Estrogen, histamine, and mast cell connections

Mast cells can be more easily triggered in the presence of high estrogen or estrogen-mimicking compounds. Histamine can also trigger mast cell degranulation. Together, this can cause a lot of symptoms related to mast cell activation.

Spike Protein, Mast Cells, Histamine, and Heart Rhythms

Do you know of someone with unexplained heart palpitations, spiking blood pressure, dizziness, and tinnitus? Discover how research is linking these symptoms to histamine, mast cells, and the spike protein.

Rapamycin, mTOR, and Your Genes

Rapamycin is an antibiotic used as an immunosuppressant, an anti-cancer agent, and to prevent blocked arteries. Rapamycin is now the focus of longevity and healthspan-extending research by inhibiting mTOR.

COMT: Slow vs. Fast, Interactions with Supplements

Some supplements interact with COMT variants to impact the rate at which neurotransmitters are broken down. Check your COMT genotype and discover how this may affect your reaction to different supplements or combinations of supplements.

HMGB1 gene: inflammatory response protein important in sepsis and COVID-19

The HMGB1 protein has a unique role in activating the inflammatory response pathways. Increased HMGB1 levels will call up the troops for a big response to an infection. Discover how genetic variants of this protein vary the risk of cancer, inflammation, and sepsis to name a few.

Aspirin, colon cancer, and genetics

For some people with specific genetic variants, aspirin may help to prevent colon cancer. Learn more about what the research says and check your genes.

Fisetin: Antioxidant and Senolytic

Fisetin is a natural flavonol found in several types of fruits and vegetables and may prove to be a critical anti-aging component. In several recent studies, fisetin clears out senescent cells holding a lot of promise for healthy aging. Learn more about the newest research into this possible longevity compound.