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Estrogen, Histamine, and Mast Cell Connections, genetic variants that affect histamine and mast cells, genetic variants that affect estrogen receptors

Estrogen, Histamine, and Mast Cell Connections

Mast cells can be more easily triggered in the presence of high estrogen or estrogen-mimicking compounds. Histamine can also trigger mast cell degranulation. Together, this can cause a lot of symptoms related to mast cell activation.

mTOR, how rapamycin works, downsides of rapamycin

Rapamycin, mTOR, and Your Genes

Rapamycin is an antibiotic used as an immunosuppressant, an anti-cancer agent, and to prevent blocked arteries. Rapamycin is now the focus of longevity and healthspan-extending research by inhibiting mTOR.

How HMGB1 acts as an alarmin, escalating the inflammatory response to infection and injury

HMGB1 gene: Inflammatory Response Protein and COVID-19

The HMGB1 protein has a unique role in activating the inflammatory response pathways. Increased HMGB1 levels will call up the troops for a big response to an infection. Discover how genetic variants of this protein vary the risk of cancer, inflammation, and sepsis to name a few.

Fisetin: Antioxidant and Senolytic

Fisetin: Antioxidant and Senolytic

Fisetin is a natural flavonol found in several types of fruits and vegetables and may prove to be a critical anti-aging component. In several recent studies, fisetin clears out senescent cells holding a lot of promise for healthy aging. Learn more about the newest research into this possible longevity compound.