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DHFR and MTHFR: Folic Acid Metabolism, excess folic acid, the folate cycle

DHFR and MTHFR: Folic Acid Metabolism

Methylfolate and folic acid—what’s the difference? Learn how DHFR and MTHFR variants affect folic acid metabolism, unmetabolized folic acid, cancer and autism risk, BH4 recycling, and how to choose the right supplement for your genes.

Blood Pressure, MTHFR, and Riboflavin

Blood Pressure, MTHFR, and Riboflavin

The common MTHFR C677T variant increases the relative risk of high blood pressure. Learn how to add more Riboflavin (B2) into your diet to reduce risk.

Understanding MTHFR Test Results

Unraveling MTHFR: A Comprehensive Guide The human body is a complex system, and understanding its intricacies can often seem like a daunting task. One such complexity lies in our genes, specifically the MTHFR gene. This gene, and the enzyme it produces, plays a crucial role in our health. However, mutations … Read more

MTHFR_ Going Beyond C677T and A1298C

MTHFR: Going Beyond C677T and A1298C

The MTHFR C677T and A1298C variants get a lot of press, but they do not give the whole picture of the MTHFR gene. Additional variants are impacting the functionality of the enzyme.

MTHFR variants and depression and anxiety

MTHFR, Depression, Anxiety, Symptoms and Treatment

We are all genetically unique, and a common genetic variant in the MTHFR gene causes some people to be more susceptible to having low folate levels. This article explains the research linking MTHFR variants, folate, and depression — and gives you information on how diet or supplements may help.

MTHFR and Migraines, high homocysteine

MTHFR and Migraines

The MTHFR C677T variant increases the risk of migraines. Learn how to check your genetic data and how to mitigate the risk.

MTHFR c677t, symptoms and solutions

MTHFR: How to check your data for C677T and A1298C

Key takeaways: The MTHFR enzyme converts folate (vitamin B9) to its active form, 5-MTHF. Folate is used to create methyl groups, which cells use to synthesize neurotransmitters, detoxify toxicants, methylate DNA, and maintain a healthy heart. The common MTHFR C677T and A1298C variants lower enzyme function (up to ~70–80% for … Read more

Histamine Intolerance, MTHFR, and the Methylation Cycle

Histamine Intolerance, MTHFR, and the Methylation Cycle

Genetics plays a role in how well your body breaks down histamine. Histamine that is out of balance with the body’s ability to break it down can cause symptoms that are collectively known as histamine intolerance. Discover how to check your genes that are involved with histamine levels.

MTHFR variants in Fathers Affect Miscarriage Risk, methylfolate vs folic acid

Dads Matter: MTHFR Variants in Fathers Affect Miscarriage Risk

Dads matter – in conception, pregnancy, and throughout life. It is easy to see how prospective moms need to clean up their diets, exercise, and sleep well before getting pregnant, but recent studies show that a dad’s MTHFR variants also affect infertility and miscarriage risk.

SNP Coverage Checker: Which DNA Test Includes Your SNP

Is that SNP in your DNA test? Type any rsID, paste a list of rsIDs, or search a Genetic Lifehacks article title. You’ll see which DNA test files we checked include each variant, how sure we are, and — where it’s in a report — which Genetic Lifehacks articles explain … Read more

Genetic Lifehacks vs. SelfDecode: Which Is Right for You?

Disclosure: I run Genetic Lifehacks, so weigh my opinion accordingly. I’ve tried to be fair here and to say plainly when the other tool is the better fit. Which is better? If you want an all-in-one platform with its own DNA kit, an AI health coach, a lab analyzer, AI … Read more