How our genes shape our gut microbiome and our weight

Several studies have come out recently showing that those who are overweight have a different gut microbiome composition than those who are lean.  There have also been interesting mouse studies showing that transplanting feces from obese mice into lean mice causes lean mice to…

Emulsifiers in Processed Foods: Your genes and your microbiome

Recently, I listened to an interview (from 2015) of a scientist who did a study on emulsifiers and found that they can lead to low-grade inflammation in the gut, especially in mice with certain immune system genes knocked out. I find the interaction between our…

Adiponectin levels, food choices, and genetics

Adiponectin, a hormone discovered in the 1990’s, is secreted by adipose (fat) tissue.  It is an anti-inflammatory protein, protective against the effects of low-grade inflammation that are associated with obesity. Although it is made in adipose tissue, those who have more fat tissue usually have lower…

Weight Loss Genetics – DHEA

Dehydroepiandrosterone (DHEA) is one of our body’s most abundantly produced steroid hormones. It is secreted by the adrenal glands, gonads, and in the brain. DHEA acts as both a precursor hormone to testosterone and DHT and as a neurotransmitter. Like other hormones, we tend…

Weight Loss Genetics – PLIN1

The perilipin 1 gene codes for the protein that covers lipid droplets in fat cells.  This coating protects the lipid droplets from the enzymes that break down fats for use as energy in the body.  Increased perilipin is associated with obesity.  Mice bred to be…

PPARG: A genetic variant that can protect against obesity and type-2 diabetes, but only if you eat the right diet.

The PPARG (peroxisome proliferator-activated receptor-gamma) gene has been associated with obesity, metabolic syndrome, and risk for type-2 diabetes. This gene is involved in the regulation of fatty acid storage and in glucose metabolism. What is PPARG? The PPARG gene codes for a protein that…

FTO: The ‘fatso’ gene & weight loss options

Research shows that about 60% of obesity susceptibility is due to genetic differences, and the FTO gene is one of the key genes that has been consistently shown to impact weight. [ref] The FTO gene, or ‘fatso gene’, got its nickname because of its…

UCP2 Gene: Weight Loss Lifehacks

Turning up the heat on your metabolism is the job of UCP2. The UCP2 gene codes for an uncoupling protein that works in the mitochondria (energy powerhouse) of our cells, producing heat through the uncoupling of the protons. It is found in a variety…

Weight Loss Genetics – MC4R Revisited

I was catching up on podcasts this weekend and listened to a fascinating one by Dr. Rhonda Patrick.  She does the Found My Fitness podcast and had recently interviewed Dr. Panda.  The interview was on circadian rhythms and time restricted feeding.  In a nutshell, time…

Weight loss genetics – GNB3 C825T

There are lots of different genetic variants that add a little bit to your risk of being overweight. These genetic variants, of course, combine with environmental factors such as food choices, sleep, and toxin exposure. So it isn’t as simple as having a ‘fat…