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Inflammation and Immune Response

Genetic variants influence our immune response, affecting both our ability to combat pathogens and our susceptibility to chronic inflammation. For example, we are all unique in our response to different pathogens. Certain variants in inflammatory cytokine genes, such as TNF-alpha, may increase susceptibility to chronic inflammatory conditions while at the same time increasing your ability to fight off specific viruses or bacteria.

You can use your genetic data to understand which pathways are likely involved for you, and then use the lifehacks sections to discover the right solution for your genes.

Where to start? 

Overview of chronic inflammation  TNF-alpha: Elevated inflammatory cytokines
Genes involved in fatigue The resolution of inflammation is an active process
Root causes of migraines Asthma and lung inflammation
NLRP3 Inflammasome Emulsifiers and gut inflammation

Summary Reports for Members:

Inflammation Summary Immune System Summary Report

Latest articles about Inflammation and Immune Health:

COMT and Chronic Pain, Fibromyalgia, chronic back pain, natural supplements to avoid for slow COMT

COMT in Pain Disorders

Genetic polymorphisms in COMT affect how we feel certain types of pain. These variants are linked to increased susceptibility to chronic pain disorders.

Lyme disease symptoms, chronic Lyme symptoms, genetics involved with Lyme disease

Chronic Lyme: Genetic Susceptibility

The interesting thing about Lyme disease is that the genetic variants you carry impact both how the disease affects you and how well antibiotics work for you. Learn whether your genetic variants are linked to post-treatment Lyme disease symptoms such as joint pain. (Member’s article)

Symptoms of IgA deficiency, Genetic variants that influence IgA deficiency, ways to improve IgA levels

Low IgA and Selective IgA Deficiency

Partial IgA deficiency, which affects up to 1% of the population, can have a genetic component and overlaps with some autoimmune diseases.

Lymphedema: Causes and Genetic Pathways

Lymphedema: Causes and Genetic Pathways

Lymphedema can be caused by various factors such as a traumatic injury, genetics, or even cancer. Discover how your genetics influence the risk of developing the condition.

ITGB3: PlA1/A2 variant and clotting risk

The PlA2 variant of the ITGB3 gene is linked to an increased risk of blood clots including stroke, heart attack, and DVT. But this variant also comes with a positive trade-off with reduced risk of hantavirus infection severity.

Estrogen, Histamine, and Mast Cell Connections, genetic variants that affect histamine and mast cells, genetic variants that affect estrogen receptors

Estrogen, Histamine, and Mast Cell Connections

Mast cells can be more easily triggered in the presence of high estrogen or estrogen-mimicking compounds. Histamine can also trigger mast cell degranulation. Together, this can cause a lot of symptoms related to mast cell activation.

IL-13 Asthma risk, natural inhibitors of IL-13, IL-13 genetic variants

IL-13: Elevating Th2 Immune Response and Asthma risk

Interleukin-13 (IL-13) is a signaling molecule important in the immune response. Excessive IL-13 can tip you toward a Th2-dominant immune response, and variants increase the risk of allergies and asthma.

APOBEC3 Family of Genes

APOBEC3 Family of Genes

The APOBEC3 family of enzymes has a unique way of stopping viruses from replicating. Your genes can affect whether the virus becomes inactive or more virulent.

Spike-Protein-Mast-Cells-Histamine-and-Heart Rhythms

Spike Protein, Mast Cells, Histamine, and Heart Rhythms

Do you know of someone with unexplained heart palpitations, spiking blood pressure, dizziness, and tinnitus? Discover how research is linking these symptoms to histamine, mast cells, and the spike protein.

Alopecia Areata: Genetic Reasons for Rapid Hair Loss

Alopecia Areata: Reasons for Rapid Hair Loss

Alopecia areata is an autoimmune-like disorder in which the immune system attacks the hair follicle. Learn about the triggers of alopecia areata, why the hair falls out, genetic variants that increase susceptibility, and possible treatment options.

CCR5 Gene, Immune Response, Mutation-that-blocks-you-from-getting-AIDS-or-HIV

Mutation that blocks you from getting AIDS or HIV

The CCR5 gene is an important player in the immune response. A mutation in the CCR5 gene, called the Delta32 mutation, significantly reduces the chance of an HIV infection.