Raynaud’s: Causes, Symptoms, and Genetics
Do your fingertips turn white and blue when cold? Discover the causes and symptoms of Raynaud’s syndrome and your genetic susceptibility.
Autoimmune Diseases
Genetic susceptibility is part of the picture in autoimmune diseases. Genes combine with environmental factors, such as toxins, pathogens, diet, and lifestyle, for most autoimmune diseases.
Understanding the genetic variants that you carry may help you to find the solutions that work for you. Learn how your genes impact different biological pathways involved in autoimmune conditions.
Where to start?
- Find out if you are likely to carry the HLA-B27 type.
- What about Low-dose Naltrexone?
- Do you have the HLA types for celiac?
- What about mast cell activation syndrome?
Members: The Autoimmune Topic Summary Report gives you an overview of all your genetic variants related to autoimmune diseases.
Latest articles about Autoimmunity:
Celiac Genes: How to Check Your Raw Data
Celiac disease is caused by a combination of environmental factors (eating gluten, other factors) and having the genetic variants that cause susceptibility to the disease. Without the genetic susceptibility, you won’t have celiac.
Thyroid Hormones: Genes, Hypothyroidism, and T4/T3 Conversion
The thyroid is a master regulator controlling many of your body’s systems. It is integral for metabolism and body temperature. Learn more about specific thyroid-related variants and check your genetic raw data.
HLA-B27: Genetic Variant That Increases Susceptibility to Autoimmune Diseases
The HLA-B27 serotype is linked to an increased risk of several autoimmune diseases, including ankylosing spondylitis, psoriatic arthritis, and IBD.
Familial Mediterranean Fever: Mimics fibromyalgia, arthritis, inflammation
Familial Mediterranean fever (FMF) is a genetic condition of inflammatory episodes that cause painful joints, pain in the abdomen, or pain in the chest. It is most often accompanied by a fever. FMF is often misdiagnosed as various pain-related conditions such as fibromyalgia, myofascial pain syndrome, or gouty arthritis.
Low-Dose Naltrexone: LDN & Genetics
The use of low dose naltrexone (LDN) can be an effective treatment for some autoimmune diseases, pain syndromes, and chronic fatigue syndrome. Learn how this opioid antagonist works on the immune system and how your genetics can play a part in its efficacy.
Multiple Sclerosis: Genetic Factors and Susceptibility to MS
MS susceptibility is linked to both genetic causes and environmental factors. Learn how those two combine – and possible solutions.
Breast Implant Illness: The Interplay of Genetics and Symptoms
What is Breast Implant Illness (BII)? Learn more about this illness, its research, and possible genetic connections to autoimmune conditions.
Sjogren’s: Causes, Genes, Solutions
Are you dealing with dry eyes and dry mouth? Sjögren’s syndrome is an autoimmune disorder that affects moisture-producing glands. Discover the underlying causes of Sjögren’s syndrome and the genetic variants that increase susceptibility.
Pernicious Anemia: Genomics and B12 Deficiency
Pernicious anemia is a B-12 deficiency anemia caused by an autoimmune attack on the cells that produce intrinsic factor. Learn how genes impact susceptibility to pernicious anemia.
Alopecia Areata: Reasons for Rapid Hair Loss
Alopecia areata is an autoimmune-like disorder in which the immune system attacks the hair follicle. Learn about the triggers of alopecia areata, why the hair falls out, genetic variants that increase susceptibility, and possible treatment options.
Postural Orthostatic Tachycardia Syndrome (POTS): Genetics, Causes, Symptoms, and Management Strategies
POTS (postural orthostatic tachycardia syndrome) is a problem with the way that your autonomic nervous system regulates heart rate.
There are multiple triggers or root causes of this syndrome, and genetic variants can increase your risk for POTS.
Guillain-Barré Syndrome: Genetic Risk Factors and Known Triggers
This article dives into the research on Guillain-Barré syndrome, explaining the course of the disease, and covering the genetic variants that increase the relative risk of this serious autoimmune disease.
IL-17: Chronic Inflammation & Autoimmune Risk with IL17A, IL17F
The IL17 gene codes for an important part of the immune system. When it is overactive, IL-17 can contribute to the risk of autoimmune diseases including rheumatoid arthritis and inflammatory bowel disease.
Inclusion Body Myositis: Genomics and Solutions
Inclusion body myositis is a progressive, chronic condition that causes muscle weakness. It may be an interplay between inflammation, the dysregulation of proteins, mitochondrial dysfunction, and changes to autophagy. Somewhere in the mix, autoimmunity may be triggering it.
Vaccines, Genetics, and Autoimmune Diseases: A roundup of the research
A look into the research-backed studies showing how certain vaccines may slightly increase the absolute risk of autoimmune diseases in susceptible individuals. (Member’s article)
PTPN22 and Autoimmune Diseases
The PTPN22 gene plays a pivotal role in that balance, and genetic variants (SNPs) in PTPN22 increase your risk of autoimmune conditions such as vitiligo, alopecia, RA, type 1 diabetes, and autoimmune thyroid diseases. (Member’s article)
Rheumatoid Arthritis: Genetics, Root Causes, and Treatment Research
Rheumatoid arthritis is caused by an immune system attack on the joints, causing thickening and inflammation of the joint capsule. It is caused by a combination of genetic susceptibility and environmental triggers.
CTLA4 Gene: Autoimmune Risk Factor
The CTLA4 gene codes for a protein that is important in the immune system. It acts as a checkpoint that can downregulate your immune system response. Genetic variants in the CTLA4 gene can increase your risk for several different autoimmune diseases. (Member’s article)
Lupus: Genetics, Root Causes, and Possible Solutions
Lupus is a complex autoimmune disease that can impact several different systems in your body. Learn more about how your genetic variants impact the “why” for this autoimmune disease.
Tinnitus and Meniere’s Disease: Genetic Susceptibility to Ringing in Your Ears
Genetics plays a role in both Meniere’s disease and tinnitus. Understanding your genetic susceptibility may help point you to the right solutions.
Psoriasis Genes: How Genetics Point to Individualized Solutions
Psoriasis is an autoimmune condition that causes dry, sometimes itchy patches of skin. It is caused by the immune system attacking your skin cells, speeding up the turnover of the cells. Genetics plays a role in your susceptibility.
Genes Involved in Autophagy
Just like you need to take out the trash and recycle your plastics and cans, your body also needs to clean up cellular waste and recycle proteins. This process is called autophagy, and it is incredibly important in preventing the diseases of aging. (Member’s article)