adiponectin levels.
- Green tea extract doesn’t affect adiponectin levels[ref]
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Debbie Moon is the founder of Genetic Lifehacks. Fascinated by the connections between genes, diet, and health, her goal is to help you understand how to apply genetics to your diet and lifestyle decisions. Debbie has a BS in engineering and also an MSc in biological sciences from Clemson University. Debbie combines an engineering mindset with a biological systems approach to help you understand how genetic differences impact your optimal health.