Should you take folic acid?

There is a lot of buzz online about MTHFR variants and the need to avoid folic acid. I’ve seen recommendations ranging from avoiding all processed foods that are fortified with folic acid — to recommendations that people with MTHFR variants need to take extra…

Choline – An Essential Nutrient

I just finished listening to an interesting podcast featuring Dr. Zeisel, a researcher at the NC Nutrition Research Institute.  The interview discussed the body’s need for choline and the impact of some genetic variants on our ability to produce it in the body.  So…

Supplements for Methylation and More…

I have ended up a cabinet full of bottles of all kinds of supplements!  Every time I learn about something new — methylfolate for MTHFR polymorphisms, hydroxycobalamin for MTRR polymorphisms, vitamin A because I don’t convert beta carotene, etc – off I go to order…

MTR / MTRR – Homocysteine, methionine, and B12

MTR (methionine synthase) and MTRR (methionine synthase reductase) are two genes involved in the conversion of homocysteine to methionine, and a couple of fairly common gene variants cause the genes to work differently. Why is this something to care about? Methionine is an essential…

COMT – A gene that affects your neurotransmitter levels

COMT gene function: The COMT gene codes for the enzyme catechol-O-methyltransferase which breaks down (metabolizes) the neurotransmitters dopamine, epinephrine, and norepinephrine. This enzyme adds a methyl group from SAMe to the dopamine, epinephrine, or norepinephrine molecules, thus changing them into a different substance. COMT is also…

MTHFR Polymorphisms – Beyond 677

Going beyond MTHFR 677 and 1298 If you are just getting started with researching your MTHFR polymorphisms, you may want to start with some background information.  I have a list of resources on the MTHFR page that you might find helpful. MTHFR is a…