Heart Health

Your genetic data can help you find out more about your susceptibility to heart disease. Whether you have a family history of heart problems or just want to optimize your health, your genes can give you insight into the best ways to prevent heart-related problems.

Start here:

  1. Check to see if you carry the Lp(a) variant that is linked to ‘widow maker’ heart attacks. 
  2. See how your genes impact cholesterol levels.
  3. Are you at risk for blood clots? 

Recent articles in the Heart Disease category:


  • Will Aspirin Prevent Heart Disease?
    While large population studies show the benefits of aspirin, research shows that these heart-health benefits are dependent on your genes. Find out more and check your genetic raw data.
  • Nitric Oxide Synthase: Heart health, blood pressure, and aging
    Nitric Oxide Synthase is an important signaling molecule in the endothelium of our blood vessels. It has roles in the regulation of blood pressure, cardiovascular disease, brain health, and more. Genetic variants in nitric oxide genes are important for a healthy heart. Find out how your genes could play a part in the interactions with cardiovascular disease risk and blood pressure.
  • Elevated Fibrinogen: Risk factor for blood clots
    Fibrinogen is a protein that is essential for creating blood clots when you get a wound. But higher levels of fibrinogen are a major risk factor for heart disease and DVT. Learn how your genes impact your fibrinogen level.
  • 7 genetic variants that increase your risk of blood clots
    Some people are unique in their ability to form clots more easily. This article covers six different genes and the seven genetic variants that increase the risk of blood clots. It is a timely topic because blood clots seem to be a serious complication for people with COVID-19.
  • The genetics of high triglycerides
    High triglycerides are linked with an increased risk of cardiovascular disease. Both genetics and diet combine to elevate triglyceride levels. Learn how your genes interact with what you eat to lower your triglycerides.
  • Building Up Iron: Check your genetic data for hemochromatosis mutations
    A couple of common mutations can cause you to build up iron, leading to iron overload or hemochromatosis. This is one genetic disease where knowledge is really powerful – you can completely prevent hemochromatosis through blood donations.
  • Heart Health Topic Summary
    Utilize our Heart Health Topic Summary Reports with your 23andMe or AncestryDNA genetic data to see which articles may be most relevant to you. These summaries are attempting to distill the complex information down into just a few words. Please see the linked articles for details and complete references. (Member’s article)
  • LDL Cholesterol Genes
    Your genes combine with your diet to influence your LDL cholesterol level. Learn more about why LDL cholesterol levels may matter in heart disease and find out how your genes are important here.
  • Plant Sterols for Lowering Cholesterol? Depends on Your Genes
    Plant sterols are known as a ‘heart-healthy’ way to lower cholesterol. But, it turns out that they may only lower cholesterol only in people with certain genetic variants. Check your genes to see if adding plant sterols is worthwhile for you.
  • Lipoprotein(a): A big genetic risk for heart disease
    High Lp(a) levels are a big risk factor for sudden heart attacks. Your Lp(a) levels are mainly controlled by your genetic variants. Check to see if you carry genetic variants that increase or decrease Lp(a).
  • Advanced Glycation End Products
    One cause of many of the diseases of aging is the buildup of advanced glycation end products (AGEs). Your genes interact with your diet – and cooking methods – in the build-up of AGEs. Learn whether this is something that is important for you to focus on. (Member’s article)
  • BMAL1’s impact on the “Big 3”: heart disease, cancer, and diabetes
    A core circadian rhythm gene, BMAL1, influences heart disease risk, diabetes, and cancer. Check your genes and learn how to mitigate the risk.
  • High blood pressure due to AGTR1 gene variants
    There are several causes of high blood pressure. Genetic variants in the AGTR1 gene are strongly linked with blood pressure and there are specific lifestyle changes that should work to change your blood pressure if you carry the variants.
  • Will statins give you muscle pain? What your genes can tell you.
    Statins are one of the most prescribed medications in the world. One side effect of statins is myopathy, or muscle pain and weakness. Your genetic variants are important in whether you are likely to have side effects from statins.
  • Boosting NAD+ to Reverse Aging? Overview of NR and NMN
    Explore the research about how nicotinamide riboside (NR) and NMN are being used to reverse aging. Learn about how your genes naturally affect your NAD+ levels, and how this interacts with the aging process.
  • Saturated Fat and Your Genes
    There has been a decades-long debate about which type of fat is best: saturated fat vs polyunsaturated fat. It may depend on your genes as to which answer is right for you. Learn more about this debate and find out how your genes play a part.
  • Ancestral Diet: Omega-3 and Omega-6 Fatty Acids Impact the FADS1 gene
    We all vary in how well we convert the plant-based omega-3 oils into the DHA and EPA that our body needs. Some people are really poor at this conversion and thus should either eat more fish or consider taking a DHA / EPA supplement. Learn more about how your variants might affect your health.
  • ITGB3: Heart attack risk – with a positive tradeoff
    The PIA2 variant of the ITGB3 gene is linked to an increased risk of blood clots including stroke, heart attack, and DVT. But this variant also comes with a positive trade-off. Learn more with your genetic raw data.
  • C-Reactive Protein Gene: Marker of Inflammation
    Chronic inflammation is the driver of many common diseases such as heart attacks, diabetes, obesity, and autoimmune diseases. C-Reactive Protein is a marker of inflammation. Genetic variants can increase or decrease CRP levels. Check your genetic raw data for risk.
  • Prothrombin: Blood Clot Risk
    Genetic variants in the prothrombin gene increase the risk of blood clots (DVTs). Learn if you carry this risk factor for miscarriage, blood clots, and stroke.
  • Factor V Leiden
    The factor V Leiden genetic mutation significantly increases the lifetime risk of blood clots. Check your genetic data to see if you carry this mutation – and then learn to recognize the symptoms of blood clots.
  • The cheese effect and your genes: tyramine intolerance
    Tyramine intolerance happens when you can’t break it down. Too much tyramine can lead to a hypertensive crisis. Learn more and check your genetic raw data for results. (Member’s article)
  • PCSK9 Gene Variants and Cholesterol
    There are several important variants in the PCSK9 gene. Some variants cause lower LDL-cholesterol and decrease the risk of heart disease by 2-fold. Other variants increase LDL-c and increase the risk of heart disease.
  • Low HDL Levels Can Be Genetic
    HDL cholesterol levels are considered to be about half due to genes with the rest due to diet, infection, etc. Learn more about the genetic variants that influence HDL cholesterol and how it affects heart health.
  • Thiamine – Genetic Variations in Need for B1
    Also known as vitamin B1, thiamine is essential for energy production and brain function. Learn how your genes influence your need for thiamine. (Member’s article)
  • Coffee: Is it right for your genes?
    Wondering how your genes influence your reaction to coffee? Find out if you will benefit from drinking coffee and how this interacts with your genes. (Member’s article)