Choline – An Essential Nutrient

Choline is an essential nutrient that a lot of us don’t get enough of. In fact, the majority of the US population doesn’t get enough choline on a daily basis. Insufficient choline can impact mental sharpness, heart health, fatty liver disease, and more. [ref]…

COMT – A gene that affects your neurotransmitter levels

Having trouble with supplements containing methyl groups? Wondering why your neurotransmitters are out of balance? It could be due to your COMT genetic variants. This important enzyme is tasked with breaking down neurotransmitters, such as dopamine. What does the COMT gene do? The COMT gene…

Should you take folic acid?

There is a lot of buzz online about MTHFR variants and the need to avoid folic acid. I’ve seen recommendations ranging from avoiding all processed foods that are fortified with folic acid — to recommendations that people with MTHFR variants need to take extra…

Supplements for Methylation and More…

I have ended up a cabinet full of bottles of all kinds of supplements!  Every time I learn about something new — methylfolate for MTHFR polymorphisms, hydroxycobalamin for MTRR polymorphisms, vitamin A because I don’t convert beta carotene, etc – off I go to order…

MTR / MTRR – Homocysteine, methionine, and B12

MTR (methionine synthase) and MTRR (methionine synthase reductase) are two genes that code for enzymes that are involved in the conversion of homocysteine to methionine. They are both important in the methylation cycle. MTR, MTRR – Methionine and B12: Methionine is an essential amino…

MTHFR Polymorphisms – Beyond 677

Going beyond MTHFR 677 and 1298 If you are just getting started with researching your MTHFR polymorphisms, you may want to start with some background information.  I have a list of resources on the MTHFR page that you might find helpful. MTHFR is a…