Fibromyalgia: Underlying Causes and Genetic Connections
Learn about the potential causes of fibromyalgia, including inflammation, genetics, and hypersensitivity to pain, along with overlapping conditions that complicate diagnosis.
Inflammation and Immune Response
Genetic variants influence our immune response, affecting both our ability to combat pathogens and our susceptibility to chronic inflammation. For example, we are all unique in our response to different pathogens. Certain variants in inflammatory cytokine genes, such as TNF-alpha, may increase susceptibility to chronic inflammatory conditions while at the same time increasing your ability to fight off specific viruses or bacteria.
You can use your genetic data to understand which pathways are likely involved for you, and then use the lifehacks sections to discover the right solution for your genes.
Where to start?Â
Summary Reports for Members:
| Inflammation Summary | Immune System Summary Report |
Latest articles about Inflammation and Immune Health:
Asthma Genes: Understanding your Genetic Pathways
Genes and environmental factors combine to cause asthma. Learn how your genes impact the pathways involved in the different types of asthma.
Rosacea, Genetics, and Solutions
Rosacea is a chronic inflammatory skin condition that is driven by upregulated inflammation. Learn how your genes interact with environmental factors to cause rosacea.
Chronic Sinus Infections: Genetics, Reasons, Solutions
Genetics plays a role in the likelihood of having chronic sinus problems. This article looks at the genetic reasons driving some people to have chronic sinus infections.
IL-17: Chronic Inflammation & Autoimmune Risk with IL17A, IL17F
The IL17 gene codes for an important part of the immune system. When it is overactive, IL-17 can contribute to the risk of autoimmune diseases including rheumatoid arthritis and inflammatory bowel disease.
Chronic Inflammation: Causes and Natural Solutions
Take a deep dive into the causes of chronic inflammation and learn how to target specific inflammatory pathways to reverse or prevent chronic disease.
Long Covid: Genetics Research, Root Causes, and Possible Solutions
Long Covid is the persistence of symptoms after having COVID-19. Learn more about the underlying causes and treatments backed by the newest research.
Avoiding Getting Sick: Research-backed Ways to Prevent Covid, Colds, and Flu
Explore the research-backed strategies for preventing or managing respiratory illnesses. Don’t let a cold get you down this year.
MRGPRX2: Mast Cells, Itching, & Drug Hypersensitivity Reactions, Including Fluoroquinolones
MRGPRX2 is a recently discovered mast cell receptor. It is linked to drug hypersensitivity reactions as well as asthma, rosacea, and IBD.
Gingivitis: The Genetic Connection between Gum Disease, Inflammation, and Overall Health
You brush, you floss, and your gums still bleed… perhaps you carry some of the genetic variants associated with gingivitis? Check your genetic data to see. (Member’s article)
Osteoarthritis: The Role of Genetics and Natural Solutions
Inflammation and breakdown of cartilage are at the root of osteoarthritis. Learn how your genes impact the pathways involved in arthritis.
Acne: Root Causes, Genetic Variants, & Personal Solutions
Acne is up to 80% genetic. Learn how your genes, hormones, diet, and inflammation drive breakouts—and get personalized, research-backed solutions using your 23andMe or AncestryDNA data.
COMT in Pain Disorders
Genetic polymorphisms in COMT affect how we feel certain types of pain. These variants are linked to increased susceptibility to chronic pain disorders.
Chronic Lyme: Genetic Susceptibility
The interesting thing about Lyme disease is that the genetic variants you carry impact both how the disease affects you and how well antibiotics work for you. Learn whether your genetic variants are linked to post-treatment Lyme disease symptoms such as joint pain. (Member’s article)
Genetic Variants that Increase Susceptibility to Lyme Disease
Lyme disease recovery can vary. Whether you recover quickly or have chronic symptoms that include joint pain or arthritis, it may be due to the genetic variants that you carry.
Low IgA and Selective IgA Deficiency
Partial IgA deficiency, which affects up to 1% of the population, can have a genetic component and overlaps with some autoimmune diseases.
Dental Implants: Genetics & Reducing the Risk of Implant Failures
Are you considering a dental implant? Failure rates of dental implants are fairly low but still carry some risk. Genetic variants can influence the likelihood of long-term success.
Lymphedema: Causes and Genetic Pathways
Lymphedema can be caused by various factors such as a traumatic injury, genetics, or even cancer. Discover how your genetics influence the risk of developing the condition.
ITGB3: PlA1/A2 variant and clotting risk
The PlA2 variant of the ITGB3 gene is linked to an increased risk of blood clots including stroke, heart attack, and DVT. But this variant also comes with a positive trade-off with reduced risk of hantavirus infection severity.
Fatigue: Root Causes, Genetics, Personalized Solutions
Are you always tired even when you know you slept well? Discover more about the newest research on fatigue and how genetic susceptibility plays a part for some people.
Estrogen, Histamine, and Mast Cell Connections
Mast cells can be more easily triggered in the presence of high estrogen or estrogen-mimicking compounds. Histamine can also trigger mast cell degranulation. Together, this can cause a lot of symptoms related to mast cell activation.
Acupuncture and Genomics: Who is more likely to respond?
Have you tried acupuncture? This treatment has been around for thousands of years but did you know that your genetic variants can impact how well you respond?
Tendinitis (Tendonitis): Genes, Inflammation, and Targeted Solutions
Do you have problems with your tennis elbow, rotator cuff, knees, or Achilles tendon? Discover how your genes influence the risk of having tendon problems.
APOBEC3 Family of Genes
The APOBEC3 family of enzymes has a unique way of stopping viruses from replicating. Your genes can affect whether the virus becomes inactive or more virulent.
Small Fiber Neuropathy: Genetics, Causes, and Possible Solutions
Small Fiber Neuropathy (SFN) results in burning pain, numbness, odd sensations, or autonomic nervous system issues. Learn more about the possible causes and potential solutions to this debilitating disorder.