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Understanding MTHFR Test Results

Unraveling MTHFR: A Comprehensive Guide The human body is a complex system, and understanding its intricacies can often seem like a daunting task. One such complexity lies in our genes, specifically the MTHFR gene. This gene, and the enzyme it produces, plays a crucial role in our health. However, mutations in this gene can lead to a variety of health issues. In this article, we will delve into the world of MTHFR, exploring its function, the implications of its mutations, and how to manage these mutations effectively. What is MTHFR? MTHFR stands for Methylenetetrahydrofolate Reductase. It is a key regulatory enzyme in the metabolism of folate and also refers to a specific gene that plays a major role in the body’s methylation process. Both the enzyme and the gene share the same name, MTHFR. When people refer to “MTHFR,” they’re typically discussing one of the two common MTHFR gene mutations that cause the enzyme to become less effective in the body. These mutations can lead to imperfect folate coenzymes, which do not function properly, affecting various downstream processes such as … Read more

Riboflavin (Vitamin B2), MTHFR, and Genetics

Riboflavin, or vitamin B2, is an essential cofactor for many biological pathways. Learn how to check your genetic raw data to see if you may need more riboflavin.

Folate Optimization: MTHFR and Fertility

MTHFR variants affect the conversion of folate into the active form. Learn how this can affect you if you are trying to get pregnant.

Blood pressure, MTHFR, and riboflavin

The common MTHFR C677T variant increases the relative risk of high blood pressure. Learn how to add more Riboflavin (B2) into your diet to reduce risk.

MTHFR Mutation: What is it? How to check your raw data.

The MTHFR gene is important for how your body utilizes folate (vitamin B9) for creating neurotransmitters, detoxifying toxicants, and maintaining a healthy heart. Check your 23andMe or AncestryDNA data for the MTHFR C677T and A1298C variants.

MTHFR: Going Beyond C677T and A1298C

The MTHFR C677T and A1298C variants get a lot of press, but they do not give the whole picture of the MTHFR gene. Additional variants are impacting the functionality of the enzyme.

MTHFR, depression, anxiety, symptoms and treatment

We are all genetically unique, and a common genetic variant in the MTHFR gene causes some people to be more susceptible to having low folate levels. This article explains the research linking MTHFR variants, folate, and depression — and gives you information on how diet or supplements may help.

Vaccines and the MTHFR mutation

A lot of people use the MTHFR variants as a reason not to vaccinate their kids. Is there any science to back this up? See what the research says.

What happens if I have MTHFR?

Wondering what MTHFR is all about? Learn what the research says about it and how to check your own raw data file.

MTHFR and Migraines

The MTHFR C677T variant increases the risk of migraines. Learn how to check your genetic data and how to mitigate the risk.

News and Research: MTHFR and dietary folate

Study: Food Intervention with Folate Reduces TNF-α and Interleukin Levels in Overweight and Obese Women with the MTHFR C677T Polymorphism: A Randomized Trial Nutrients, Feb 2020 Overivew: This randomized controlled trial investigated the effects of increased dietary folate via vegetable consumption in overweight Brazilian women with the MTHFR C677T variant.  (Check your MTHFR variant here) The researchers looked at inflammatory levels measured as homocysteine, TNF-α, IL-1B, and IL-6. The study participants were divided into two groups, each consuming 300 g of vegetables per day for 8 weeks. Group I at vegetables containing 95µg of folate, and Group II at vegetables containing 191 µg of folate each day. In women with two copies of the MTHFR C677T variant (A/A for 23andMe data), the increased dietary folate reduced their homocysteine, TNF-α, IL-6, and IL-1β levels.   For women with one copy of the variant, the change in those inflammatory markers was not significant. My take away:  This study is interesting because it shows that dietary increases in folate are enough to decrease inflammatory markers in women with MTHFR 677TT.  I’ve always thought of … Read more

how to check your 23andMe data for MTHFR mutation

MTHFR: How to check your data for C677T and A1298C

Key takeaways: ~ The MTHFR gene impacts how your body utilizes folate (vitamin B9) for creating neurotransmitters, detoxifying toxicants, and maintaining a healthy heart. ~ Genetic variants can impact how well this gene works. ~ Optimizing diet and supplements related to methylation may impact several aspects of wellness. Check your raw data for C677T, A1298C, and more This article shows you what to check in your raw data, then explains the scientific research on the MTHFR variants. At the end of the article, you will find solid, evidence-based lifestyle solutions for optimizing the MTHFR variants. Frankly, there is a lot of misinformation on the internet about the MTHFR gene mutations, so I will explain the peer-reviewed research studies here. I’ll clearly explain how to optimize your diet (or add in supplements) if you carry MTHFR genetic variants. MTHFR Gene Mutations Genotype Report: Let’s put the rest of this article into context by checking your two more common MTHFR variants first. (I’ll include other MTHFR variants later in the article). You don’t need to do specific genetic testing or buy health … Read more

Folate-rich recipes for MTHFR

Getting enough folate in your diet? We’ve collected some simple nutritional tools and recipes to get you on track.

Histamine Intolerance, MTHFR, and the Methylation Cycle

Genetics plays a role in how well your body breaks down histamine. Histamine that is out of balance with the body’s ability to break it down can cause symptoms that are collectively known as histamine intolerance. Discover how to check your genes that are involved with histamine levels.


Snips about SNPs: MTHFR

A quick way to check your 23 and Me or AncestryDNA data for the MTHFR mutation. Learn whether you should add more folate to your diet.

Dads matter: MTHFR variants in fathers affect miscarriage risk

Dads matter – in conception, pregnancy, and throughout life. It is easy to see how prospective moms need to clean up their diets, exercise, and sleep well before getting pregnant, but recent studies show that a dad’s MTHFR variants also affect infertility and miscarriage risk.