Category «Weight Loss»

How our genes shape our gut microbiome and our weight

genes-gut-microbiome

Several studies have come out recently showing that those who are overweight have a different gut microbiome composition than those who are lean.  There have also been interesting mouse studies showing that transplanting feces from obese mice into lean mice causes the lean mice to become obese.  A 2010 study that found that supplementation with the probiotic Lactobacillus …

Microbiome, genetics, and emulsifiers = obesity

The connection between your genes, your gut health, and emulsifiers added to processed food.

Recently, I listened to an interview (from 2015) of a scientist who did a study on emulsifiers and found that they can lead to low grade inflammation in the gut, especially in mice with certain immune system genes knocked out.   Light bulbs started going off!  Time to dig into the published research to see if there …

Adiponectin levels, food choices, and genetics

food-choices

Adiponectin, a hormone discovered in the 1990’s, is secreted by adipose (fat) tissue.  It is an anti-inflammatory protein, protective against the effects of low-grade inflammation that are associated with obesity.  Although it is made in fat tissue, those who have more fat tissue usually have lower adiponectin levels.  It is thought that the lower adiponectin levels (and …

BPA: Genetics and Detoxification

Detox BPA

BPA, a chemical found in some plastics, has been linked to a variety of effects on people including: obesity, insulin resistance, and epigenetic effects on the fetus.  It is everywhere in our food supply; 92% of people had BPA in their urine. [ref] My question today…  does BPA affect everyone the same way or do genetic …

Weight Loss Genetics – DHEA

Weight Loss and Your Genes –

Dehydroepiandrosterone (DHEA) is a natural steroid that  tends to peak around age 25 and drop off rapidly in older people.This steroid is secreted by the adrenal cortex, and it is involved in a lipid (fat) catabolism.  Some studies have shown that DHEA reduces fat accumulation in mice fed a high fat diet. A recent (June 2016) …

Weight Loss Genetics – PLIN1

Weight Loss and Your Genes –

The perilipin 1 gene codes for the protein that covers lipid droplets in fat cells.  This coating protects the lipid droplets from the enzymes that break down fats for use as energy in the body.  Increased perilipin is associated with obesity.  Mice bred to be deficient in perilipin eat more than wild-type mice but gain half …

Weight Loss Genetics – PPARG polymorphisms

Weight Loss and Your Genes –

The PPARG (peroxisome proliferator-activated receptor gamma) gene has been associated with obesity, metabolic syndrome and risk for type-2 diabetes.  This gene is involved in the regulation of fatty acid storage and in glucose metabolism.  PPAR-gamma specifically is activated by omega-6 polyunsaturated fatty acids and regulates adipocyte differentiation. The most commonly studied polymorphisms, rs1801282, is thought …

Weight Loss Genetics – TCFL72 polymorphisms

Weight Loss and Your Genes –

TCF7L2 – transcription factor 7-like 2 gene – is involved in beta cells in the pancreas which produce insulin as well as being involved in adipocytes (fat cells) and metabolic syndrome.  It is a part of the Wnt signaling pathway, which passes signals into cells through surface receptors. Polymorphisms in TCFL2 are tied to type-2 diabetes, obesity, …

Weight Loss Genetics – Circadian Rhythm genes

Circadian rhythms are the natural biological rhythms that shape our biology.  Most people know about the master clock in our brain that keeps us on a wake-sleep cycle over 24hours.  It turns out that we have “clocks” in most organs such as the liver, pancreas, and fat cells.  Our microbiome in our gut also has …

Weight Loss Genetics – Leptin Receptor Polymorphisms

Leptin is a hormone that is well known in the weight-loss-dogma / diet-guru arena.  The hormone, discovered in 1994, is produced in fat cells and signals to the hypothalamus in the brain that you have enough stored energy. When you go on a low calorie diet to lose weight, leptin increases to tell your brain …