Depression genes

Depression, genetics, and mitochondrial function

How does mitochondrial dysfunction relate to major depressive disorder? Learn about the causes of mitochondrial dysfunction as well as genetic variants that link the risk of depression to the mitochondria.

Circadian Rhythm Disruption Causes Depression

For some people, circadian disruption can be chronic – and at the heart of depression or mood disorders. Genetic variants play a role in this susceptibility. Fortunately, there are solutions that may help. ​

MTHFR and Depression

We are all genetically unique, and a common genetic variant in the MTHFR gene causes some people to be more susceptible to having low folate levels. This article explains the research linking MTHFR variants, folate, and depression — and gives you information on how diet or supplements may help.

mood disorders

Bipolar Disorder, Depression, and Circadian Clock Genes

New research shows that depression and bipolar disorder are linked to changes or disruption in circadian genes. Some people carry genetic variants in the circadian genes that make them more susceptible to circadian disruption.

BDNF variants

BDNF: introversion, stress resilience, cognition, and depression

Low levels of BDNF (Brain-derived neurotrophic factor) are linked to introversion, stress resilience, cognition, and depression levels. Discover ways to increase your BDNF levels and mitigate the problems associated with the BDNF gene variants. (Member’s article)

GABA: Genetics, Anxiety, and Immune Response

GABA (gamma-Aminobuyteric acid) is a neurotransmitter that acts to block or inhibit a neuron from firing. It is an essential way that the brain regulates impulses, and low GABA levels are linked with several conditions, including anxiety and PTSD.

conversion of tryptophan to kynurenine or serotonin

Tryptophan Pathways: Kynurenine, Serotonin, and Melatonin

Tryptophan is an amino acid that the body uses to make serotonin and melatonin. Genetic variants can impact the amount of tryptophan that is used for serotonin. This can influence mood, sleep, neurotransmitters, and immune response.

Glycine and Slow Wave Sleep

Sleep quality is essential for good health and our genetics play a role in how much slow wave sleep we naturally get.

Case Examples: Nutrigenomics

Wondering what to look for on the vitamins and foods cheat sheet? Here are a few examples of how nutrigenomics (nutrition + genomics) can impact someone.

Alopecia Areata: Reasons for Rapid Hair Loss

Alopecia areata is an autoimmune-like disorder in which the immune system attacks the hair follicle. Learn about the triggers of alopecia areata, why the hair falls out, genetic variants that increase susceptibility, and possible treatment options.

Anxiety: Genetics and personalized solutions

This article covers genetic variants related to anxiety disorders. Genetic variants combine with environmental factors (nutrition, sleep, relationships, etc) when it comes to anxiety. There is not a single “anxiety gene”. Instead, there are many genes that can be involved – and many genetic pathways to target for solutions.

quercetin

Quercetin: Scientific studies + genetic connections

Quercetin is a natural flavonoid acting as both an antioxidant and anti-inflammatory. This article focuses on the results of clinical trials involving quercetin and links to specific genetic topics. Using your genetic data, you can make a more informed decision on whether quercetin is worth trying.