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CYP2C9 Genetic Variants and Drug Metabolism

Have you ever wondered why certain medications don’t work well for you? Genetic variants can change how fast or how slow the medication is broken down in your body. Learn how the CYP2C9 variants impact quite a few prescription medications.

Nrf2 Pathway: Increasing the body’s ability to get rid of toxins

The Nrf2 (Nuclear factor erythroid 2–related factor) signaling pathway regulates the expression of antioxidants and phase II detoxification enzymes. It is a fundamental pathway important in how well your body functions. Your genetic variants in the NFE2L2 gene impact this NRF2 pathway.

CYP2A6: Breaking down nicotine and other medications

How many cigarettes a day a person smokes – and how hard it is for them to quit – is at least partly dependent on the CYP2A6 gene. This enzyme also metabolizes several important cancer drugs.

Should you eat organic? Detoxifying Neonicotinoids

Is buying organic worth the extra cost? Pesticides that are sprayed on conventionally grown foods affect people differently. Some people carry genetic variants that decrease their ability to detoxify specific pesticides, others may be more resilient. This is Part One in a multipart series on pesticide detoxification. (Member’s article)

Allergy Medicine: Why Fexofenadine Works Better for Some People

Ever wonder why a certain medication may work great for a friend and do nothing for you? One reason could be the genes involved in transporting the medication into and out of your cells. This article looks at the research studies on fexofenadine and the Multidrug Resistance Protein variants.

Alcohol Genes: Alcohol Metabolism Rate

Wondering why you don’t react the same way to alcohol as your friends do? Some people metabolize alcohol faster leaving a build-up of acetaldehyde. Learn more about why this can be a health problem for some.

Will statins give you muscle pain?

Statins are one of the most prescribed medications in the world. One side effect of statins is myopathy, or muscle pain and weakness. Your genetic variants are significant in whether you are likely to have side effects from statins.

BPA: How Your Genes Influence BPA Detoxification

BPA, a chemical found in some plastics, has been linked to a variety of health issues in people. Learn more about BPA and the research into genetic responses to this chemical.

Should you eat organic? Detoxifying Organophosphates

Is buying organic worth the extra cost? There isn’t a one-size-fits-all answer to that question. Pesticides that are sprayed on conventionally grown foods affect people differently. Some people carry genetic variants that decrease their ability to detoxify specific pesticides, others may be more resilient. This is Part Two in a multipart series on pesticide detoxification. 

Opioid Receptors: Variants and addiction

Genetic variants in the ORPM1 gene impact both the amount of pain someone experiences and their response to opioid drugs. These variants are also important in susceptibility to opiate addiction. (Member’s article)

modafinil genes

Is the nootropic drug modafinil likely to work for you?

Modafinil is being used as a nootropic drug that increases alertness and gives a sense of well-being — to some users. Like most drugs, individual results seem to vary. Discover if this could be a viable option for you.

Detoxification Summary Report

Utilize our Detoxification Topic Summary Reports with your 23andMe or AncestryDNA genetic data to see which articles may be most relevant to you. These summaries are attempting to distill the complex information down into just a few words. Please see the linked articles for details and complete references. (Member’s article)