Obesity risk – GNB3 C825T

There are lots of different genetic variants that add a little bit to your risk of being overweight. These genetic variants, of course, combine with environmental factors such as food choices, sleep, and toxin exposure. This article looks into a well-studied variant that can increase the risk of obesity, hypertension, and cardiovascular events and focuses on some applicable lifehacks that can help reduce those risks.

Is obesity a genetic problem?

GNB3 gene codes for a protein that transfers a signal from the cell's surface into the cell, thus causing a response. Therefore, a genetic variant in this gene that alters its function can cause a variety of responses within different cells. One relatively well-studied GNB3 variant, rs5443 or C825T, confers a 2x to 3x risk of obesity.[ref] This one genetic change is found in varying percentages in different population groups. While the minor allele is T for most populations, it is the most common allele for those of African descent.  For example, about 10% of Caucasians carry two copies of the variant (T/T), while Africans have approximately 80% of most population groups carrying the variant allele.

GNB3 Genetic Variant:

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