Diet / Gene Interaction

Should I Take Aspirin to Prevent Heart Disease?

Everyone knows that aspirin protects against heart disease, right? Well, it turns out that aspirin may only protect some people from heart disease, and for others, it can actually slightly increase the risk of heart disease.  It all seems to depend on a variant of the COMT gene. Catechol-O-methyltransferase (COMT) is the gene that codes for an enzyme that breaks down dopamine, epinephrine, and norepinephrine, as well as other substances.  There are many studies on the common genetic polymorphisms of the COMT gene, and most of the studies focus on the neurological aspects of the enzyme. A study published in the Journal of the American Heart Association looked at the effect of a common COMT polymorphism on cardiovascular disease.  The study also looked at the combined effect of the variant along with either aspirin or vitamin E and cardiovascular disease. (more…)

By Debbie Moon, ago
Diet / Gene Interaction

Saturated Fat and Your Genes

There has been a decades-long debate about which type of fat is best: saturated fat or polyunsaturated fat. Those in the paleo and ketogenic world are quick to tout the benefits of saturated fat; the American Heart Association promotes polyunsaturated fats[ref]. And most people remain just a bit confused about the arguments on either side... It may depend on your genes as to which answer is right for you. Individualized diet advice instead of generalities that apply to the majority! Genetic Studies: There have been several studies that investigated the effects of a high saturated fat diet on cardiovascular disease stratified by genetic variants. (more…)

By Debbie Moon, ago


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