Which Type of Choline Works Best with Your Genes?
Which choline supplement works best based on your PEMT, MTHFD1, and CHKA genes? Compare citicoline, alpha-GPC, PC, and betaine.
methylation
ME/CFS and Genetics: Chronic Fatigue Syndrome Genes, Immune Pathways, and Natural Solutions
Genetic variants in immune, mitochondrial, and inflammatory pathways (NK cells, NLRP3, interferon, complement, TRP channels) increase ME/CFS susceptibility. Check your genes and explore research-backed solutions.
Histamine Intolerance Genetics: DAO & HNMT Genes, Supplements
Genetic variants in DAO and HNMT genes affect histamine breakdown. Check your AOC1, HNMT, and HDC genotype. Low-histamine diet, DAO supplements, and more.
Nicotinamide Riboside and NMN: Boosting NAD+ in Aging with Supplements
Explore the research about how nicotinamide riboside (NR) and NMN are being used to reverse aging. Learn about how your genes naturally affect your NAD+ levels and how this interacts with the aging process.
MTHFR Gene Explained: C677T and A1298C Variants, Testing, and Solutions
The MTHFR gene is important for how your body utilizes folate (vitamin B9) for creating neurotransmitters, detoxifying toxicants, and maintaining a healthy heart. It is a key gene in the methylation cycle.
FOLR1 and FOLR2: Transporting Folate, Folinic Acid, and Folic Acid into Cells
Genetic variants in the FOLR1 and FOLR2 genes (folate receptors alpha and beta) can impact folate in the brain and in the immune response.
DHFR and MTHFR: Folic Acid Metabolism
Methylfolate and folic acid—what’s the difference? Learn how DHFR and MTHFR variants affect folic acid metabolism, unmetabolized folic acid, cancer and autism risk, BH4 recycling, and how to choose the right supplement for your genes.
FTO and m6A Methylation
Recently, researchers discovered that FTO is an m6A eraser that removes methyl groups from mRNA. This discovery has opened up huge avenues of research on topics from cancer to immune response to heart disease.
Migraine Solutions Tailored to Your Genes: Triggers, Treatments, and Tools
Discover how genetics, triggers, and personalized strategies shape migraine prevention and relief. Find actionable solutions based on your DNA.
Vitamin B12, MTR & MTRR, and Methylation
There are several genes that can influence your absorption, transport, and need for vitamin B12. Some people need higher amounts of B12, and some people thrive on different forms of B12. Take a look at your genetic data to see if you should up your intake of B12.
Vitamin B6: Genetics, Absorption, and Deficiency
Vitamin B6 is an important co-factor in hundreds of different enzymatic reactions. Low levels of B6 are linked to an increased risk of diabetes, cardiovascular disease, neurodegenerative diseases, and cancer. B6 is also essential for reducing oxidative stress and inflammation.
Creatine: Boosting Muscles and Increasing Brain Power
Creatine is an amino acid used in muscle tissue and the brain for energy in times of stress. Genes play a role in creatine synthesis. Find out what the research shows about creatine supplements for muscle mass and cognitive function.
Multiple Chemical Sensitivity (MCS): Genetics, Causes, and Solutions
Struggling with Multiple Chemical Sensitivity (MCS)? Learn about the connection between genetics, detoxification enzymes, and the olfactory system.
Riboflavin (Vitamin B2), MTHFR, and Deficiency Symptoms
Learn how riboflavin (vitamin B2) affects MTHFR genes, methylation, and energy. Find out the deficiency symptoms, food sources, dosage, and whether you need more based on your genetics.
Folate Optimization: MTHFR and Fertility
MTHFR variants affect the conversion of folate into the active form. Learn how this can affect you if you are trying to get pregnant.
Blood Pressure, MTHFR, and Riboflavin
The common MTHFR C677T variant increases the relative risk of high blood pressure. Learn how to add more Riboflavin (B2) into your diet to reduce risk.
Estrogen, Histamine, and Mast Cell Connections
Mast cells can be more easily triggered in the presence of high estrogen or estrogen-mimicking compounds. Histamine can also trigger mast cell degranulation. Together, this can cause a lot of symptoms related to mast cell activation.
Arsenic Detoxification and Your Genes
Arsenic exposure occurs via well water, in certain foods, and through breathing. This article covers the pathways the body uses to get rid of arsenic, and it includes information on genetic variants that may impair the detoxification of arsenic.
Underlying Cause(s) of Depression: Leveraging Your Genetic Data
Depression can have multiple physiological causes. This article ties together 9 separate articles on depression to simply your genetic search.
CBS Gene Variants and Low Sulfur Diet
Some clinicians recommend a low sulfur diet for people with CBS mutations. Find out what the research shows – and why that recommendation is not backed up. (Member’s article)
MTHFR: Going Beyond C677T and A1298C
The MTHFR C677T and A1298C variants get a lot of press, but they do not give the whole picture of the MTHFR gene. Additional variants are impacting the functionality of the enzyme.
MTHFR, Depression, Anxiety, Symptoms and Treatment
We are all genetically unique, and a common genetic variant in the MTHFR gene causes some people to be more susceptible to having low folate levels. This article explains the research linking MTHFR variants, folate, and depression — and gives you information on how diet or supplements may help.
Vaccines and the MTHFR mutation
This article covers what the research shows about folate metabolism, MTHFR, and immune response. See what the research says.
BHMT: Genetic Variants that Impact Methylation
BHMT is involved in homocysteine methylation and impacts the methylation cycle.
MTHFR and Migraines
The MTHFR C677T variant increases the risk of migraines. Learn how to check your genetic data and how to mitigate the risk.