Fluoride: Health Effects And Detoxification Genes
Discover the pros and cons of fluoride for dental health and overall wellness, its sources, toxicity levels, and how genetics influence fluoride sensitivity.
Detoxification & Medication Metabolism
We break down toxins and medications using specific detoxification pathways and enzymes. Genetic variants (SNPs) in detoxification genes can cause some people to be more sensitive to environmental toxins or medications. The goal here is to understand which phase 1 and phase II detoxification genes may cause problems for you in conjunction with exposure to toxicants, heavy metals, or medications.
Where to start?
- Start with the Phase I and Phase II Detoxification Overview
- Interesting: Are you a fast or slow metabolizer of caffeine (CYP1A2 gene)?
- Reacting to everything? Check out multiple chemical sensitivity.
- Worried about endocrine disruptors like phthalates or BPA?
Members: Start with the Detoxification Topic Summary Report for a quick overview of all your genetic variants related to how you detox or metabolize different compounds.
Latest articles on Detoxification & Metabolism of Medications:
NAT1 and NAT2: N-acetyltransferases and Phase II Detoxification
N-acetyltransferase is a phase II detoxification enzyme that gets rid of several types of toxicants. It helps your body eliminate aromatic amines, drugs, cigarette smoke, and carcinogens.
CYP2B6: Genetic Variants That Interact with Medications
The CYP2B6 enzyme is part of the body’s first line of defense in detoxifying and breaking down certain and important for metabolizing several medications. Genetic variants of this enzyme can either speed up or slow down its function.
Mercury Detoxification: Genomics and Solutions
What are the physiological effects of mercury and how does the body eliminates it? Discover how genetic variants play a role in how quickly you excrete mercury.
Antibiotics: Genetics and Antibiotic Reactions
Genetics plays a role in the susceptibility to antibiotic allergies. Learn which genetic variants increase your risk.
Glucuronidation: UGT Genetic Variants, Detoxification, and Hormone Balance
The UGT family of enzymes is responsible for an important part of phase II detoxification. This article explains what the UGT enzymes do in the body, how your genes impact this part of detoxification, and lifestyle factors that can increase or decrease this detox process.
CYP2C8 Pharmacogenetics: Ibuprofen, NSAID Risk, and Arachidonic Acid
CYP2C8 pharmacogenomics: see how variants in this detox gene change the metabolism of ibuprofen and other drugs, influence bleeding risk, and interact with CYP2C9 and supplements.
CYP1A2 Gene: Fast or Slow Caffeine Metabolizer and More
The CYP1A2 gene breaks down caffeine, melatonin, several major prescription drugs, and interacts with smoking. Learn how your genes influence caffeine metabolism and more.
CYP2D6: Medication Interactions, Natural Inhibitors, and Anxiety Traits
The CYP2D6 enzyme is responsible for metabolizing about 25% of commonly used medications. There are several fairly common genetic variants in CYP2D6 that affect how quickly you will break down a drug.
CYP2E1: Breaking down alcohol and more
The CYP2E1 enzyme is part of the phase I detoxification system. Discover how variants might affect your alcohol metabolism and more.
GSTM1: GST Enzymes and Glutathione for Environmental Toxins
Exposure to many different man-made chemical compounds occurs every day, and our exposure to new toxicants exceeds what our ancestors experienced. Several common GST variants decrease the function of the GST enzymes.
SOD1 Gene: Your Antioxidant Defense System
Our body has built-in antioxidants that fight against cellular stress. The superoxide dismutase enzyme fights against oxidative stress in your cells.
CYP3A4 Gene: Impacting Prescription Drugs, Vitamin D, and Grapefruits
The CYP3A family of genes is involved in metabolizing about half of the drugs on the market today. Check your genes to see if you carry variants that impact the speed at which you metabolize medications.
CYP2A6: Breaking down nicotine and other medications
CYP2A6 gene variants shape how fast you break down nicotine and key medications, influencing smoking habits, chemo response, and drug side effects.
CYP1A1: Detoxifying Cigarette Smoke and Estrogen
This phase I detoxification gene is important in the breakdown of the hydrocarbons produced in smoke and air pollution. It also affects the metabolism of estrogen.
Should you eat organic? Detoxifying Neonicotinoids
Is buying organic worth the extra cost? Pesticides that are sprayed on conventionally grown foods affect people differently. Some people carry genetic variants that decrease their ability to detoxify specific pesticides, others may be more resilient. This is Part One in a multipart series on pesticide detoxification. (Member’s article)
Tamiflu: Genetic Reasons it May not Work for You
Genetic variants impact how well the flu antiviral medication, Tamiflu, works for an individual. Learn how your genes impact this medication.
Allergy Medicine: Why Fexofenadine Works Better for Some People
Ever wonder why a certain medication may work great for a friend and do nothing for you? One reason could be the genes involved in transporting the medication into and out of your cells. This article looks at the research studies on fexofenadine and the Multidrug Resistance Protein variants.
Alcohol Metabolism: ALDH2 and ADH1B Genes
Wondering why you don’t react the same way to alcohol as your friends do? Some people metabolize alcohol faster leaving a build-up of acetaldehyde. Learn more about why this can be a health problem for some.
Should you eat organic? Genes that Influence Pyrethroid Metabolism
Pyrethroids are commonly found in household insecticides. Genetic variants can impact how fast or slowly you break down the chemical. Learn more about this chemical in part 3 of a pesticide series.
Should you eat organic? Detoxifying Organophosphates
Is buying organic worth the extra cost? There isn’t a one-size-fits-all answer to that question. Pesticides that are sprayed on conventionally grown foods affect people differently. Some people carry genetic variants that decrease their ability to detoxify specific pesticides, others may be more resilient. This is Part Two in a multipart series on pesticide detoxification.
Gulf War Illness: Genetic Susceptibility and Current Research
Many genetic variants have been studied for Gulf War Illness. Take a look into the research behind the illness and discover some possible solutions to help with symptoms.
Detoxification Summary Report
Utilize our Detoxification Topic Summary Reports with your 23andMe or AncestryDNA genetic data to see which articles may be most relevant to you. These summaries are attempting to distill the complex information down into just a few words. Please see the linked articles for details and complete references. (Member’s article)