Detoxification & Metabolism of Medications

Genetic variants about in the enzymes that break down drugs and toxins. These genetic differences are why some medications don’t work well for certain people. Our reactions to toxicants, such as pesticides, also rely on our genes.

Explanation of Phase I and Phase II Detoxification

Member’s: Check out the Detoxification Topic Summary Report for a quick overview of all your genetic variants related to how you detox or metabolize different compounds.

CYP2D6 gene and medication reactions

The CYP2D6 enzyme is responsible for metabolizing about 25% of commonly used medications. There are several fairly common genetic variants in CYP2D6 that affect how quickly you will break down a drug.

Caffeine Metabolism and Your Genes

Caffeine remains the most popular ‘drug’ of choice for a large percentage of the population. Genetics determines how quickly your body processes and eliminates caffeine and whether it is likely to make you jittery or anxious.

Opioid Receptors: Turning Off Pain

Genetic variants in the ORPM1 gene impact both the amount of pain someone experiences and their response to opioid drugs. These variants are also important in susceptibility to opiate addiction. (Member’s article)

CYP3A4 Gene: Impacting Prescription Drugs

The CYP3A family of genes is involved in metabolizing about half of the drugs on the market today. Check your genes to see if you carry variants that impact the speed at which you metabolize medications.