Search Results for: MTHFR
MTHFR Gene Explained: C677T and A1298C Variants, Testing, and Solutions
The MTHFR gene is important for how your body utilizes folate (vitamin B9) for creating neurotransmitters, detoxifying toxicants, and maintaining a healthy heart. It is a key gene in the methylation cycle.
DHFR and MTHFR: Folic Acid Metabolism
Methylfolate and folic acid—what’s the difference? Learn how DHFR and MTHFR variants affect folic acid metabolism, unmetabolized folic acid, cancer and autism risk, BH4 recycling, and how to choose the right supplement for your genes.
MTHFR C677T Genotype
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Riboflavin (Vitamin B2), MTHFR, and Deficiency Symptoms
Riboflavin, or vitamin B2, is an essential cofactor for many biological pathways. Learn how to check your genetic raw data to see if you may need more riboflavin.
Folate Optimization: MTHFR and Fertility
MTHFR variants affect the conversion of folate into the active form. Learn how this can affect you if you are trying to get pregnant.
Blood Pressure, MTHFR, and Riboflavin
The common MTHFR C677T variant increases the relative risk of high blood pressure. Learn how to add more Riboflavin (B2) into your diet to reduce risk.
Understanding MTHFR Test Results
Unraveling MTHFR: A Comprehensive Guide The human body is a complex system, and understanding its intricacies can often seem like a daunting task. One such complexity lies in our genes, specifically the MTHFR gene. This gene, and the enzyme it produces, plays a crucial role in our health. However, mutations … Read more
Can you get the COVID vaccine if you have MTHFR?
Is the MTHFR mutation is a reason not to get the covid vaccine? Learn more with a look into the research behind MTHFR mutations and vaccines.
MTHFR: Going Beyond C677T and A1298C
The MTHFR C677T and A1298C variants get a lot of press, but they do not give the whole picture of the MTHFR gene. Additional variants are impacting the functionality of the enzyme.
MTHFR, Depression, Anxiety, Symptoms and Treatment
We are all genetically unique, and a common genetic variant in the MTHFR gene causes some people to be more susceptible to having low folate levels. This article explains the research linking MTHFR variants, folate, and depression — and gives you information on how diet or supplements may help.
Vaccines and the MTHFR mutation
This article covers what the research shows about folate metabolism, MTHFR, and immune response. See what the research says.
What happens if I have MTHFR?
Wondering what MTHFR is all about? Learn what the research says about it and how to check your own raw data file.
MTHFR and Migraines
The MTHFR C677T variant increases the risk of migraines. Learn how to check your genetic data and how to mitigate the risk.
MTHFR: How to check your data for C677T and A1298C
Key takeaways: The MTHFR enzyme converts folate (vitamin B9) to its active form, 5-MTHF. Folate is used to create methyl groups, which cells use to synthesize neurotransmitters, detoxify toxicants, methylate DNA, and maintain a healthy heart. The common MTHFR C677T and A1298C variants lower enzyme function (up to ~70–80% for … Read more
News and Research: MTHFR C677T, Riboflavin, High blood pressure
This new study shows that people who carry the MTHFR 677 A/A genotype are at a 42% increased relative risk of high blood pressure throughout adulthood.
Folate-rich recipes for MTHFR
Getting enough folate in your diet? We’ve collected some simple nutritional tools and recipes to get you on track.
Histamine Intolerance, MTHFR, and the Methylation Cycle
Genetics plays a role in how well your body breaks down histamine. Histamine that is out of balance with the body’s ability to break it down can cause symptoms that are collectively known as histamine intolerance. Discover how to check your genes that are involved with histamine levels.
Dads Matter: MTHFR Variants in Fathers Affect Miscarriage Risk
Dads matter – in conception, pregnancy, and throughout life. It is easy to see how prospective moms need to clean up their diets, exercise, and sleep well before getting pregnant, but recent studies show that a dad’s MTHFR variants also affect infertility and miscarriage risk.
Riboflavin (Vitamin B2): MTHFR and FMO3 SNPs
Riboflavin (Vitamin B2) is a water-soluble vitamin cofactor for many enzymes in the body. However, several genetic variants can cause an increased need for riboflavin.
Methylation Cycle
Key takeaways: The methylation cycle is one of the most fundamental biochemical pathways in the body — running billions of times per day in nearly every cell. It provides methyl groups (one carbon atom bonded to three hydrogens) to DNA, proteins, and small molecules. These methyl groups influence everything from … Read more
What Can You Do With Your Genetic Raw Data to Improve Your Health?
If you’ve taken a DNA test through 23andMe, AncestryDNA, or MyHeritage, you already have access to something incredibly valuable: your raw genetic data. This is a data file that you can download — it is your data to use and keep. And when you combine it with current genetics research, … Read more
Longevity Lifehacks Articles
Articles on longevity science (Longevity Lifehacks Substack) with connections to personalized health and genetics.
Gene Function Explorer
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2026 Guide: Tools for Analyzing Your Genetic Raw Data
Your genetic raw data file is packed with insights that go beyond the ancestry and traits reports. By exploring your raw genetic data, you can discover information about nutrition, health and disease risk, supplement responses, nutrient interactions, methylation cycle pathways, detoxification pathways, and much more. But with fly-by-night genetic report … Read more