Histamine Intolerance Genetics: DAO & HNMT Genes, Supplements
Genetic variants in DAO and HNMT genes affect histamine breakdown. Check your AOC1, HNMT, and HDC genotype. Low-histamine diet, DAO supplements, and more.
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ABCB1 (P-glycoprotein): Response to Medications, HRT, and Environmental Toxins
ABCB1 encodes P-glycoprotein, a transporter that removes toxins – and medications – from the body. Genetic variants in the ABCB1 gene can affect how well a medication works for you.
Inflammation as a Cause of Depression and Anxiety
Discover why inflammation causes depression and how your genetic variants in inflammatory genes may play a role in depression or anxiety.
NLRP3: Genetic Variants that Increase Chronic Inflammation
Explore NLRP3 inflammasome genetics: How variants drive chronic inflammation in Alzheimer’s, diabetes, and autoimmune diseases. Discover triggers, health risks, and lifehacks like zinc & vitamin D to modulate it.
Mast Cells: MCAS, Genetics, and Solutions
Mast cells are essential to your innate immune system, defending against pathogens and allergens. For some people, mast cells can be triggered too easily, giving allergy-like responses to lots of different substances.
Building Up Iron: Hemochromatosis Mutations
A couple of common mutations can cause you to build up iron, leading to iron overload or hemochromatosis. It is one genetic disease where knowledge is really powerful – you can completely prevent hemochromatosis through blood donations.
Fatty Liver Disease: Genetics and Reasons for NAFLD, MAFLD
Non-alcoholic fatty liver disease (NAFLD) can be caused by genetic susceptibility, diet, and lifestyle factors. The good news is that fatty liver disease is reversible.
Flu Season: Genetics and Your Immune Response
Are you more genetically susceptible to the flu? Learn how your genes play a role and discover research-backed natural options to beat the flu.
Testosterone: Genetic Variants that Impact Testosterone Levels
While diet and lifestyle play a role in testosterone levels, in males, there is a strong genetic component as well. Check out your genes to see if they are playing a role in your low T levels — and then check out the Lifehacks.
Aspirin, Colon Cancer Prevention, and Genetics
For some people with specific genetic variants, aspirin may help to prevent colon cancer. Learn more about what the research says and check your genes.
Prostate Health: How Genes, Diet, and Lifestyle Shape Your Risk
Do you know someone that suffers from prostate problems? Learn more about this important gland and how your genes affect your risk.
Parkinson’s Disease Risk: Genetics, Environmental Exposures, and Prevention Strategies
Parkinson’s: Explore key genes, environmental risks, gut microbiome factors, and research‑based lifehacks that may help protect dopaminergic neurons.
CYP2C9: Warfarin Dosing, NSAIDs, THC, and Drug Metabolism
Wonder why warfarin, ibuprofen, THC, or other drugs hit you harder than others? CYP2C9 genetic variants affect drug metabolism, side‑effect risk, and interactions with supplements and other medications.
CYP2C19: How Genetic Variants Affect SSRIs, Blood Thinners, and Toxins
CYP2C19 variants can affect how you respond to SSRIs, clopidogrel, diazepam, and PPIs. See what poor or ultra‑rapid metabolizer status may mean for side effects, treatment failure, and toxin metabolism.
Sulfotransferases: SULT Genes, Phase II Detoxification, and Sulfur
The SULT genes help with phase II detoxification of estrogens, neurotransmitters, certain carcinogens, and steroid hormones.
LDL Cholesterol: Genetics, Personalized Solutions
Your genes combine with your diet to influence your LDL cholesterol level. Learn more about why LDL cholesterol levels may matter in heart disease and find out how your genes are important here.
COMT: How to Optimize Your Supplements for Your COMT Genotype
Some supplements interact with COMT variants to impact the rate at which neurotransmitters are broken down. Check your COMT genotype and discover how this may affect your reaction to different supplements or combinations of supplements.
Are Cold Sores Genetic? Who Gets Them and Why
While many people carry the HSV virus, only about 30% will get cold sores. Genetics is one reason.
Fatigue: Root Causes, Genetics, Personalized Solutions
Are you always tired even when you know you slept well? Discover more about the newest research on fatigue and how genetic susceptibility plays a part for some people.
Estrogen, Histamine, and Mast Cell Connections
Mast cells can be more easily triggered in the presence of high estrogen or estrogen-mimicking compounds. Histamine can also trigger mast cell degranulation. Together, this can cause a lot of symptoms related to mast cell activation.
IL-13: Elevating Th2 Immune Response and Asthma risk
Interleukin-13 (IL-13) is a signaling molecule important in the immune response. Excessive IL-13 can tip you toward a Th2-dominant immune response, and variants increase the risk of allergies and asthma.
Spike Protein, Mast Cells, Histamine, and Heart Rhythms
Do you know of someone with unexplained heart palpitations, spiking blood pressure, dizziness, and tinnitus? Discover how research is linking these symptoms to histamine, mast cells, and the spike protein.
Alopecia Areata: Reasons for Rapid Hair Loss
Alopecia areata is an autoimmune-like disorder in which the immune system attacks the hair follicle. Learn about the triggers of alopecia areata, why the hair falls out, genetic variants that increase susceptibility, and possible treatment options.
Genetic Links to High Uric Acid and Gout
High uric acid levels can cause the pain and inflammation seen in gout. Find out how your genetic variants influence your uric acid levels and gout risk.
Glucuronidation: UGT Genetic Variants, Detoxification, and Hormone Balance
The UGT family of enzymes is responsible for an important part of phase II detoxification. This article explains what the UGT enzymes do in the body, how your genes impact this part of detoxification, and lifestyle factors that can increase or decrease this detox process.