Resilience: Genetic Variants Involved in Surviving Childhood Trauma

Exposure to childhood trauma, such as exposure to abuse, violence, or repeated stress, can have a long-lasting effect. Adults who were exposed to childhood trauma have higher rates of depression, PTSD, suicide, and anxiety disorders.

The question that researchers have attempted to answer is: Why are some people resilient to childhood trauma while others have lifelong effects. Genetics are a big part of that answer.

The HPA axis (hypothalamic-pituitary-adrenal axis) is thought to play an integral role in the resilience to stress. Several studies have investigated the role of the HPA axis, childhood adversity, and adult depression or anxiety.[ref]  One study concluded, “A history of childhood trauma has longstanding effects on adulthood cortisol responses to stress, particularly in that depressed individuals with a history of childhood trauma show blunted cortisol responses”. [ref]

The HPA axis is basically the interactions and feedback loops between the brain (hypothalamus) and the pituitary and adrenal glands. It regulates things like mood, energy, body temperature, and immune function — as well as the body’s release of cortisol in response to stress.

Corticotrophin-releasing hormone (CRH) is produced in the hypothalamus. CRH, in turn, activates ACTH (adrenocorticotropic hormone). ACTH controls the synthesis of cortisol, mineralocorticoids, and DHEA.  So it is a pathway that starts in the brain and ends with the release of hormones, such as cortisol from the adrenal glands.

CRH release increases anxiety, suppresses appetite, and increases attention – just what you need when a tiger is chasing you, but not good when it is chronically a little elevated. Cortisol levels naturally rise and fall over the course of the day, in rhythm with your body’s circadian clock. When this rhythm is either out of phase or dampened, there can be a cascade of chronic effects.

CRH activates the corticotrophin-releasing hormone receptor, CRHR1. There are several quite common genetic variants of CRHR 1 that have been found to interact with childhood trauma. These variants can either increase or decrease the likelihood of long-term effects, depending on the genotype.

These genetic differences are why some adults have lasting problems with cortisol (or ‘adrenal fatigue’) if they were exposed to traumatic events in childhood – or had chronic stress in their childhood.  Or, to put it the opposite way, these variants are why some adults have no long term problems from childhood trauma.

CRHR1 genetic variants:
These two genetic variants listed below are ‘linked’ in that if you inherit one of them, you are very likely to have the other one also. One is covered on the v4 chip from 23andMe (prior to Aug. 2017), and the other is covered on the newer, v5, data from 23andMe.

Check your 23andMe results for rs242924 (v4):

  • G/G: increased risk of depression, anxiety due to childhood trauma [ref][ref]
  • G/T: somewhat increased risk of depression, anxiety due to childhood trauma.
  • T/T: no increase in the risk of depression, anxiety due to childhood trauma.

Check your 23andMe results for rs110402 (v5):

  • G/G: increased risk of depression, anxiety due to childhood trauma [ref][ref]
  • A/G: somewhat increased risk of depression, anxiety due to childhood trauma.
  • A/A: no increase in the risk of depression, anxiety due to childhood trauma.


If you carry the risk variants and are dealing with depression, anxiety, etc, then talk with your doctor about getting your cortisol levels tested to see if your levels are off – either lower than normal or chronically higher.

Herbal adaptogens, such as ashwagandha and Rhodiola, have been shown to modulate the body’s stress response system, including corticotropin-releasing hormone. [ref]  Both are readily available at health food stores and on Amazon.

Holy Basil, also called tulsi tea, has been shown to inhibit cortisol release through acting on the CRHR1 receptor. [ref] Check your local grocery store for tulsi tea / Holy Basil tea or get it on Amazon (lots of flavors available, I like raspberry peach).

If you have too much corticotropin receptor hormone at night, it can cause sleep problems and disrupt circadian rhythm.[ref]  This can feed back into more stress, more cortisol release. So keeping a consistent sleep schedule and good sleeping environment (no light, cool temperature, no blue light for two hours before bed) should help. Tulsi tea doesn’t have caffeine in it, so try drinking a cup before bed.



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