Category «Weight Loss»

Weight Loss: Optimizing your diet based on your genes

Diet gurus, talking heads on TV, government food pyramids, and your friend who lost 20 pounds… What do they all have in common?  They all know the perfect diet that will whip you into shape and make you feel good. If that diet doesn’t work for you?  Well, you must have been cheating. You didn’t …

Circadian Rhythms: Genes at the Core of Our Internal Clocks

Circadian rhythms are the natural biological rhythms that shape our biology.  Most people know about the master clock in our brain that keeps us on a wake-sleep cycle over 24 hours.  This is driven by our master “clock’ genes. It turns out that we also have circadian cycles (peripheral clocks) in most organs such as …

Detoxifying Phthalates:  Genes and Diet

There have been several recent studies about phthalates that have piqued my interest lately.  I decided that it was time to look into the science behind the stories and see if there really is anything to the scare-tactic type headlines about phthalates.  Below are my notes with links to studies.  I encourage you to check …

How our genes shape our gut microbiome and our weight

Several studies have come out recently showing that those who are overweight have a different gut microbiome composition than those who are lean.  There have also been interesting mouse studies showing that transplanting feces from obese mice into lean mice causes the lean mice to become obese.  A 2010 study that found that supplementation with the probiotic Lactobacillus …

Microbiome + genetics + emulsifiers = obesity

Recently, I listened to an interview (from 2015) of a scientist who did a study on emulsifiers and found that they can lead to low-grade inflammation in the gut, especially in mice with certain immune system genes knocked out. I find the interaction between our genes and our microbiome to be fascinating. Last summer I did …

Adiponectin levels, food choices, and genetics

Adiponectin, a hormone discovered in the 1990’s, is secreted by adipose (fat) tissue.  It is an anti-inflammatory protein, protective against the effects of low-grade inflammation that are associated with obesity. Although it is made in adipose tissue, those who have more fat tissue usually have lower adiponectin levels.  It is thought that the lower adiponectin levels (and …

BPA: Genetics and Detoxification

BPA, a chemical found in some plastics, has been linked to a variety of effects on people including obesity, insulin resistance, and epigenetic effects on the fetus.  It is everywhere in our food supply; 92% of people had BPA in their urine. [ref] My question today…  does BPA affect everyone the same way or do genetic …

Weight Loss Genetics – DHEA

Dehydroepiandrosterone (DHEA) is a natural steroid that tends to peak around age 25 and drop off rapidly in older people.This steroid is secreted by the adrenal cortex, and it is involved in a lipid (fat) catabolism.  Some studies have shown that DHEA reduces fat accumulation in mice fed a high-fat diet. A recent (June 2016) study …

Weight Loss Genetics – PLIN1

The perilipin 1 gene codes for the protein that covers lipid droplets in fat cells.  This coating protects the lipid droplets from the enzymes that break down fats for use as energy in the body.  Increased perilipin is associated with obesity.  Mice bred to be deficient in perilipin eat more than wild-type mice but gain half …

PPARG variants: saturated fat, obesity, and type 2 diabetes risk

The PPARG (peroxisome proliferator-activated receptor gamma) gene has been associated with obesity, metabolic syndrome, and risk for type-2 diabetes.  This gene is involved in the regulation of fatty acid storage and in glucose metabolism.  PPAR-gamma specifically is activated by omega-6 polyunsaturated fatty acids and regulates adipocyte differentiation. More specifically, PPARG is a nuclear transcription factor that …