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Where relevant, the articles below are linked back to Genetic Lifehacks articles so that you can connect the longevity research to your genes.
Herpes, Gut Bacteria, and the Brain
A Roundup of New Neurodegeneration Research,
A roundup of new neurodegeneration research exploring the viral origins of Alzheimer’s disease, including how herpes simplex virus triggers tau tangle formation and how gut bacteria may provide a pathway for pathogens to reach the brain
MAR 15, 2026
Related article: Cold sores, genetic susceptibility to herpes simplex
Are Motor Neurons the Cause of the Hard Limit on Lifespan?
Examining the evidence.
Once you’ve dodged the big midlife killers like heart disease and cancer, what actually sets the upper limit on how long you can live?Once you’ve dodged the big midlife killers like heart disease and cancer, what actually sets the upper limit on how long you can live? This article explores the case that it may be your motor neurons—the long, energy-hungry nerve cells that drive movement and breathing—rather than your muscles themselves. Drawing on research in sarcopenia, grip strength, gait speed, ALS, and neuromuscular junction aging, it argues that progressive motor neuron loss is a key driver of late-life frailty and the “peaceful passing” we call dying of old age.
MAR 1, 2026
Engineering CAR T cells for Alzheimer’s plaque removal
Groundbreaking new study, and a bigger picture of brain health for longevity.
A look at a groundbreaking new study on using engineered CAR T cells to remove Alzheimer’s plaques, placed in the broader context of brain health for longevity.
FEB 17, 2026
Related article: T cell exhaustion
Photobiomodulation to boost immune response
Using red light to modulate T cell response
Examines the research on using red light (photobiomodulation) to modulate T cell response as a potential immune-boosting tool.
FEB 5, 2026
Related article: Photobiomodulation and your mitochondrial genes
Why We Age: Damage, Programmed, or Both?
Wading through recent papers about the limit of lifespan.
A deep dive into recent scientific papers debating the fundamental question of whether aging is caused by accumulated damage, a programmed biological process, or a combination of both — and what this means for the limits of human lifespan.
JAN 24, 2026
Related articles: Advanced Glycation End Products (AGEs): Genetics, Lifestyle, and Health Span
My current supplement stack for longevity
Looking back at 2025 longevity research studies, and planning for 2026,
A personal, detailed review of the author’s current supplement regimen — including NMN, proline, arginine, and more — reflecting on 2025 longevity research and planning for 2026.
JAN 4, 2026
Related articles: NAD+ (NMN and NR) & Creatine genes
Reversing late-stage Alzheimer’s
A mouse study that gives me hope
Covers a promising mouse study on reversing late-stage Alzheimer’s disease, with caveats about the historical difficulty of translating such studies to humans, while explaining why the mechanism here is uniquely hopeful.
DEC 24, 2025
Related article: Check your APOE type
Rethinking a Hallmark of Aging: Inflammaging May Be Lifestyle, Not Biology
Indigenous populations with high infection rates don’t develop age-related chronic inflammation,
Examines a landmark study in Nature Aging comparing inflammatory markers in industrialized vs. indigenous populations, finding that chronic age-related inflammation may be driven by modern lifestyle rather than being an inevitable biological process.
DEC 19, 2025
Related article: Chronic inflammation and Immune response
Stem Cells, Fatty Acids, and the Biology of Hair Regrowth
Why monounsaturated fatty acids might be the missing piece—and what else your cells need,
Explores why monounsaturated fatty acids may be a missing piece in the biology of hair regrowth, and what other cellular factors stem cells need to regenerate hair follicles.
DEC 13, 2025
Related article: Will you go bald? Genetics and hair loss
Arginine and Alzheimer’s Prevention: Linking Diet, Immunity, and Brain Health
New study on Alzheimer’s and arginine, plus circling back to the T cell exhaustion study,
Explores a new study connecting the amino acid arginine to Alzheimer’s prevention, and connects it back to an earlier article on sucralose consumption and T cell exhaustion.
NOV 29, 2025
Related article: T cell exhaustion
Alzheimer’s Research Points to a New Culprit: Broken Cellular Communication and Altered Gene Expression
Lessons from the SORL1 gene,
NOV 23, 2025
Related article: Genetic Mutations that Protect Against Alzheimer’s Disease
Mitochondrial function, age-related immune decline, and urolithin A
New study that shows promise for inflammaging,
NOV 16, 2025
Related article: Urolithin A for Mitochondrial Health and Muscle Function
BPIFB4: Longevity benefits, new oral formula
It’s a mouse study, but this could be big!,
Covers a new study on BPIFB4 — a gene and protein associated with living past 100 — which acts as a secreted protein that modulates immune response and keeps inflammation in check, with discussion of a promising new oral formula.
