Gut Mucosal Barrier: Foundational and Underappreciated
Your gut mucosa protects you from microbes in the gut, your own digestive enzymes, and toxins from the environment. Learn what you can do to keep your gut mucosal barrier healthy.
Search Results for: comt
Factor V Leiden Gene: Increased Risk of Blood Clots
The factor V Leiden genetic mutation significantly increases the lifetime risk of blood clots. Check your genetic data to see if you carry this mutation – and then learn to recognize the symptoms of blood clots.
Klotho Gene: Increased Longevity and Brain Health
The Klotho protein is involved in many of the diseases of aging. Learn more about this gene and find out how your Klotho variants may impact healthy aging.
FTO and m6A Methylation
Recently, researchers discovered that FTO is an m6A eraser that removes methyl groups from mRNA. This discovery has opened up huge avenues of research on topics from cancer to immune response to heart disease.
Dante Labs: How to Download and Convert to 23 and Me format
A step-by-step on how to convert the Dante Labs whole-genome file into a format that looks like 23 and Me or AncestryDNA raw data for use on Genetic Lifehacks.
Acne: Root Causes & Personal Solutions
Acne is thought to be 80% heritable. Learn how your genetic variants increase your risk of acne and find specific solutions that work for those genetic pathways.
Glutamate: Synthesis, transport, and supplement interactions
Glutamate is synthesized from glutamine or alpha-ketoglutarate. Imbalanced glutamate levels play a role in several neurological disorders.
Rapamycin, mTOR, and Your Genes
Rapamycin is an antibiotic used as an immunosuppressant, an anti-cancer agent, and to prevent blocked arteries. Rapamycin is now the focus of longevity and healthspan-extending research by inhibiting mTOR.
Blood type and coronavirus susceptibility
Researchers are finding that blood type may play a role in the susceptibility to coronavirus (COVID-19). While this may seem strange at first, blood type actually influences susceptibility and severity of several different pathogenic diseases. (Member’s article)
Dante Labs Whole Genome Sequencing – Reports Review
A personal experience review and opinion on the reports offered with Dante Labs’ whole-genome sequencing.
Gallstone Genes
The genetic link to gallstones centers around the genes involved in regulating the absorption of cholesterol from plants and the excretion of cholesterol from the body. Learn more about the genetic variants that increase your risk.
Oxytocin Levels: Genetics of the Love Hormone
Oxytocin is called the love hormone. Genetic variants in the OXT gene are linked to being more social and empathetic vs being more of an introvert.
Saffron Extract: What does the research show?
Recent clinical trials show that saffron extract is as effective as standard medications in some people for ADHD, Alzheimer’s, major depressive disorder, and high cholesterol.
CYP1A2 Gene: Fast or Slow Caffeine Metabolizer?
The CYP1A2 gene breaks down caffeine, several major prescription drugs, and interacts with smoking. Learn how your genes influence caffeine metabolism and more.
Rheumatoid Arthritis: Genetics, Root Causes, and Treatment Research
Rheumatoid arthritis is caused by an immune system attack on the joints, causing thickening and inflammation of the joint capsule. It is caused by a combination of genetic susceptibility and environmental triggers.
Color TV has made us fat: melatonin, genetics, and light at night
Melatonin is vital to good health — impacting weight, cancer, Alzheimer’s, and more. Learn how your genes interact with melatonin.
Ordering Lab Tests On Your Own
The best way to know if a genetic variant is affecting you is usually to see where you stand with a blood test.
News and Research: Core circadian clock function vital for regenerating insulin producing cells
BookmarkStudy title: The core clock transcription factor BMAL1 drives circadian β-cell proliferation during compensatory regeneration of the endocrine pancreas Journal Genes & Development, Nov. 2020 Press Release from the University of Geneva on this study: Some parts of our body, such as the skin or the liver, can regenerate after … Read more
Decrease your diabetes risk with coffee?
Does coffee increase or decrease your risk of prediabetes? Learn more about coffee consumption and your genetic risk. (Member’s article)
Vitamin B6: Genetics, Absorption, and Deficiency
Vitamin B6 is an important co-factor in hundreds of different enzymatic reactions. Low levels of B6 are linked to an increased risk of diabetes, cardiovascular disease, neurodegenerative diseases, and cancer. B6 is also essential for reducing oxidative stress and inflammation.
News and Research: A PCSK9 mutation that protects against disease
Canadian researchers have discovered that a rare genetic variant in the PCSK9 gene increases longevity through decrease heart disease and liver injury.
Estrogen, Histamine, and Mast Cell Connections
Mast cells can be more easily triggered in the presence of high estrogen or estrogen-mimicking compounds. Histamine can also trigger mast cell degranulation. Together, this can cause a lot of symptoms related to mast cell activation.
Specialized Pro-resolving Mediators (SPMs): The Resolution of Inflammation
Chronic inflammation is at the root of all diseases. New research discusses how pro-resolving mediators are the key to the resolution of inflammation.
Serotonin 2A receptor: Psychedelic response and Alzheimer’s disease
Learn how new research on brain aging and dementia connects the serotonin 2A receptor with psychedelics, brain aging, and Alzheimer’s.
Debunking the “blood-type diet”
Does the science back up the idea that you can lose weight solely based on your blood type? The article explains the different ABO blood types, breaks down the core ideas of a blood type diet, and offer some food for thought on how to approach these methods. (Member’s article)