APOE and COMT: Cognitive Performance in Aging
Your APOE and COMT genotypes together may impact memory and cognitive function in older age.
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COMT in Pain Disorders
Genetic polymorphisms in COMT affect how we feel certain types of pain. These variants are linked to increased susceptibility to chronic pain disorders.
COMT: How to Optimize Your Supplements for Your COMT Genotype
Some supplements interact with COMT variants to impact the rate at which neurotransmitters are broken down. Check your COMT genotype and discover how this may affect your reaction to different supplements or combinations of supplements.
COMT Gene: Neurotransmitter Levels, Estrogen Metabolism, and SNPs
Wondering why your neurotransmitters are out of balance? It could be due to your COMT genetic variants. The COMT gene codes for the enzyme catechol-O-methyltransferase which breaks down (metabolizes) the neurotransmitters dopamine, epinephrine, and norepinephrine.
Gene Function Explorer
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ME/CFS: Myalgic Encephalomyelitis / Chronic Fatigue Syndrome, Genes, Immune Pathways, and Solutions
Learn which immune, mitochondrial, and genetic pathways—NK cells, NLRP3, interferon, complement, TRP channels, and more—may increase susceptibility to ME/CFS.
Nicotinamide Riboside and NMN: Boosting NAD+ in Aging with Supplements
Explore the research about how nicotinamide riboside (NR) and NMN are being used to reverse aging. Learn about how your genes naturally affect your NAD+ levels and how this interacts with the aging process.
T Cell Exhaustion in Long COVID, ME/CFS, and Cancer: Mechanisms and Solutions
T cell exhaustion reduces immune function in chronic infections, long Covid, and cancer. Explore evidence-based natural interventions, and understand the mechanisms.
PFAS, Your Genes, and Your Health: From Mitochondrial Function to Immune Response
PFAS are persistent “forever chemicals” found in everyday products that are used to make products water-resistant, stain-resistant, and non-stick. Research shows PFAS are associated with reproductive issues, immune suppression, thyroid dysfunction, and more.
Trigger Points, Myofascial Pain Syndrome, and Underlying Causes
Trigger points are hyperirritated knots in the muscle and fascia that can refer pain to a nearby region of the body.
Trace Minerals and Neurocognitive Optimization
Trace minerals affect neurotransmitter levels and neuroinflammation. Getting the right levels of micronutrients can help optimize neurocognitive function.
Hypnosis Genes: Genetic Influences on Hypnosis
Not everyone is equally susceptible to hypnosis. Learn how your genetic variants play a role in how your brain focuses and responds to hypnotic suggestions.
Oxalates: What Your Genes and Diet Say About Oxalate Health Issues
Green smoothies have been a health fad for quite a while now, but these health drinks can be a double-edged sword for some people due to their high oxalate content. Find out if you are genetically prone to kidney stones and what to do about it.
MTHFR Gene Explained: C677T and A1298C Variants, Testing, and Solutions
The MTHFR gene is important for how your body utilizes folate (vitamin B9) for creating neurotransmitters, detoxifying toxicants, and maintaining a healthy heart. It is a key gene in the methylation cycle.
Mast Cells: MCAS, Genetics, and Solutions
Mast cells are essential to your innate immune system, defending against pathogens and allergens. For some people, mast cells can be triggered too easily, giving allergy-like responses to lots of different substances.
Histamine Intolerance: Genetic Report, Supplements, and Real Solutions
Genetics plays a big role in how well your body breaks down histamine. You can use your genetic data to figure out if your genes are part of the reason why you have histamine intolerance.
DHFR and MTHFR: Folic Acid Metabolism
Methylfolate may be a better option than folic acid if you have certain genetic variants in the MTHFR or DHFR genes.
Building Up Iron: Hemochromatosis Mutations
A couple of common mutations can cause you to build up iron, leading to iron overload or hemochromatosis. It is one genetic disease where knowledge is really powerful – you can completely prevent hemochromatosis through blood donations.
Familial Mediterranean Fever: MEFV Gene Variants, Overlapping Conditions, and Solutions
Explore how MEFV mutations drive autoinflammatory flares, the overlap of FMF with fibromyalgia, gout, lupus, and MCAS, and evidence-based options from colchicine to natural anti-inflammatory strategies.
Vitamin B12, MTR & MTRR, and Methylation
There are several genes that can influence your absorption, transport, and need for vitamin B12. Some people need higher amounts of B12, and some people thrive on different forms of B12. Take a look at your genetic data to see if you should up your intake of B12.
Supplements with Genetic Connections
Linking supplements and genetic SNPs so that you can more easily find out what may work for you – and what to be cautious about.
Fibromyalgia: Underlying Causes and Genetic Connections
Learn about the potential causes of fibromyalgia, including inflammation, genetics, and hypersensitivity to pain, along with overlapping conditions that complicate diagnosis.