NOV 11, 2025
Related article: BPIFB4 Gene: Linked to Longevity and Heart Health
Research Roundup: Telomeres and D3 | 40Hz for Alzheimer’s | GLP-1 RA for longevity
2 interesting long-term, clinical trials with straightforward outcomes for healthspan,
NOV 8, 2025
Related article: Telomere Length: How your Genes affect Telomeres and Aging
Aging vs. Cancer: Lifespan Constraints and Tradeoffs
Does avoiding cancer explain most of what happens in aging?,
NOV 1, 2025
Related article: Telomere Length: How your Genes affect Telomeres and Aging
Research Roundup: Mitochondrial DNA, d-Ribose for Heart Failure
Two quick and interesting studies related to mitochondrial function.,
OCT 18, 2025
Related article: AMPD1 Deficiency: Post-exercise Muscle Soreness
Gut microbiome, artificial sweeteners, and powering the immune system
Provocatively Subtitled: Sucralose kills cancer patients?,
OCT 14, 2025
Related article: Artificial Sweeteners: Sucralose, Aspartame, and Genetic Interactions
Coffee consumption and dementia
Will drinking coffee prevent Alzheimer’s?,
OCT 5, 2025
Related article: Coffee: Benefits based on your genes
Exploring the Supercentenarian
Epigenome, genome, transcriptome, metabolome, proteome, and microbiome study of a 117 year old,
SEP 25, 2025
Related article: Klotho Gene: Increased Longevity and Brain Health
Research Roundup: Valine Restriction | Microbes | Iron in the Brain
Three recent studies on longevity and healthspan,
SEP 17, 2025
Proline for restoring mitochondrial function in aging
A longevity superstar amino acid?,
SEP 14, 2025
Increasing Oxytocin and Inhibiting TGF-beta to Extend Lifespan
In mice – the combo holds promise for extending lifespan and healthspan.
Examines a study showing that the combination of chronic inflammation and insomnia significantly elevates risk of depression, along with practical natural strategies to reduce inflammatory cytokines and improve sleep.
SEP 1, 2025
Related article: Oxytocin Levels: Genetics of the Love Hormone
Longevity Research Roundup: HMGB1 | Thymosin Beta 4
HMGB1 propagates senescence, and Thymosin Beta 4 may help prevent Alzheimer’s,
AUG 24, 2025
Related article: Thymosin Beta 4: Genetics & Supplemental Peptides
Resilience in Aging: Salutogenesis
Promoting immune resilience as a core principle for health,
AUG 20, 2025
Research Roundup: Reversing physical signs of aging
Remineralizing teeth | Old person smell | Skin rejuvenation,
AUG 17, 2025
Two studies giving current hope for Alzheimer’s
Creatine for fast brain changes, and lithium as a micronutrient,
AUG 10, 2025
Longevity Research Roundup: BCAAs, Ultra Processed Foods, and Skin Cancer
3 Interesting studies for this week,
AUG 7, 2025
Related article: Skin Cancer: Genetics and Prevention
A gut metabolite that drives atherosclerosis, diabetes, and more
Imidazole propionate is adding to our understanding of the effects of the multitude within us.,
AUG 3, 2025
Longevity Research Roundup: 3 Things to Know This Week
Interesting New Studies,
JUL 29, 2025
Inflammation + Insomnia = Depression
An interesting study in older adults,
JUL 26, 2025
Related article: Inflammation as a Cause of Depression and Anxiety
Boosting mitochondrial function with light
The science here is pretty cool,
JUL 19, 2025
Longevity Supplements: How many capsules are you swallowing each day?
Question on my mind: Are capsules hurting my gut microbiome?,
JUL 11, 2025
FOXO3: Longevity Gene?
The role of the FOXO3 transcription factor in aging and healthspan,
JUN 23, 2025
Klotho: Anti-aging superstar?
The ins-and-outs of the Klotho protein,
JUN 9, 2025
Sulfur amino acid restriction for longevity?
