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How mast cells release histamine and other mediators in mast cell activation syndrome, and the genetics that influence MCAS

Mast Cells: MCAS, Genetics, and Solutions

Mast cells are essential to your innate immune system, defending against pathogens and allergens. For some people, mast cells can be triggered too easily, giving allergy-like responses to lots of different substances.

The genetic and inflammatory causes of chronic back pain

Back Pain: Genetics, Root Causes, and Solutions

For some people, back pain is a daily occurrence that drastically affects their quality of life. For others, it may be an intermittent nagging problem, often without rhyme or reason. Your genes play a role in whether disc degeneration gives you back pain.

Why Lyme disease becomes chronic for some people and the gene variants involved

Chronic Lyme: Genetic Susceptibility

The interesting thing about Lyme disease is that the genetic variants you carry impact both how the disease affects you and how well antibiotics work for you. Learn whether your genetic variants are linked to post-treatment Lyme disease symptoms such as joint pain. (Member’s article)

Estrogen, Histamine, and Mast Cell Connections, genetic variants that affect histamine and mast cells, genetic variants that affect estrogen receptors

Estrogen, Histamine, and Mast Cell Connections

Mast cells can be more easily triggered in the presence of high estrogen or estrogen-mimicking compounds. Histamine can also trigger mast cell degranulation. Together, this can cause a lot of symptoms related to mast cell activation.

ABCC11 Graphical Abstract: Body odor and ear wax. Variants cause body odor and wet earwax.

ABCC11 Gene: Ear Wax and No Body Odor

The ABCC11 gene determines both the type of earwax a person has and their armpit odor. Learn more about how a change in a single spot in the DNA of this gene can cause the gene not to function.

Genes Involved in Autophagy

Genes Involved in Autophagy

Just like you need to take out the trash and recycle your plastics and cans, your body also needs to clean up cellular waste and recycle proteins. This process is called autophagy, and it is incredibly important in preventing the diseases of aging. (Member’s article)