Circadian Rhythm Disruption as a Root Cause of Depression
Research shows circadian clock gene variants influence depression risk. Learn how light exposure, genetics, and the molecular clock shape mental health.
Search Results for: depression
Inflammation as a Cause of Depression and Anxiety
Discover why inflammation causes depression and how your genetic variants in inflammatory genes may play a role in depression or anxiety.
Reelin – Long Covid, Depression, and Alzheimer’s
Reelin is a key glycoprotein involved in brain development, cognition, and neurodegenerative diseases like Alzheimer’s, schizophrenia, autism, and cardiovascular health.
Underlying Cause(s) of Depression: Leveraging Your Genetic Data
Depression can have multiple physiological causes. This article ties together 9 separate articles on depression to simply your genetic search.
Depression, Genetics, and Mitochondrial Function
How does mitochondrial dysfunction relate to major depressive disorder? Learn about the causes of mitochondrial dysfunction as well as genetic variants that link the risk of depression to the mitochondria.
MTHFR, Depression, Anxiety, Symptoms and Treatment
We are all genetically unique, and a common genetic variant in the MTHFR gene causes some people to be more susceptible to having low folate levels. This article explains the research linking MTHFR variants, folate, and depression — and gives you information on how diet or supplements may help.
Bipolar Disorder, Depression, and Circadian Clock Genes
New research shows that depression and bipolar disorder are linked to changes or disruption in circadian genes. Some people carry genetic variants in the circadian genes that make them more susceptible to circadian disruption.
Methylation Cycle
Key takeaways: This page is a hub for all Genetic Lifehacks articles and member tools related to the methylation cycle, organized to help you learn step‑by‑step. Start here if you’re new: Members’ tools for methylation: Methylation Cycle Topic Summary Prioritize which articles apply to your genotypes by using the summary … Read more
Blood-Brain Barrier Genes: SNPs, Leaky BBB Risks & Solutions
Genetic variants can increase susceptibility to blood-brain barrier (BBB) dysfunction. This can increase the risk of Alzheimer’s, ADHD, and mood disorders.
What Can You Do With Your Genetic Raw Data to Improve Your Health?
If you’ve taken a DNA test through 23andMe, AncestryDNA, or MyHeritage, you already have access to something incredibly valuable: your raw genetic data. This is a data file that you can download — it is your data to use and keep. And when you combine it with current genetics research, … Read more
Longevity Lifehacks Articles
Articles on longevity science (Longevity Lifehacks Substack) with connections to personalized health and genetics.
TRPV1 Gene: Receptor for Spicy Foods, Sensing Cold, and CBD Oil
Learn how the TRPV1 gene shapes your reaction to spicy foods, pain, temperature, neuroinflammation and CBD oil, plus see how your genetic variants may affect tolerance and health.
Candida Biology, Pathogenesis, and Genetic Susceptibility
Learn why genetic variants in IL‑17, TLRs, dectin‑1, MBL, FUT2, and STAT1 can make some people much more susceptible to chronic or severe Candida infections.
GLP-1 Genetics: How Genes Affect Appetite, Semaglutide, and Tirzepatide Response
Genes affect how well semaglutide (Ozympic) and tirzepatide work. Check your GLP-1 receptor gene variants linked to weight loss response. Genotype report included.
MMUT Gene Variants & Methylmalonic Acid: B12 Status & Genetics
MMUT gene variants affect how your body uses B12 for mitochondrial energy. Learn how MMA testing reveals intracellular B12 deficiency and which form of B12 can help.
2026 Guide: Tools for Analyzing Your Genetic Raw Data
Your genetic raw data file is packed with insights that go beyond the ancestry and traits reports. By exploring your raw genetic data, you can discover information about nutrition, health and disease risk, supplement responses, nutrient interactions, methylation cycle pathways, detoxification pathways, and much more. But with fly-by-night genetic report … Read more
ME/CFS and Genetics: Chronic Fatigue Syndrome Genes, Immune Pathways, and Natural Solutions
Genetic variants in immune, mitochondrial, and inflammatory pathways (NK cells, NLRP3, interferon, complement, TRP channels) increase ME/CFS susceptibility. Check your genes and explore research-backed solutions.
Borderline Personality Disorder: How Genes, Trauma, and Inflammation Interact
Genetics, epigenetics, and childhood trauma all contribute to BPD. Understand the neurotransmitter disruptions, inflammatory markers, and circadian rhythm issues—with solutions that work.
TNF-alpha: Inflammation, Chronic Diseases, and Genetic Susceptibility
TNF-alpha is a key inflammatory cytokine linked to autoimmune, cardiovascular, mood, and neurodegenerative diseases. Learn how TNF gene variants affect your risk and potential natural TNF inhibitors.
Nicotinamide Riboside and NMN: Boosting NAD+ in Aging with Supplements
Explore the research about how nicotinamide riboside (NR) and NMN are being used to reverse aging. Learn about how your genes naturally affect your NAD+ levels and how this interacts with the aging process.
Raynaud’s: Causes, Symptoms, and Genetics
Do your fingertips turn white and blue when cold? Discover the causes and symptoms of Raynaud’s syndrome and your genetic susceptibility.
Trigger Points, Myofascial Pain Syndrome, and Underlying Causes
Trigger points are hyperirritated knots in the muscle and fascia that can refer pain to a nearby region of the body.
Dry Eyes: Using Genetic Data to Find the Right Solutions
Use your genetic data to understand the root causes of dry eyes, from immune response to meibomian glands, and explore research-backed options to relieve symptoms.