Methionine or Cysteine? Pulling the amino acid levers for weight loss and healthspan.,
MAY 28, 2025
Blocking NLRP3 to Decrease Alzheimer’s Risk
How an AIDS drug reduces the risk of Alzheimer’s – plus natural options that affect the same pathway, MAY 18, 2025
Fisetin for clearing out senescent cells
Is it worth trying?, MAY 12, 2025
Related article: Fisetin: Antioxidant and Senolytic
Blood-Brain Barrier: Key to Longevity
Gut mucosal barrier, blood-brain barrier – protection keeps us alive., APR 30, 2025
Related article: Gut Mucosal Barrier & Mucin Genes
Does nicotinamide riboside increase atherosclerosis?
A new mouse study adds to a genetics study from last year., APR 18, 2025
Related article: Nicotinamide Riboside and NMN: Boosting NAD+ in Aging
miRNA Regulation and Aging: The Epigenetic Levers of Lifespan
How miRNAs change gene expression and cause the changes seen as we age., APR 6, 2025
Related article: miRNA: What It Is and How It Works
A new pathway to target for Alzheimer’s disease prevention
Genetics research on familial Alzheimer’s highlights the importance of Reelin, MAR 23, 2025
Researchers untangle an important driver of the aging process
“EDA2R is a Ubiquitous Hallmark of Aging”, MAR 10, 2025
Testing my microplastics level
What do the results mean?
A personal account of the author testing her own blood for microplastics after months of reducing plastic exposure in her kitchen, with results showing she landed in the bottom quartile of a health-conscious reference population.
FEB 28, 2025
Related article: Microplastics Research Roundup
New study on slowing aging
Looking at fish oil, vitamin D, and exercise to slow down aging…
Covers a groundbreaking new study on mechanisms or interventions for slowing the aging process, one of the most popular articles on the newsletter.
FEB 16, 2025
GHK-Cu Peptide in Skin, Hair, and Lung Health
More than just fighting wrinkles?, FEB 9, 2025
Longevity for the 99%
4 supplements for improving healthspan without breaking the bank, FEB 2, 2025
Extending lifespan with miRNAs
microRNAs to the rescue?, JAN 24, 2025
Epigenetic Aging Due to Mutations
As your cells replicate and regenerate, DNA mutations happen, JAN 17, 2025
l-glutamine for gut barrier function
Does longevity begin and end with gut barrier function?, JAN 8, 2025
Alpha-ketoglutarate for longevity
Worth taking? I’ll let you decide…, DEC 21, 2024
Related article: Alpha-Ketoglutarate (AKG) Supplements: What the Research Actually Shows
Microplastics are a real problem for healthspan
And here’s what I’m doing about it., DEC 3, 2024
Related article: Microplastics Research Roundup
Autodigestion?
Are powerful digestive enzymes escaping to cause the ravages of aging?, NOV 20, 2024
New theory of why we break down in old age: Leaking digestive enzymes cause autodigestion, tissue damage, and inflammation
Gut barrier function, emulsifiers, and digesting your own organs,
Presents a provocative new theory that leaking digestive enzymes cause autodigestion — leading to tissue damage and chronic inflammation — as a key driver of age-related breakdown in the body.
NOV 10, 2024
Testing what works for reversing biological age
Or is it just a test of the tests?
Analyzes a Yale preprint that aggregated 51 different intervention studies and ran them through epigenetic clock models to determine which supplements, diets, and lifestyle changes actually move the needle on biological age.
NOV 1, 2024
C15:0 Pentadecanoic Acid
Dietary sources and supplement options, OCT 28, 2024
Related article: C15:0 Pentadecanoic Acid
Minimizing light at night, maximizing light during the day
The low-hanging fruit for longevity, OCT 18, 2024
Related articles: Alzheimer’s and Light at Night; Why Light at Night Increases Cancer Risk
Mitigating Microplastic Risk
Will microplastics doom my longevity and healthspan?, OCT 5, 2024
Related article: Microplastics Research Roundup
Alzheimer’s Prevention Strategies
A “roundup” of what the research shows., SEP 8, 2024
MOTS-c: mitochondrial peptide that mimics exercise
A study in the journal Nature explains the research on a fascinating peptide known as MOTS-c., AUG 23, 2024
New studies on preventing Alzheimer’s
Two interesting new studies came out in the past few weeks on preventing or reversing Alzheimer’s disease., AUG 9, 2024
Can eggs prevent Alzheimer’s?
