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MTHFR Mutation: What is it? How to check your raw data.

The MTHFR gene is important for how your body utilizes folate (vitamin B9) for creating neurotransmitters, detoxifying toxicants, and maintaining a healthy heart. Check your 23andMe or AncestryDNA data for the MTHFR C677T and A1298C variants.

MTHFR: Going Beyond C677T and A1298C

The MTHFR C677T and A1298C variants get a lot of press, but they do not give the whole picture of the MTHFR gene. Additional variants are impacting the functionality of the enzyme.

MTHFR, depression, anxiety, symptoms and treatment

We are all genetically unique, and a common genetic variant in the MTHFR gene causes some people to be more susceptible to having low folate levels. This article explains the research linking MTHFR variants, folate, and depression — and gives you information on how diet or supplements may help.

MTHFR and Migraines

The MTHFR C677T variant increases the risk of migraines. Learn how to check your genetic data and how to mitigate the risk.

Folate Optimization: MTHFR and Fertility

MTHFR variants affect the conversion of folate into the active form. Learn how this can affect you if you are trying to get pregnant.

Blood pressure, MTHFR, and riboflavin

The common MTHFR C677T variant increases the relative risk of high blood pressure. Learn how to add more Riboflavin (B2) into your diet to reduce risk.

Vaccines and the MTHFR mutation

A lot of people use the MTHFR variants as a reason not to vaccinate their kids. Is there any science to back this up? See what the research says.

What happens if I have MTHFR?

Wondering what MTHFR is all about? Learn what the research says about it and how to check your own raw data file.


Snips about SNPs: MTHFR

A quick way to check your 23 and Me or AncestryDNA data for the MTHFR mutation. Learn whether you should add more folate to your diet.

Dads matter: MTHFR variants in fathers affect miscarriage risk

Dads matter – in conception, pregnancy, and throughout life. It is easy to see how prospective moms need to clean up their diets, exercise, and sleep well before getting pregnant, but recent studies show that a dad’s MTHFR variants also affect infertility and miscarriage risk.

Riboflavin (Vitamin B2), MTHFR, and Genetics

Riboflavin, or vitamin B2, is an essential cofactor for many biological pathways. Learn how to check your genetic raw data to see if you may need more riboflavin.

News and Research: MTHFR and dietary folate

Study: Food Intervention with Folate Reduces TNF-α and Interleukin Levels in Overweight and Obese Women with the MTHFR C677T Polymorphism: A Randomized Trial Nutrients, Feb 2020 Overivew: This randomized controlled trial investigated the effects of increased dietary folate via vegetable consumption in overweight Brazilian women with the MTHFR C677T variant.  (Check your MTHFR variant here) The researchers looked at inflammatory levels measured as homocysteine, TNF-α, IL-1B, and IL-6. The study participants were divided into two groups, each consuming 300 g of vegetables per day for 8 weeks. Group I at vegetables containing 95µg of folate, and Group II at vegetables containing 191 µg of folate each day. In women with two copies of the MTHFR C677T variant (A/A for 23andMe data), the increased dietary folate reduced their homocysteine, TNF-α, IL-6, and IL-1β levels.   For women with one copy of the variant, the change in those inflammatory markers was not significant. My take away:  This study is interesting because it shows that dietary increases in folate are enough to decrease inflammatory markers in women with MTHFR 677TT.  I’ve always thought of … Read more

Folate-rich recipes for MTHFR

Getting enough folate in your diet? We’ve collected some simple nutritional tools and recipes to get you on track.

Histamine Intolerance, MTHFR, and the Methylation Cycle

Genetics plays a role in how well your body breaks down histamine. Histamine that is out of balance with the body’s ability to break it down can cause symptoms that are collectively known as histamine intolerance. Discover how to check your genes that are involved with histamine levels.

‘MTHFR Coffee’ with Eggs and Kale for Breakfast

Spurred on by a podcast, I share a great breakfast that supports the methylation cycle. Gelatin is an excellent source of glycine, an amino acid that is often short-changed in our modern diet. You can even add it to your morning coffee.

Dopamine Synthesis SNPs: Genes, lifestyle, diet, and dopamine optimization

Key takeaways: ~ Dopamine synthesis begins with the conversion of tyrosine to l-DOPA, which is then converted to dopamine. ~ The key enzymes in this synthesis are TH (tyrosine hydroxylase) and DDC. ~ Genetic variants in these genes, along with lifestyle, diet, and other environmental factors, affect dopamine levels. ~ Testing can show you where you’re at, and supplements or dietary changes can help optimize dopamine levels. What does dopamine do? Dopamine is a neurotransmitter that is essential for many brain functions and behaviors. It is the neurotransmitter that makes you feel good — pleasure, satisfaction, motivation… Dopamine is part of the brain’s reward system, which reinforces pleasurable experiences and motivates you to do them again. In the part of the brain that controls movement, dopamine helps regulate motor control of voluntary muscles and coordination. Dopamine is involved in attention, helping you focus and filter out irrelevant information. It helps form new memories, reinforces learning, and plays a role in evaluating outcomes and choosing appropriate actions. Dopamine helps regulate emotions, especially positive feelings such as happiness and pleasure. Too little … Read more