The MTHFR gene is important for how your body utilizes folate (vitamin B9) for creating neurotransmitters, detoxifying toxicants, and maintaining a healthy heart. Check your 23andMe or AncestryDNA data for the MTHFR C677T and A1298C variants.
The MTHFR C677T and A1298C variants get a lot of press, but they do not give the whole picture of the MTHFR gene. Additional variants are impacting the functionality of the enzyme.
We are all genetically unique, and a common genetic variant in the MTHFR gene causes some people to be more susceptible to having low folate levels. This article explains the research linking MTHFR variants, folate, and depression — and gives you information on how diet or supplements may help.
The MTHFR C677T variant increases the risk of migraines. Learn how to check your genetic data and how to mitigate the risk.
MTHFR variants affect the conversion of folate into the active form. Learn how this can affect you if you are trying to get pregnant.
The common MTHFR C677T variant increases the relative risk of high blood pressure. Learn how to add more Riboflavin (B2) into your diet to reduce risk.
Is the MTHFR mutation is a reason not to get the covid vaccine? Learn more with a look into the research behind MTHFR mutations and vaccines.
A lot of people use the MTHFR variants as a reason not to vaccinate their kids. Is there any science to back this up? See what the research says.
Wondering what MTHFR is all about? Learn what the research says about it and how to check your own raw data file.
Methylfolate may be a better option than folic acid if you have certain genetic variants in the MTHFR or DHFR genes.
This new study shows that people who carry the MTHFR 677 A/A genotype are at a 42% increased relative risk of high blood pressure throughout adulthood.
A quick way to check your 23 and Me or AncestryDNA data for the MTHFR mutation. Learn whether you should add more folate to your diet.
Dads matter – in conception, pregnancy, and throughout life. It is easy to see how prospective moms need to clean up their diets, exercise, and sleep well before getting pregnant, but recent studies show that a dad’s MTHFR variants also affect infertility and miscarriage risk.
Riboflavin, or vitamin B2, is an essential cofactor for many biological pathways. Learn how to check your genetic raw data to see if you may need more riboflavin.
Study: Food Intervention with Folate Reduces TNF-α and Interleukin Levels in Overweight and Obese Women with the MTHFR C677T Polymorphism: A Randomized Trial Nutrients, Feb 2020 Overivew: This randomized controlled trial investigated the effects of increased dietary folate via vegetable consumption in overweight Brazilian women with the MTHFR C677T variant. (Check your MTHFR variant here) The researchers looked at inflammatory levels measured as homocysteine, TNF-α, IL-1B, and IL-6. The study participants were divided into two groups, each consuming 300 g of vegetables per day for 8 weeks. Group I at vegetables containing 95µg of folate, and Group II at vegetables containing 191 µg of folate each day. In women with two copies of the MTHFR C677T variant (A/A for 23andMe data), the increased dietary folate reduced their homocysteine, TNF-α, IL-6, and IL-1β levels. For women with one copy of the variant, the change in those inflammatory markers was not significant. My take away: This study is interesting because it shows that dietary increases in folate are enough to decrease inflammatory markers in women with MTHFR 677TT. I’ve always thought of … Read more
Getting enough folate in your diet? We’ve collected some simple nutritional tools and recipes to get you on track.
Genetics plays a role in how well your body breaks down histamine. Histamine that is out of balance with the body’s ability to break it down can cause symptoms that are collectively known as histamine intolerance. Discover how to check your genes that are involved with histamine levels.
Spurred on by a podcast, I share a great breakfast that supports the methylation cycle. Gelatin is an excellent source of glycine, an amino acid that is often short-changed in our modern diet. You can even add it to your morning coffee.
Two key enzymes are needed for dopamine synthesis. Genetics, diet, and lifestyle can influence your dopamine production.