According to a new study, just one egg a week cuts the risk of Alzheimer’s disease considerably., JUL 26, 2024
IL-11 and Extending Healthspan and Lifespan
New study out showing 25% increased lifespan in mice when targeting IL-11, JUL 19, 2024
Glycine for improving slow-wave (deep) sleep
A recent study on sleep and dementia points out (once again) that sleep is essential for good health in aging., JUL 12, 2024
Related article: Boost Slow-Wave Sleep with Glycine Before Bed
Gut Microbiota and Alzheimer’s Disease: Genetic Association Study
The following is a summary of a 2023 study along with several newer studies on the gut microbiome and Alzheimer’s, JUL 3, 2024
Luteolin: Neuroprotective, Anti-inflammatory, Antihistamine
Staying healthy as we age – a natural brain health supplement, JUN 26, 2024
Related article: Luteolin: Antihistamine, Memory, and Brain Fog
Longevity and Genetic Trade Offs
Genetic variants are slight changes in a gene that can affect the function of genes., JUN 14, 2024
Epigenetic Tests for Biological Age
Decrease your biological age by 5 years with one easy step!, JUN 8, 2024
Do microplastics shorten lifespan?
Are they even worth worrying about?, JUN 1, 2024
Related article: Microplastics Research Roundup
Targeting cellular senescence with natural compounds
Beating back the ravages of time?, MAY 24, 2024
TNF-alpha and Inflammaging
Natural TNF inhibitors, MAY 13, 2024
Genetics and Healthspan:
Teasing out what’s actually important, MAY 8, 2024
Serine for cognitive enhancement
Why would serine be important for preventing neurodegenerative diseases?, APR 30, 2024
Methylene Blue: Mitochondrial function, cognitive benefits?
Looking at the studies on MB for Alzheimer’s prevention and improving cognitive function, APR 26, 2024
Related article: Methylene Blue: Genetic Connections and Research Studies
Intermittent Methionine Restriction for Longevity
Most of the benefits without the drawbacks, APR 19, 2024
Preventing muscle loss in aging
Kind of like porn, we all know aging when we see it., APR 10, 2024
Related article: Creatine: Boosting Muscles and Increasing Brain Power
Folate, folic acid, methylfolate
Balancing cellular growth and health with avoiding cancer, APR 5, 2024
Related article: DHFR and MTHFR: Folic Acid Metabolism
Low dose lithium reduces cellular senescence
A recent study shows that low-dose lithium may act as a senolytic. This has important implications in healthy aging – including preventing…, APR 2, 2024
Related article: Lithium Orotate and Vitamin B12: Benefits for Mood and Cognitive Support
Biggest Impacts on the Aging Brain
New study on genetics, brain changes, and dementia, MAR 28, 2024
Geroplasticity: Is Rejuvenation of Aging Cells Possible?
Turning back time?, MAR 23, 2024
Plasmalogens and Alzheimer’s Prevention
Let’s be honest, no one wants to increase their longevity just to have years of Alzheimer’s or dementia., MAR 20, 2024
Related article: Plasmalogens: Healthy Brain Aging and More
Gum Disease is Linked to Alzheimer’s
Activating Microglia in the Brain, MAR 17, 2024
Related article: Gingivitis: The Genetic Connection between Gum Disease, Inflammation, and Overall Health
Spermidine and Healthspan
Sorting through the research, MAR 10, 2024
Alzheimer’s Trial with 4 Common Supplements
The low hanging fruit – improving cognitive function with vitamins and natural supplements, MAR 2, 2024
Supplementing with Glycine and NAC:
Reduce oxidative stress, increase mitochondrial function, JAN 24, 2024
Related article: Boost Slow-Wave Sleep with Glycine Before Bed
Stopping Inflammaging: SPMs to the rescue?
The resolution of inflammation is an active process, JAN 16, 2024
Related article: Specialized Pro-resolving Mediators (SPMs): The Resolution of Inflammation
Longevity and Genetic Trade Offs
Or… reproduction vs. not getting cancer in old age, JAN 9, 2024
B vitamins in Mild Cognitive Impairment
Brain health in aging (and middle-aging), JAN 2, 2024
Related article: Vitamin B6: Genetics, Absorption, and Deficiency
HMB and Vitamin D
Improving functionality in older adults by improving muscle mass, DEC 22, 2023
Related article: HMB Supplement and Muscle Mass
Taurine Deficiency in Aging
Will taurine supplements make you live longer?, OCT 17, 2023
Related article: Taurine: Healthspan, Mitochondrial Function, and Heart Health
Stimulating neurogenesis even in old age
Reversing cognitive declines in aging through stimulating the olfactory bulb, SEP 26, 2023
Longevity Lifehacks: Preventing Alzheimer’s
The stats on Alzheimer’s are grim… but we can do something to change them., AUG 11, 2023